NZ589571A - Method for treating cognitive deficits using trans-4-((1r,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine - Google Patents
Method for treating cognitive deficits using trans-4-((1r,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazineInfo
- Publication number
- NZ589571A NZ589571A NZ589571A NZ58957109A NZ589571A NZ 589571 A NZ589571 A NZ 589571A NZ 589571 A NZ589571 A NZ 589571A NZ 58957109 A NZ58957109 A NZ 58957109A NZ 589571 A NZ589571 A NZ 589571A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- cognitive
- eur
- trimethylpiperazine
- chloro
- Prior art date
Links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
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| US20110178094A1 (en) * | 2008-10-03 | 2011-07-21 | H. Lundbeck A/S | Oral Formulation |
| JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
| PE20150928A1 (es) | 2011-06-20 | 2015-06-26 | Lundbeck & Co As H | 1-piperazino-3-fenil-indanos deuterados para el tratamiento de esquizofrenia |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| US20210395208A1 (en) * | 2018-10-29 | 2021-12-23 | H. Lundeck A/S | Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts |
| WO2020114853A1 (en) | 2018-12-03 | 2020-06-11 | H. Lundbeck A/S | Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4031216A (en) * | 1974-08-12 | 1977-06-21 | Knoll A.G. Chemische Fabriken | 3-(3,4-Dialkoxy-benzyl)-3-methyl-piperazines |
| NZ196284A (en) * | 1980-02-29 | 1983-12-16 | Kefalas As | 1-piperazino-3-phenylindane derivatives:pharmaceutical compositions |
| DE3139970A1 (de) * | 1981-10-08 | 1983-04-28 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5026853A (en) * | 1987-04-01 | 1991-06-25 | Janssen Pharmaceutica N.V. | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide |
| US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
| DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
| CA2132411A1 (en) * | 1994-09-19 | 1996-03-20 | Michael Trani | Enzymatic esterification of long-chain racemic acids and alcohols |
| US6410794B1 (en) * | 1994-12-16 | 2002-06-25 | Uop Llc | Process for preparation of pharmaceutically desired chiral tetralone from tetralones |
| US6455736B1 (en) * | 1994-12-16 | 2002-09-24 | Uop Llc | Process for preparation of pharmaceutically desired sertraline and sertraline analogs |
| US5807897A (en) * | 1996-03-01 | 1998-09-15 | Zeneca Limited | Aminotetralin derivative and compositions and method of use thereof |
| PT1073618E (pt) * | 1998-05-01 | 2004-03-31 | Pfizer Prod Inc | Processo para a producao de sertralina-tetralona enantiomericamente pura ou opticamente enriquecida usando cromotografia continua |
| DE19824470A1 (de) * | 1998-05-30 | 1999-12-02 | Boehringer Ingelheim Pharma | Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| IN187170B (enExample) * | 2000-01-04 | 2002-02-23 | Sun Pharmaceutical Ind Ltd | |
| IL162458A0 (en) * | 2001-12-28 | 2005-11-20 | Teva Pharma | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
| WO2004039322A2 (en) * | 2002-10-29 | 2004-05-13 | Miicro, Inc. | Novel combination therapy for schizophrenia focused on improved cognition: 5-ht-2a/d2 blockade with adjunctive blockade of prefrontal da reuptake |
| EP1658276B1 (en) * | 2003-08-18 | 2012-10-10 | H. Lundbeck A/S | Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
| TW200640891A (en) * | 2005-02-16 | 2006-12-01 | Lundbeck & Co As H | Tartrate and malate salts of a pharmarceutical compound |
| MX2007009816A (es) * | 2005-02-16 | 2007-09-07 | Lundbeck & Co As H | Sales de tartrato y de malato de trans-1-((1r,3s)-6-cloro-3- fenilindan-1-i1)-3,3-dimetilpiperazina. |
| TWI376373B (en) * | 2005-02-16 | 2012-11-11 | Lundbeck & Co As H | Crystalline base of a pharmaceutical compound |
| TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| US20110178094A1 (en) * | 2008-10-03 | 2011-07-21 | H. Lundbeck A/S | Oral Formulation |
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- 2009-05-07 NZ NZ589571A patent/NZ589571A/en not_active IP Right Cessation
- 2009-05-07 CA CA2722374A patent/CA2722374A1/en not_active Abandoned
- 2009-05-07 KR KR1020107024956A patent/KR20110021754A/ko not_active Withdrawn
- 2009-05-07 CN CN2009801162104A patent/CN102065861B/zh not_active Expired - Fee Related
- 2009-05-07 WO PCT/DK2009/050107 patent/WO2009135495A1/en not_active Ceased
- 2009-05-07 EA EA201071273A patent/EA018927B1/ru not_active IP Right Cessation
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- 2009-05-07 EP EP09741768A patent/EP2285377A1/en not_active Withdrawn
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2011
- 2011-05-05 US US13/101,176 patent/US20110207744A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011519873A (ja) | 2011-07-14 |
| MX2010012037A (es) | 2010-11-30 |
| ZA201007912B (en) | 2012-02-29 |
| EP2285377A1 (en) | 2011-02-23 |
| IL209084A0 (en) | 2011-01-31 |
| EA018927B1 (ru) | 2013-11-29 |
| CN102065861A (zh) | 2011-05-18 |
| AU2009243813B2 (en) | 2014-05-29 |
| KR20110021754A (ko) | 2011-03-04 |
| US20090306092A1 (en) | 2009-12-10 |
| CA2722374A1 (en) | 2009-11-12 |
| CO6311083A2 (es) | 2011-08-22 |
| US20110207744A1 (en) | 2011-08-25 |
| AU2009243813A1 (en) | 2009-11-12 |
| BRPI0912223A2 (pt) | 2015-10-06 |
| CN102065861B (zh) | 2013-10-16 |
| EA201071273A1 (ru) | 2011-06-30 |
| WO2009135495A1 (en) | 2009-11-12 |
| HK1157674A1 (en) | 2012-07-06 |
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