NZ549219A - Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof - Google Patents

Info

Publication number

NZ549219A

NZ549219A NZ549219A NZ54921905A NZ549219A NZ 549219 A NZ549219 A NZ 549219A NZ 549219 A NZ549219 A NZ 549219A NZ 54921905 A NZ54921905 A NZ 54921905A NZ 549219 A NZ549219 A NZ 549219A

Authority

NZ

New Zealand

Prior art keywords

group

inhibitor

alkyl

insulin

alkoxy

Prior art date

2004-03-04

Links

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• 125000000623 heterocyclic group Chemical group 0.000 title claims description 47
• 150000001875 compounds Chemical class 0.000 claims abstract description 100
• 125000001424 substituent group Chemical group 0.000 claims abstract description 57
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• 150000003839 salts Chemical class 0.000 claims abstract description 44
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• 201000009104 prediabetes syndrome Diseases 0.000 claims abstract description 37
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 31
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 28
• 239000003814 drug Substances 0.000 claims abstract description 25
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• 125000000217 alkyl group Chemical group 0.000 claims description 243
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• 125000003545 alkoxy group Chemical group 0.000 claims description 124
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 97
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 85
• -1 EGB-761 Chemical compound 0.000 claims description 70
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 69
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• PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 20
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