NZ571201A - DNA Conformation (loop structures) in normal and abnormal gene expression - Google Patents
DNA Conformation (loop structures) in normal and abnormal gene expressionInfo
- Publication number
- NZ571201A NZ571201A NZ571201A NZ57120107A NZ571201A NZ 571201 A NZ571201 A NZ 571201A NZ 571201 A NZ571201 A NZ 571201A NZ 57120107 A NZ57120107 A NZ 57120107A NZ 571201 A NZ571201 A NZ 571201A
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0603251D0 (en) | 2006-02-17 | 2006-03-29 | Isis Innovation | DNA conformation |
| JP5346957B2 (ja) | 2008-01-23 | 2013-11-20 | ヘルレフ ホスピタル | 不特定疾患の汎用マーカーとしてのｙｋｌ−４０ |
| GB0810051D0 (en) * | 2008-06-02 | 2008-07-09 | Oxford Biodynamics Ltd | Method of diagnosis |
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| WO2012005595A2 (en) * | 2010-07-09 | 2012-01-12 | Wouter Leonard De Laat | V3-d genomic region of interest sequencing strategies |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
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| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| AU2013302756C1 (en) | 2012-08-14 | 2018-05-17 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9411930B2 (en) | 2013-02-01 | 2016-08-09 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
| KR20200140929A (ko) | 2013-02-08 | 2020-12-16 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
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| BR112016023625A2 (pt) | 2014-04-10 | 2018-06-26 | 10X Genomics, Inc. | dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos |
| CA2953469A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| WO2015200893A2 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| US10526641B2 (en) | 2014-08-01 | 2020-01-07 | Dovetail Genomics, Llc | Tagging nucleic acids for sequence assembly |
| BR112017008877A2 (pt) | 2014-10-29 | 2018-07-03 | 10X Genomics Inc | métodos e composições para sequenciamento de ácido nucleico-alvo |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
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| WO2016134034A1 (en) | 2015-02-17 | 2016-08-25 | Dovetail Genomics Llc | Nucleic acid sequence assembly |
| EP3262407B1 (en) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Partition processing methods and systems |
| MX2017010857A (es) | 2015-02-24 | 2017-12-11 | 10X Genomics Inc | Metodos para la cobertura de secuencia de acidos nucleicos seleccionados como diana. |
| US11807896B2 (en) | 2015-03-26 | 2023-11-07 | Dovetail Genomics, Llc | Physical linkage preservation in DNA storage |
| JP2018527016A (ja) | 2015-06-24 | 2018-09-20 | オックスフォード バイオダイナミックス リミテッド | 染色体相互作用の検出 |
| CA3002740A1 (en) | 2015-10-19 | 2017-04-27 | Dovetail Genomics, Llc | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
| JP6954899B2 (ja) | 2015-12-04 | 2021-10-27 | １０エックス ゲノミクス，インコーポレイテッド | 核酸の解析のための方法及び組成物 |
| SG11201807117WA (en) | 2016-02-23 | 2018-09-27 | Dovetail Genomics Llc | Generation of phased read-sets for genome assembly and haplotype phasing |
| GB201608000D0 (en) | 2016-05-06 | 2016-06-22 | Oxford Biodynamics Ltd | Chromosome detection |
| WO2017197343A2 (en) | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
| KR102412442B1 (ko) | 2016-05-13 | 2022-06-22 | 더브테일 제노믹스 엘엘씨 | 보존된 샘플로부터의 장범위 링키지 정보의 회수 |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| EP3548633B1 (en) * | 2016-12-01 | 2024-01-24 | Oxford BioDynamics PLC | Application of epigenetic chromsomal interactions in cancer diagnostics |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2018115802A1 (en) * | 2016-12-23 | 2018-06-28 | Oxford Biodynamics Limited | Typing method |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| EP4029939B1 (en) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| EP3445876B1 (en) | 2017-05-26 | 2023-07-05 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| US10400235B2 (en) | 2017-05-26 | 2019-09-03 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| CA3078675A1 (en) | 2017-11-03 | 2019-05-09 | Oxford Biodynamics Limited | Genetic regulation |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| EP3746566A1 (en) | 2018-01-31 | 2020-12-09 | Dovetail Genomics, LLC | Sample prep for dna linkage recovery |
| US12377396B2 (en) | 2018-02-05 | 2025-08-05 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for multiplexed measurements in single and ensemble cells |
| CN112262218B (zh) | 2018-04-06 | 2024-11-08 | 10X基因组学有限公司 | 用于单细胞处理中的质量控制的系统和方法 |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| US20220403371A1 (en) * | 2019-11-15 | 2022-12-22 | Phase Genomics, Inc. | Chromosome conformation capture from tissue samples |
| CN114550817B (zh) * | 2022-01-25 | 2022-12-23 | 云南大学 | 基于多特征的ctcf介导染色质环预测方法 |
| CN114841294B (zh) * | 2022-07-04 | 2022-10-28 | 杭州德适生物科技有限公司 | 一种检测染色体结构异常的分类器模型训练方法及装置 |
Family Cites Families (7)
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| AU2002220521A1 (en) | 2000-11-29 | 2002-06-11 | Statens Seruminstitut | A screening assay for detecting chromosome rearrangements or recombinations |
| CN1231596C (zh) * | 2001-12-27 | 2005-12-14 | 赵兴波 | 利用线粒体dna指纹进行动物遗传信息鉴定的方法 |
| CN1515692A (zh) * | 2003-01-02 | 2004-07-28 | 缪金明 | “锚定点灯”式寡核苷酸芯片的检测技术 |
| CA2554818A1 (en) | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features |
| US20060015264A1 (en) | 2004-06-02 | 2006-01-19 | Mcshea Andrew | Interfering stem-loop sequences and method for identifying |
| AU2006264564B2 (en) * | 2005-07-04 | 2012-04-19 | Erasmus University Medical Center | Chromosome conformation capture-on-chip (4c) assay |
| GB0603251D0 (en) | 2006-02-17 | 2006-03-29 | Isis Innovation | DNA conformation |
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| GB0603251D0 (en) | 2006-03-29 |
| DK1991697T3 (da) | 2011-09-19 |
| US20090186352A1 (en) | 2009-07-23 |
| CA2642331A1 (en) | 2007-08-23 |
| JP5345857B2 (ja) | 2013-11-20 |
| CN101384734B (zh) | 2013-10-30 |
| US20180080081A1 (en) | 2018-03-22 |
| HK1125416A1 (en) | 2009-08-07 |
| CN101384734A (zh) | 2009-03-11 |
| NO20083957L (no) | 2008-11-14 |
| EP1991697B1 (en) | 2011-08-10 |
| AU2007216315B2 (en) | 2012-10-04 |
| CA2642331C (en) | 2018-06-19 |
| ATE519864T1 (de) | 2011-08-15 |
| US11384396B2 (en) | 2022-07-12 |
| WO2007093819A2 (en) | 2007-08-23 |
| ES2368767T3 (es) | 2011-11-22 |
| JP2009526543A (ja) | 2009-07-23 |
| ZA200807948B (en) | 2009-11-25 |
| EP1991697A2 (en) | 2008-11-19 |
| AU2007216315A1 (en) | 2007-08-23 |
| US9777327B2 (en) | 2017-10-03 |
| NO343718B1 (no) | 2019-05-20 |
| MY182608A (en) | 2021-01-26 |
| WO2007093819A3 (en) | 2007-10-04 |
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