NZ539329A - Method of using (2-imidazolin-2-ylamino) quinoxalines in the treatment of dementia and parkinsons - Google Patents
Method of using (2-imidazolin-2-ylamino) quinoxalines in the treatment of dementia and parkinsonsInfo
- Publication number
- NZ539329A NZ539329A NZ539329A NZ53932903A NZ539329A NZ 539329 A NZ539329 A NZ 539329A NZ 539329 A NZ539329 A NZ 539329A NZ 53932903 A NZ53932903 A NZ 53932903A NZ 539329 A NZ539329 A NZ 539329A
- Authority
- NZ
- New Zealand
- Prior art keywords
- neurons
- alpha
- brimonidine
- apoptosis
- brain
- Prior art date
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- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000004895 regional blood flow Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- IYETZZCWLLUHIJ-UTONKHPSSA-N selegiline hydrochloride Chemical compound [Cl-].C#CC[NH+](C)[C@H](C)CC1=CC=CC=C1 IYETZZCWLLUHIJ-UTONKHPSSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002813 septal nuclei Anatomy 0.000 description 1
- 230000000862 serotonergic effect Effects 0.000 description 1
- 230000007727 signaling mechanism Effects 0.000 description 1
- 229940001089 sinemet Drugs 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229960004249 sodium acetate Drugs 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 210000000331 sympathetic ganglia Anatomy 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001685 tacrine Drugs 0.000 description 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 108010088556 tau protein kinase II Proteins 0.000 description 1
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
- 229960001693 terazosin Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 239000000225 tumor suppressor protein Substances 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 210000000857 visual cortex Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41703102P | 2002-10-08 | 2002-10-08 | |
| PCT/US2003/031842 WO2004032934A1 (en) | 2002-10-08 | 2003-10-07 | Method of using (2-imidazolin-2-ylamino) qinoxalines in the treatment of dementia and parkinsons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ539329A true NZ539329A (en) | 2007-11-30 |
Family
ID=32093952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ539329A NZ539329A (en) | 2002-10-08 | 2003-10-07 | Method of using (2-imidazolin-2-ylamino) quinoxalines in the treatment of dementia and parkinsons |
Country Status (20)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7512436B2 (en) * | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US20100298305A1 (en) * | 2008-11-26 | 2010-11-25 | The United States Government, As Represented By The Department Of Veterans Affairs | Tizanidine for the treatment of post-traumatic stress disorder and nightmares |
| DE102009043750A1 (de) * | 2009-09-30 | 2011-08-04 | Carl Zeiss Meditec AG, 07745 | Verfahren und Vorrichtung zur Detektion von Ablagerungen im Auge |
| US10022341B2 (en) * | 2014-12-02 | 2018-07-17 | Yale University | Methods of preventing neurodegeneration of association cortex in a mammal |
| RU2680526C1 (ru) * | 2016-07-05 | 2019-02-22 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Нейропротекторное средство, обладающее свойствами антиоксиданта и донатора оксида азота |
| JP2019526055A (ja) * | 2016-08-01 | 2019-09-12 | コグノプティックス， インコーポレイテッド | 眼組織におけるタウタンパク質を検出するためのシステムおよび方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US5210076A (en) * | 1988-09-13 | 1993-05-11 | Berliner David L | Methods of treating Parkinson's disease using melanin |
| DK0828513T3 (da) * | 1995-05-26 | 2004-04-13 | Pfizer | Kombinationspræparater til behandling af parkinsonisme, indeholdende selektive NMDA-antagonister |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| US6329369B1 (en) * | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
| PT1036065E (pt) * | 1997-12-04 | 2004-09-30 | Allergan Inc | Derivados de imidazol substituidos com actividade do tipo agonista nos receptores alfa 2b ou 2b/2c adrenergicos |
| US6313172B1 (en) * | 2000-04-13 | 2001-11-06 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| EP1365811A2 (en) * | 2000-07-14 | 2003-12-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
-
2003
- 2003-10-07 JP JP2004543508A patent/JP2006504741A/ja active Pending
- 2003-10-07 US US10/680,996 patent/US20040116436A1/en not_active Abandoned
- 2003-10-07 HK HK06100172.4A patent/HK1080408B/en not_active IP Right Cessation
- 2003-10-07 DE DE60318081T patent/DE60318081T2/de not_active Expired - Lifetime
- 2003-10-07 RU RU2005114505/14A patent/RU2332218C2/ru not_active IP Right Cessation
- 2003-10-07 EP EP03773199A patent/EP1549314B1/en not_active Expired - Lifetime
- 2003-10-07 KR KR1020057006115A patent/KR20050056235A/ko not_active Ceased
- 2003-10-07 BR BR0314541-7A patent/BR0314541A/pt not_active IP Right Cessation
- 2003-10-07 CA CA002501348A patent/CA2501348A1/en not_active Abandoned
- 2003-10-07 ES ES03773199T patent/ES2297233T3/es not_active Expired - Lifetime
- 2003-10-07 AU AU2003279874A patent/AU2003279874A1/en not_active Abandoned
- 2003-10-07 MX MXPA05003665A patent/MXPA05003665A/es active IP Right Grant
- 2003-10-07 WO PCT/US2003/031842 patent/WO2004032934A1/en not_active Ceased
- 2003-10-07 AT AT03773199T patent/ATE380551T1/de not_active IP Right Cessation
- 2003-10-07 NZ NZ539329A patent/NZ539329A/en not_active IP Right Cessation
- 2003-10-07 CN CNB2003801011164A patent/CN100370988C/zh not_active Expired - Fee Related
- 2003-10-07 PL PL03376347A patent/PL376347A1/xx not_active Application Discontinuation
-
2005
- 2005-04-04 NO NO20051664A patent/NO20051664L/no not_active Application Discontinuation
- 2005-04-04 IL IL167848A patent/IL167848A/en not_active IP Right Cessation
- 2005-04-05 ZA ZA200502745A patent/ZA200502745B/en unknown
-
2010
- 2010-02-26 AU AU2010200730A patent/AU2010200730A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2005114505A (ru) | 2005-10-27 |
| IL167848A (en) | 2010-11-30 |
| ATE380551T1 (de) | 2007-12-15 |
| EP1549314B1 (en) | 2007-12-12 |
| CN100370988C (zh) | 2008-02-27 |
| ZA200502745B (en) | 2006-07-26 |
| WO2004032934A1 (en) | 2004-04-22 |
| ES2297233T3 (es) | 2008-05-01 |
| PL376347A1 (en) | 2005-12-27 |
| CN1703222A (zh) | 2005-11-30 |
| US20040116436A1 (en) | 2004-06-17 |
| AU2003279874A1 (en) | 2004-05-04 |
| MXPA05003665A (es) | 2005-06-08 |
| HK1080408B (en) | 2008-08-08 |
| DE60318081D1 (de) | 2008-01-24 |
| AU2010200730A1 (en) | 2010-03-18 |
| NO20051664L (no) | 2005-05-31 |
| HK1080408A1 (en) | 2006-04-28 |
| EP1549314A1 (en) | 2005-07-06 |
| KR20050056235A (ko) | 2005-06-14 |
| BR0314541A (pt) | 2005-07-26 |
| RU2332218C2 (ru) | 2008-08-27 |
| DE60318081T2 (de) | 2008-11-06 |
| JP2006504741A (ja) | 2006-02-09 |
| CA2501348A1 (en) | 2004-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |