NZ549254A - Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors - Google Patents
Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitorsInfo
- Publication number
- NZ549254A NZ549254A NZ549254A NZ54925405A NZ549254A NZ 549254 A NZ549254 A NZ 549254A NZ 549254 A NZ549254 A NZ 549254A NZ 54925405 A NZ54925405 A NZ 54925405A NZ 549254 A NZ549254 A NZ 549254A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hexahydro
- 10brs
- hydroxy
- 4ars
- phenanthridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/16—Otologicals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100990 | 2004-03-10 | ||
| EP04106677 | 2004-12-17 | ||
| PCT/EP2005/051054 WO2005087745A1 (en) | 2004-03-10 | 2005-03-09 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ549254A true NZ549254A (en) | 2010-06-25 |
Family
ID=34965034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ549254A NZ549254A (en) | 2004-03-10 | 2005-03-09 | Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070185149A1 (es) |
| EP (1) | EP1725534A1 (es) |
| JP (1) | JP2007527901A (es) |
| KR (1) | KR20060130697A (es) |
| CN (1) | CN1926113B (es) |
| AR (1) | AR049324A1 (es) |
| AU (1) | AU2005221832A1 (es) |
| BR (1) | BRPI0508481A (es) |
| CA (1) | CA2558391A1 (es) |
| IL (1) | IL177496A0 (es) |
| MX (1) | MXPA06009892A (es) |
| NO (1) | NO20064415L (es) |
| NZ (1) | NZ549254A (es) |
| TW (1) | TW200600499A (es) |
| WO (1) | WO2005087745A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| US7329676B2 (en) | 2002-08-29 | 2008-02-12 | Nycomed Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| AU2005212857B2 (en) | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| EA014155B1 (ru) | 2004-03-03 | 2010-10-29 | Никомед Гмбх | Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| AU2005281703B2 (en) | 2004-09-08 | 2011-11-17 | Takeda Gmbh | Novel 3-thia-10-aza-phenanthrene derivatives |
| EP1797098B1 (en) | 2004-09-08 | 2011-05-04 | Nycomed GmbH | 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors |
| NZ589278A (en) | 2005-03-02 | 2012-04-27 | Nycomed Gmbh | Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| RU2009120389A (ru) | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
| ES2460897T3 (es) | 2007-10-04 | 2014-05-14 | F. Hoffmann-La Roche Ag | Derivados de ciclopropil aril amida y usos de los mismos |
| KR20100113557A (ko) | 2008-01-11 | 2010-10-21 | 노파르티스 아게 | 키나제 억제제로서의 피리미딘 |
| CN102348675B (zh) | 2009-03-09 | 2014-10-01 | 巴斯夫欧洲公司 | 制备取代2-硝基联苯的方法 |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| PE20140378A1 (es) | 2011-02-25 | 2014-03-28 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1082959A1 (en) * | 1991-09-20 | 2001-03-14 | Glaxo Group Limited | NK1 Antagonists for the treatment of depression |
| US6191138B1 (en) * | 1996-01-31 | 2001-02-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines |
| US6127378A (en) * | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| ID22042A (id) * | 1996-11-11 | 1999-08-26 | Byk Gulden Lomberg Chem Fab | Benzonaftiridin sebagai pengobatan cabang tenggorokan |
| EP1000034B1 (en) * | 1997-07-25 | 2002-09-18 | ALTANA Pharma AG | Substituted 6-alkylphenanthridines |
| EP1000035B1 (en) * | 1997-07-25 | 2002-11-27 | ALTANA Pharma AG | Substituted 6-phenylphenanthridines |
| WO1999005111A1 (en) * | 1997-07-25 | 1999-02-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazole derivatives |
| PT1075477E (pt) * | 1998-05-05 | 2003-07-31 | Altana Pharma Ag | Novos n-oxidos de benzonaftiridina |
| PT1147087E (pt) * | 1999-01-15 | 2005-09-30 | Altana Pharma Ag | Feantridina-n-oxidos com actividade de inibicao de pde-iv |
| DK1147089T3 (da) * | 1999-01-15 | 2006-04-10 | Altana Pharma Ag | Phenylphenanthridiner med PDE-IV-inhiberende virkning |
| CA2359449A1 (en) * | 1999-01-15 | 2000-07-20 | Beate Gutterer | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| EP1303506B1 (en) * | 2000-07-14 | 2005-02-02 | ALTANA Pharma AG | 6-heteroarylphenanthridines |
| AU2002253045B2 (en) * | 2001-02-21 | 2007-07-12 | Takeda Gmbh | 6-phenylbenzonaphthyridines |
| EP1537086A2 (en) * | 2002-08-17 | 2005-06-08 | ALTANA Pharma AG | Novel phenanthridines |
| US7329676B2 (en) * | 2002-08-29 | 2008-02-12 | Nycomed Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| CA2496459C (en) * | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| US20060110819A1 (en) * | 2002-09-30 | 2006-05-25 | Lomas Lee O | Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| AU2005220034A1 (en) * | 2004-03-09 | 2005-09-15 | Nycomed Gmbh | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| EP1725533A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel thio containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| EP1725532A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| AU2006210231A1 (en) * | 2005-02-01 | 2006-08-10 | Nycomed Gmbh | Novel 6-pyridylphenanthridines |
| AU2006219862A1 (en) * | 2005-03-02 | 2006-09-08 | Nycomed Gmbh | 6-Heteroaryl-1,2,3,4,4a, 10b-hexahydro-phenanthridines as PDE-4 inhibitors for the treatment of inflammatory disorders |
| NZ589278A (en) * | 2005-03-02 | 2012-04-27 | Nycomed Gmbh | Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| CA2599368A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
-
2005
- 2005-03-09 EP EP05740073A patent/EP1725534A1/en not_active Withdrawn
- 2005-03-09 AU AU2005221832A patent/AU2005221832A1/en not_active Abandoned
- 2005-03-09 CA CA002558391A patent/CA2558391A1/en not_active Abandoned
- 2005-03-09 JP JP2007502343A patent/JP2007527901A/ja not_active Withdrawn
- 2005-03-09 KR KR1020067020318A patent/KR20060130697A/ko not_active Application Discontinuation
- 2005-03-09 BR BRPI0508481-4A patent/BRPI0508481A/pt not_active IP Right Cessation
- 2005-03-09 CN CN2005800068554A patent/CN1926113B/zh not_active Expired - Fee Related
- 2005-03-09 MX MXPA06009892A patent/MXPA06009892A/es not_active Application Discontinuation
- 2005-03-09 US US10/591,480 patent/US20070185149A1/en not_active Abandoned
- 2005-03-09 NZ NZ549254A patent/NZ549254A/en unknown
- 2005-03-09 WO PCT/EP2005/051054 patent/WO2005087745A1/en active Application Filing
- 2005-03-10 TW TW094107344A patent/TW200600499A/zh unknown
- 2005-03-11 AR ARP050100931A patent/AR049324A1/es unknown
-
2006
- 2006-08-15 IL IL177496A patent/IL177496A0/en unknown
- 2006-09-29 NO NO20064415A patent/NO20064415L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06009892A (es) | 2007-03-01 |
| KR20060130697A (ko) | 2006-12-19 |
| JP2007527901A (ja) | 2007-10-04 |
| WO2005087745A1 (en) | 2005-09-22 |
| CN1926113A (zh) | 2007-03-07 |
| NO20064415L (no) | 2006-10-10 |
| CN1926113B (zh) | 2010-06-23 |
| AU2005221832A1 (en) | 2005-09-22 |
| CA2558391A1 (en) | 2005-09-22 |
| IL177496A0 (en) | 2006-12-10 |
| BRPI0508481A (pt) | 2007-07-31 |
| US20070185149A1 (en) | 2007-08-09 |
| AR049324A1 (es) | 2006-07-19 |
| EP1725534A1 (en) | 2006-11-29 |
| WO2005087745A8 (en) | 2006-10-26 |
| TW200600499A (en) | 2006-01-01 |
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Owner name: NYCOMED GMBH, DE Free format text: OLD OWNER(S): ALTANA PHARMA AG |
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| PSEA | Patent sealed |