NZ511572A - Eudesmadienolide derivatives useful as glucose and lipid lowering compounds - Google Patents

Eudesmadienolide derivatives useful as glucose and lipid lowering compounds

Info

Publication number
NZ511572A
NZ511572A NZ511572A NZ51157299A NZ511572A NZ 511572 A NZ511572 A NZ 511572A NZ 511572 A NZ511572 A NZ 511572A NZ 51157299 A NZ51157299 A NZ 51157299A NZ 511572 A NZ511572 A NZ 511572A
Authority
NZ
New Zealand
Prior art keywords
hydroxy
carbon
substituted
alkyl
eudesmadienolide
Prior art date
Application number
NZ511572A
Other languages
English (en)
Inventor
Dilip Wagle
Sheng Ding Fang
Ihor Terleckyj
John Resek
Jack Egan
Michael Lankin
David H Shih
Original Assignee
Alteon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alteon Inc filed Critical Alteon Inc
Publication of NZ511572A publication Critical patent/NZ511572A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ511572A 1998-11-12 1999-11-10 Eudesmadienolide derivatives useful as glucose and lipid lowering compounds NZ511572A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19050798A 1998-11-12 1998-11-12
US19735298A 1998-11-20 1998-11-20
PCT/US1999/026563 WO2000027388A1 (en) 1998-11-12 1999-11-10 Glucose and lipid lowering compounds

Publications (1)

Publication Number Publication Date
NZ511572A true NZ511572A (en) 2003-06-30

Family

ID=26886182

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ511572A NZ511572A (en) 1998-11-12 1999-11-10 Eudesmadienolide derivatives useful as glucose and lipid lowering compounds

Country Status (8)

Country Link
EP (1) EP1135119A4 (xx)
JP (1) JP2002529409A (xx)
KR (1) KR20010080428A (xx)
AU (1) AU761878B2 (xx)
CA (1) CA2350213A1 (xx)
MX (1) MXPA01004830A (xx)
NZ (1) NZ511572A (xx)
WO (1) WO2000027388A1 (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2286451A1 (en) * 1999-10-14 2001-04-14 Grant A. Mitchell Hormone-sensitive lipase mediated male infertility
WO2004111006A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Para-subtituted phenyl carbamates as inhibitors of hormone sensitive lipase
JP2006527215A (ja) * 2003-06-12 2006-11-30 ノボ　ノルディスク　アクティーゼルスカブ パラ置換されたフェニルカルバメート
AU2005317748B8 (en) * 2004-12-23 2011-07-21 Caroline Van Haaften Therapeutic compounds isolated from Calomeria amaranthoides
ES2324051T3 (es) 2004-12-23 2009-07-29 Caroline Van Haaften Extractos terapeuticos obtenidos a partir de calomeria amarnthoides y sus usos.
CN114886889A (zh) * 2022-04-27 2022-08-12 清华大学 土木香内酯或其衍生物在制备用于预防或治疗肥胖的药物、保健品或食品中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69211994T2 (de) * 1991-10-17 1997-02-20 Shionogi & Co Lignan-analoge, ihre herstellung und hypolipidemische arzneimittel
US5917084A (en) * 1996-07-03 1999-06-29 Millennium Pharmaceuticals, Inc. Antifungal agents

Also Published As

Publication number Publication date
WO2000027388A1 (en) 2000-05-18
JP2002529409A (ja) 2002-09-10
CA2350213A1 (en) 2000-05-18
EP1135119A1 (en) 2001-09-26
KR20010080428A (ko) 2001-08-22
EP1135119A4 (en) 2004-11-03
MXPA01004830A (es) 2002-09-18
AU761878B2 (en) 2003-06-12
AU1522600A (en) 2000-05-29

Similar Documents

Publication Publication Date Title
EA200101194A1 (ru) Производные 4,5,6,7-тетрагидроиндазола в качестве противоопухолевых средств
DE3270307D1 (en) Succinimide derivates and process for preparation thereof
RU95101430A (ru) Производные 1-бифенилметилимидазола, их получение, фармацевтическая композиция, способ лечения или профилактики гипертонии
PL343419A1 (en) Benzofurylpyrone derivatives
EP1103552A4 (en) BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
ES8605506A1 (es) Procedimiento para preparar derivados de piperidina
NO951318D0 (no) 25-carboxylsyrederivater i vitamin D-serien, fremgangsmåte for fremstilling av disse, mellomprodukter for fremgangsmåten, farmasöytiske preparater inneholdende disse derivater og deres anvendelse ved fremstilling av medisiner
MY123467A (en) Preparation of sterically hindered amine ethers
DE69223827D1 (de) Glycyrrheticsäurederivate
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
GR3020682T3 (en) Use of dioxabicyclo [3.3.0]octane derivatives for the manufacture of a medicament for inhibiting the metabolism of cholesterol.
NZ511572A (en) Eudesmadienolide derivatives useful as glucose and lipid lowering compounds
AU5157679A (en) Isatin derivatives
IT1265077B1 (it) Derivati del cicloeptimmidazolo, metodo per la loro produzione e agenti terapeutici contenenti questi composti
IE42411L (en) Trimethylsilyl acetylene derivatives
AU5704586A (en) Hexenoic acids
CA2208520A1 (en) Diclavulanate salt with a diamino ether and process of preparation
EA200101050A1 (ru) Замещенные бензолактамные соединения
TW353071B (en) Chromene compounds with neutroleptic activity, their preparation and pharmaceutical compositions
ATE70825T1 (de) 3-oxo-2-azabicyclohexan-derivate, verfahren zu ihrer herstellung und verwendung dieser derivate als zwischenverbindungen fuer antibakterielle wirkstoffe.
PL353863A1 (en) Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents
TW337522B (en) Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid derivatives, process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)