NZ598121A - Nitroimidazooxazines and their uses in anti-tubercular therapy - Google Patents
Nitroimidazooxazines and their uses in anti-tubercular therapyInfo
- Publication number
- NZ598121A NZ598121A NZ598121A NZ59812110A NZ598121A NZ 598121 A NZ598121 A NZ 598121A NZ 598121 A NZ598121 A NZ 598121A NZ 59812110 A NZ59812110 A NZ 59812110A NZ 598121 A NZ598121 A NZ 598121A
- Authority
- NZ
- New Zealand
- Prior art keywords
- nitroimidazooxazines
- oxazine
- imidazo
- trifluoromethoxy
- dihydro
- Prior art date
Links
- YVMGQODAKAHLHB-UHFFFAOYSA-N 3-nitroimidazo[4,5-e]oxazine Chemical class O1N=C([N+](=O)[O-])C=C2N=CN=C21 YVMGQODAKAHLHB-UHFFFAOYSA-N 0.000 title 1
- 230000002365 anti-tubercular Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- PBMCMZFEDXCLOG-SFHVURJKSA-N (6s)-2-nitro-6-[[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]methoxy]-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine Chemical compound O([C@H]1CN2C=C(N=C2OC1)[N+](=O)[O-])CC(C=C1)=CC=C1CC1=CC=C(OC(F)(F)F)C=C1 PBMCMZFEDXCLOG-SFHVURJKSA-N 0.000 abstract 1
- JRMJATJTHVCYRK-SFHVURJKSA-N (6s)-2-nitro-6-[[6-[2-[4-(trifluoromethoxy)phenyl]ethynyl]pyridin-3-yl]methoxy]-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine Chemical compound O([C@H]1CN2C=C(N=C2OC1)[N+](=O)[O-])CC(C=N1)=CC=C1C#CC1=CC=C(OC(F)(F)F)C=C1 JRMJATJTHVCYRK-SFHVURJKSA-N 0.000 abstract 1
- AFVACAZNAUREGB-HNNXBMFYSA-N (6s)-6-[[4-[2-chloro-4-(trifluoromethoxy)phenyl]phenyl]methoxy]-2-nitro-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine Chemical compound O([C@H]1CN2C=C(N=C2OC1)[N+](=O)[O-])CC(C=C1)=CC=C1C1=CC=C(OC(F)(F)F)C=C1Cl AFVACAZNAUREGB-HNNXBMFYSA-N 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23039609P | 2009-07-31 | 2009-07-31 | |
| PCT/US2010/043906 WO2011014774A1 (en) | 2009-07-31 | 2010-07-30 | Nitroimidazooxazines and their uses in anti-tubercular therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ598121A true NZ598121A (en) | 2013-04-26 |
Family
ID=42937154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ598121A NZ598121A (en) | 2009-07-31 | 2010-07-30 | Nitroimidazooxazines and their uses in anti-tubercular therapy |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2459571B1 (enExample) |
| JP (1) | JP5781072B2 (enExample) |
| KR (1) | KR101746482B1 (enExample) |
| CN (1) | CN102753558B (enExample) |
| AU (1) | AU2010278777B2 (enExample) |
| BR (1) | BR112012002278A2 (enExample) |
| CA (1) | CA2769359C (enExample) |
| ES (1) | ES2536997T3 (enExample) |
| IN (1) | IN2012DN01414A (enExample) |
| NZ (1) | NZ598121A (enExample) |
| RU (1) | RU2542988C2 (enExample) |
| WO (1) | WO2011014774A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9051333B2 (en) | 2011-04-15 | 2015-06-09 | Otsuka Pharmaceutical Co., Ltd. | 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides |
| CN104059082B (zh) * | 2013-03-21 | 2016-08-03 | 苏州迈泰生物技术有限公司 | 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用 |
| KR101682356B1 (ko) | 2014-11-04 | 2016-12-06 | 한국화학연구원 | 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| BR112017015744A2 (pt) | 2015-01-29 | 2018-03-13 | Medshine Discovery Inc | composto apresentando uma estrutura de fórmula (i), um sal farmaceuticamente aceitável do mesmo ou um isômero ótico do mesmo, composição farmacêutica e uso do composto de fórmula (i) para o tratamento e prevenção de mycobacterium tuberculosis ou outras infecções microbianas |
| CN108047248A (zh) * | 2018-02-12 | 2018-05-18 | 丹诺医药(苏州）有限公司 | 噁唑烷酮-硝基咪唑类偶联分子的应用 |
| CN113527331B (zh) * | 2020-04-17 | 2024-05-28 | 南京长澳医药科技有限公司 | 硝基咪唑类衍生物及其制备方法和用途 |
| CN113355439A (zh) * | 2021-06-07 | 2021-09-07 | 深圳市普瑞康生物技术有限公司 | 一种结核分枝杆菌潜伏感染及发病的新型组合检测方法 |
| CN114469946B (zh) * | 2022-02-24 | 2023-10-24 | 首都医科大学附属北京胸科医院 | 德拉马尼作为cxcl10抑制剂的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU679626B2 (en) | 1994-03-08 | 1997-07-03 | Wyeth | Thiazolidinedione derivatives as anti-hyperglycemic agents |
| US6087358A (en) * | 1995-06-26 | 2000-07-11 | Pathogenesis Corporation | Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof |
| US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| TWI347946B (en) * | 2002-10-11 | 2011-09-01 | Otsuka Pharma Co Ltd | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound |
| ZA200602184B (en) * | 2003-10-31 | 2007-10-31 | Otsuka Pharma Co Ltd | 2,3-dihydro-6-nitroimidazo (2,1-B) oxazole compounds for the treatment of tuberculosis |
| ATE382609T1 (de) | 2004-01-16 | 2008-01-15 | Sumitomo Chemical Co | Malononitrilverbindungen als pestizide |
| TWI300409B (en) * | 2004-02-18 | 2008-09-01 | Otsuka Pharma Co Ltd | Method for producing 4-nitroimidazole compound |
| WO2006043121A1 (en) * | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| JP2009502922A (ja) * | 2005-07-28 | 2009-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ阻害剤プロドラッグ |
| AU2006331676A1 (en) | 2005-12-23 | 2007-07-05 | Novartis Ag | Nitroimidazole compounds |
| EP2254892B1 (en) * | 2008-03-26 | 2014-04-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
-
2010
- 2010-07-30 AU AU2010278777A patent/AU2010278777B2/en not_active Ceased
- 2010-07-30 ES ES10742955.7T patent/ES2536997T3/es active Active
- 2010-07-30 EP EP10742955.7A patent/EP2459571B1/en not_active Not-in-force
- 2010-07-30 RU RU2012107176/04A patent/RU2542988C2/ru not_active IP Right Cessation
- 2010-07-30 JP JP2012523087A patent/JP5781072B2/ja not_active Expired - Fee Related
- 2010-07-30 WO PCT/US2010/043906 patent/WO2011014774A1/en not_active Ceased
- 2010-07-30 IN IN1414DEN2012 patent/IN2012DN01414A/en unknown
- 2010-07-30 NZ NZ598121A patent/NZ598121A/xx not_active IP Right Cessation
- 2010-07-30 CA CA2769359A patent/CA2769359C/en not_active Expired - Fee Related
- 2010-07-30 BR BR112012002278-4A patent/BR112012002278A2/pt not_active IP Right Cessation
- 2010-07-30 KR KR1020127005320A patent/KR101746482B1/ko not_active Expired - Fee Related
- 2010-07-30 CN CN201080041453.9A patent/CN102753558B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2536997T3 (es) | 2015-06-01 |
| AU2010278777B2 (en) | 2015-05-07 |
| JP5781072B2 (ja) | 2015-09-16 |
| BR112012002278A2 (pt) | 2020-09-15 |
| WO2011014774A1 (en) | 2011-02-03 |
| KR101746482B1 (ko) | 2017-06-27 |
| RU2542988C2 (ru) | 2015-02-27 |
| EP2459571B1 (en) | 2015-03-11 |
| IN2012DN01414A (enExample) | 2015-06-05 |
| CA2769359C (en) | 2017-03-07 |
| EP2459571A1 (en) | 2012-06-06 |
| CN102753558A (zh) | 2012-10-24 |
| CA2769359A1 (en) | 2011-02-03 |
| JP2013500996A (ja) | 2013-01-10 |
| RU2012107176A (ru) | 2013-09-10 |
| AU2010278777A1 (en) | 2012-03-01 |
| CN102753558B (zh) | 2014-10-15 |
| KR20120084713A (ko) | 2012-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 30 JUL 2017 BY CPA GLOBAL Effective date: 20140626 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 30 JUL 2018 BY CPA GLOBAL Effective date: 20170622 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 30 JUL 2019 BY CPA GLOBAL Effective date: 20180705 |
|
| LAPS | Patent lapsed |