JP5078350B2 - 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 - Google Patents
縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 Download PDFInfo
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- JP5078350B2 JP5078350B2 JP2006510804A JP2006510804A JP5078350B2 JP 5078350 B2 JP5078350 B2 JP 5078350B2 JP 2006510804 A JP2006510804 A JP 2006510804A JP 2006510804 A JP2006510804 A JP 2006510804A JP 5078350 B2 JP5078350 B2 JP 5078350B2
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- AALUTIYNYXEFNT-UHFFFAOYSA-N trimethylsilane hydroiodide Chemical compound C[SiH](C)C.I AALUTIYNYXEFNT-UHFFFAOYSA-N 0.000 description 1
- UHLOVGKIEARANS-QZHINBJYSA-N tripamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(=O)NN2C[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3C2)=C1 UHLOVGKIEARANS-QZHINBJYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006510804A JP5078350B2 (ja) | 2004-03-04 | 2005-03-03 | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004061429 | 2004-03-04 | ||
| JP2004061429 | 2004-03-04 | ||
| JP2006510804A JP5078350B2 (ja) | 2004-03-04 | 2005-03-03 | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
| PCT/JP2005/004152 WO2005085265A1 (ja) | 2004-03-04 | 2005-03-03 | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2005085265A1 JPWO2005085265A1 (ja) | 2008-01-17 |
| JP5078350B2 true JP5078350B2 (ja) | 2012-11-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006510804A Expired - Fee Related JP5078350B2 (ja) | 2004-03-04 | 2005-03-03 | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7732596B2 (https=) |
| EP (1) | EP1724277A4 (https=) |
| JP (1) | JP5078350B2 (https=) |
| KR (1) | KR101214433B1 (https=) |
| CN (1) | CN1934122B (https=) |
| AU (1) | AU2005219777B2 (https=) |
| CA (1) | CA2557320C (https=) |
| IL (1) | IL177513A (https=) |
| MA (1) | MA28512B1 (https=) |
| NO (1) | NO20064412L (https=) |
| NZ (1) | NZ549219A (https=) |
| PL (1) | PL381247A1 (https=) |
| RU (1) | RU2387663C2 (https=) |
| TW (1) | TW200540167A (https=) |
| WO (1) | WO2005085265A1 (https=) |
| ZA (1) | ZA200606792B (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE557013T1 (de) | 2004-03-16 | 2012-05-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzol-derivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| CA2587639A1 (en) | 2004-12-16 | 2006-06-22 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| ATE445608T1 (de) | 2005-02-23 | 2009-10-15 | Boehringer Ingelheim Int | Glucopyranosylsubstituierte ((hetero)arylethynyl- benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters typ 2 (sglt2) |
| ATE453656T1 (de) | 2005-04-15 | 2010-01-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte (heteroaryloxy- benzyl)-benzen-derivate als sglt-inhibitoren |
| UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| US7723309B2 (en) | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| ES2346347T3 (es) | 2005-07-27 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Derivados de ((hetero)cicloalquiletinil-bencil)-benceno y su uso como inhibidores del cotransportador de glucosa dependiente de sodio (sglt). |
| CA2620566A1 (en) | 2005-08-30 | 2007-03-08 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| TW200745075A (en) | 2005-09-08 | 2007-12-16 | Boehringer Ingelheim Int | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments |
| AR056195A1 (es) | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
| WO2007093610A1 (en) | 2006-02-15 | 2007-08-23 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture |
| PE20080697A1 (es) | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| TWI403516B (zh) | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
| TWI432446B (zh) | 2006-07-27 | 2014-04-01 | Chugai Pharmaceutical Co Ltd | 稠環螺酮縮醇衍生物、及其做為糖尿病治療藥之使用 |
| TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| US20100093744A1 (en) * | 2006-10-13 | 2010-04-15 | Chugai Seiyaku Kabushiki Kaisha | Thioglucose spiroketal derivative and use thereof as therapeutic agent for diabetes |
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- 2005-03-03 EP EP05720423A patent/EP1724277A4/en not_active Withdrawn
- 2005-03-03 ZA ZA200606792A patent/ZA200606792B/xx unknown
- 2005-03-03 AU AU2005219777A patent/AU2005219777B2/en not_active Ceased
- 2005-03-03 CA CA2557320A patent/CA2557320C/en not_active Expired - Fee Related
- 2005-03-03 RU RU2006131552/04A patent/RU2387663C2/ru not_active IP Right Cessation
- 2005-03-03 CN CN2005800062115A patent/CN1934122B/zh not_active Expired - Fee Related
- 2005-03-03 WO PCT/JP2005/004152 patent/WO2005085265A1/ja not_active Ceased
- 2005-03-03 US US10/591,403 patent/US7732596B2/en not_active Expired - Fee Related
- 2005-03-03 PL PL381247A patent/PL381247A1/pl not_active Application Discontinuation
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- 2006-08-16 IL IL177513A patent/IL177513A/en not_active IP Right Cessation
- 2006-09-20 KR KR1020067019362A patent/KR101214433B1/ko not_active Expired - Fee Related
- 2006-09-29 NO NO20064412A patent/NO20064412L/no not_active Application Discontinuation
- 2006-10-02 MA MA29361A patent/MA28512B1/fr unknown
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| JP2003012686A (ja) * | 2001-07-02 | 2003-01-15 | Kyowa Hakko Kogyo Co Ltd | ピラゾール誘導体 |
| WO2003087093A1 (en) * | 2002-04-08 | 2003-10-23 | Council Of Scientific And Industrial Research | Novel glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2557320A1 (en) | 2005-09-15 |
| RU2006131552A (ru) | 2008-03-10 |
| US7732596B2 (en) | 2010-06-08 |
| HK1099556A1 (zh) | 2007-08-17 |
| US20070197449A1 (en) | 2007-08-23 |
| IL177513A (en) | 2011-11-30 |
| WO2005085265A1 (ja) | 2005-09-15 |
| IL177513A0 (en) | 2006-12-10 |
| PL381247A1 (pl) | 2007-05-14 |
| AU2005219777A1 (en) | 2005-09-15 |
| CN1934122B (zh) | 2010-08-04 |
| EP1724277A1 (en) | 2006-11-22 |
| AU2005219777B2 (en) | 2011-02-03 |
| KR20060132737A (ko) | 2006-12-21 |
| JPWO2005085265A1 (ja) | 2008-01-17 |
| NO20064412L (no) | 2006-12-04 |
| CN1934122A (zh) | 2007-03-21 |
| NZ549219A (en) | 2010-08-27 |
| KR101214433B1 (ko) | 2012-12-21 |
| ZA200606792B (en) | 2007-12-27 |
| MA28512B1 (fr) | 2007-04-03 |
| RU2387663C2 (ru) | 2010-04-27 |
| EP1724277A4 (en) | 2012-05-02 |
| TW200540167A (en) | 2005-12-16 |
| TWI361190B (https=) | 2012-04-01 |
| CA2557320C (en) | 2013-02-05 |
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