EA018927B1 - Способ лечения когнитивного расстройства, ассоциированного с шизофренией - Google Patents
Способ лечения когнитивного расстройства, ассоциированного с шизофренией Download PDFInfo
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- EA018927B1 EA018927B1 EA201071273A EA201071273A EA018927B1 EA 018927 B1 EA018927 B1 EA 018927B1 EA 201071273 A EA201071273 A EA 201071273A EA 201071273 A EA201071273 A EA 201071273A EA 018927 B1 EA018927 B1 EA 018927B1
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- compound
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- schizophrenia
- phenylindan
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Neurosurgery (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Psychology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| DKPA200801519 | 2008-11-04 | ||
| PCT/DK2009/050107 WO2009135495A1 (en) | 2008-05-07 | 2009-05-07 | Method for treating cognitive deficits |
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| EA201071273A1 EA201071273A1 (ru) | 2011-06-30 |
| EA018927B1 true EA018927B1 (ru) | 2013-11-29 |
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| ZA (1) | ZA201007912B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110178094A1 (en) * | 2008-10-03 | 2011-07-21 | H. Lundbeck A/S | Oral Formulation |
| ME02513B (me) | 2011-06-20 | 2017-02-20 | H Lundbeck As | Deuterizovani 1-piperazino-3-fenil indani za tretiranje šizofrenije |
| JO3421B1 (ar) * | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| JP7442538B2 (ja) * | 2018-10-29 | 2024-03-04 | ハー・ルンドベック・アクチエゼルスカベット | 非晶性の式（ｉ）の化合物及び非晶性の式（ｉ）の化合物塩 |
| JP7583719B2 (ja) | 2018-12-03 | 2024-11-14 | ハー・ルンドベック・アクチエゼルスカベット | ４－（（１Ｒ，３Ｓ）－６－クロロ－３－フェニル－２，３－ジヒドロ－１Ｈ－インデン－１－イル）－１，２，２－トリメチルピペラジン及び４－（（１Ｒ，３Ｓ）－６－クロロ－３－（フェニル－ｄ５）－２，３－ジヒドロ－１Ｈ－インデン－１－イル）－２，２－ジメチル－１－（メチル－ｄ３）ピペラジンのプロドラッグ |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993022293A1 (en) * | 1992-04-28 | 1993-11-11 | H. Lundbeck A/S | 1-piperazino-1,2-dihydroindene derivatives |
| WO2005016900A1 (en) * | 2003-08-18 | 2005-02-24 | H. Lundbeck A/S | Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament |
| WO2006086985A1 (en) * | 2005-02-16 | 2006-08-24 | H. Lundbeck A/S | Tartrate and malate salts of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
| WO2006086986A1 (en) * | 2005-02-16 | 2006-08-24 | H. Lundbeck A/S | Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031216A (en) * | 1974-08-12 | 1977-06-21 | Knoll A.G. Chemische Fabriken | 3-(3,4-Dialkoxy-benzyl)-3-methyl-piperazines |
| NZ196284A (en) * | 1980-02-29 | 1983-12-16 | Kefalas As | 1-piperazino-3-phenylindane derivatives:pharmaceutical compositions |
| DE3139970A1 (de) * | 1981-10-08 | 1983-04-28 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5026853A (en) * | 1987-04-01 | 1991-06-25 | Janssen Pharmaceutica N.V. | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide |
| US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
| CA2132411A1 (en) * | 1994-09-19 | 1996-03-20 | Michael Trani | Enzymatic esterification of long-chain racemic acids and alcohols |
| US6455736B1 (en) * | 1994-12-16 | 2002-09-24 | Uop Llc | Process for preparation of pharmaceutically desired sertraline and sertraline analogs |
| US6410794B1 (en) * | 1994-12-16 | 2002-06-25 | Uop Llc | Process for preparation of pharmaceutically desired chiral tetralone from tetralones |
| US5807897A (en) * | 1996-03-01 | 1998-09-15 | Zeneca Limited | Aminotetralin derivative and compositions and method of use thereof |
| WO1999057089A1 (en) * | 1998-05-01 | 1999-11-11 | Pfizer Products Inc. | Process for the production of enantiomerically pure or optically enriched sertraline-tetralone using continuous chromatography |
| DE19824470A1 (de) * | 1998-05-30 | 1999-12-02 | Boehringer Ingelheim Pharma | Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| IN187170B (enExample) * | 2000-01-04 | 2002-02-23 | Sun Pharmaceutical Ind Ltd | |
| EP1465601A4 (en) * | 2001-12-28 | 2006-02-15 | Teva Pharma | STABLE PHARMACEUTICAL FORMULATION OF PAROXETINE ANHYDROUS HYDROCHLORIDE AND PREPARATION METHOD |
| WO2004039322A2 (en) * | 2002-10-29 | 2004-05-13 | Miicro, Inc. | Novel combination therapy for schizophrenia focused on improved cognition: 5-ht-2a/d2 blockade with adjunctive blockade of prefrontal da reuptake |
| TW200640891A (en) * | 2005-02-16 | 2006-12-01 | Lundbeck & Co As H | Tartrate and malate salts of a pharmarceutical compound |
| TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| US20110178094A1 (en) * | 2008-10-03 | 2011-07-21 | H. Lundbeck A/S | Oral Formulation |
-
2009
- 2009-05-07 EA EA201071273A patent/EA018927B1/ru not_active IP Right Cessation
- 2009-05-07 KR KR1020107024956A patent/KR20110021754A/ko not_active Withdrawn
- 2009-05-07 JP JP2011507792A patent/JP2011519873A/ja active Pending
- 2009-05-07 WO PCT/DK2009/050107 patent/WO2009135495A1/en not_active Ceased
- 2009-05-07 EP EP09741768A patent/EP2285377A1/en not_active Withdrawn
- 2009-05-07 BR BRPI0912223A patent/BRPI0912223A2/pt not_active IP Right Cessation
- 2009-05-07 AU AU2009243813A patent/AU2009243813B2/en not_active Ceased
- 2009-05-07 US US12/437,363 patent/US20090306092A1/en not_active Abandoned
- 2009-05-07 MX MX2010012037A patent/MX2010012037A/es not_active Application Discontinuation
- 2009-05-07 NZ NZ589571A patent/NZ589571A/en not_active IP Right Cessation
- 2009-05-07 CA CA2722374A patent/CA2722374A1/en not_active Abandoned
- 2009-05-07 CN CN2009801162104A patent/CN102065861B/zh not_active Expired - Fee Related
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2010
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2011
- 2011-05-05 US US13/101,176 patent/US20110207744A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993022293A1 (en) * | 1992-04-28 | 1993-11-11 | H. Lundbeck A/S | 1-piperazino-1,2-dihydroindene derivatives |
| WO2005016900A1 (en) * | 2003-08-18 | 2005-02-24 | H. Lundbeck A/S | Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament |
| WO2006086985A1 (en) * | 2005-02-16 | 2006-08-24 | H. Lundbeck A/S | Tartrate and malate salts of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
| WO2006086986A1 (en) * | 2005-02-16 | 2006-08-24 | H. Lundbeck A/S | Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
Non-Patent Citations (1)
| Title |
|---|
| BOGESO K.P. ET AL.: "ENHANCED D1 AFFINITY IN A SERIES OF PIPERAZINE RING SUBSTITUTED 1-PIPERAZINO-3-ARYLINDANS WITH POTENTIAL ATYPICAL ANTIPSYCHOTIC ACTIVITY" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 38, no. 22, 1 January 1995 (1995-01-01), pages 4380-4392, XP008037648 ISSN: 0022-2623 abstract; table 5; compound 38 * |
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| US20110207744A1 (en) | 2011-08-25 |
| AU2009243813B2 (en) | 2014-05-29 |
| EP2285377A1 (en) | 2011-02-23 |
| HK1157674A1 (en) | 2012-07-06 |
| ZA201007912B (en) | 2012-02-29 |
| JP2011519873A (ja) | 2011-07-14 |
| KR20110021754A (ko) | 2011-03-04 |
| NZ589571A (en) | 2012-07-27 |
| US20090306092A1 (en) | 2009-12-10 |
| WO2009135495A1 (en) | 2009-11-12 |
| MX2010012037A (es) | 2010-11-30 |
| EA201071273A1 (ru) | 2011-06-30 |
| CN102065861A (zh) | 2011-05-18 |
| CN102065861B (zh) | 2013-10-16 |
| AU2009243813A1 (en) | 2009-11-12 |
| BRPI0912223A2 (pt) | 2015-10-06 |
| IL209084A0 (en) | 2011-01-31 |
| CO6311083A2 (es) | 2011-08-22 |
| CA2722374A1 (en) | 2009-11-12 |
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