NZ511572A - Eudesmadienolide derivatives useful as glucose and lipid lowering compounds - Google Patents

Eudesmadienolide derivatives useful as glucose and lipid lowering compounds

Info

Publication number
NZ511572A
NZ511572A NZ511572A NZ51157299A NZ511572A NZ 511572 A NZ511572 A NZ 511572A NZ 511572 A NZ511572 A NZ 511572A NZ 51157299 A NZ51157299 A NZ 51157299A NZ 511572 A NZ511572 A NZ 511572A
Authority
NZ
New Zealand
Prior art keywords
hydroxy
carbon
substituted
alkyl
eudesmadienolide
Prior art date
Application number
NZ511572A
Other languages
English (en)
Inventor
Dilip Wagle
Sheng Ding Fang
Ihor Terleckyj
John Resek
Jack Egan
Michael Lankin
David H Shih
Original Assignee
Alteon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alteon Inc filed Critical Alteon Inc
Publication of NZ511572A publication Critical patent/NZ511572A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ511572A 1998-11-12 1999-11-10 Eudesmadienolide derivatives useful as glucose and lipid lowering compounds NZ511572A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19050798A 1998-11-12 1998-11-12
US19735298A 1998-11-20 1998-11-20
PCT/US1999/026563 WO2000027388A1 (fr) 1998-11-12 1999-11-10 Composes hypoglycemiants et hypolipemiants

Publications (1)

Publication Number Publication Date
NZ511572A true NZ511572A (en) 2003-06-30

Family

ID=26886182

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ511572A NZ511572A (en) 1998-11-12 1999-11-10 Eudesmadienolide derivatives useful as glucose and lipid lowering compounds

Country Status (8)

Country Link
EP (1) EP1135119A4 (fr)
JP (1) JP2002529409A (fr)
KR (1) KR20010080428A (fr)
AU (1) AU761878B2 (fr)
CA (1) CA2350213A1 (fr)
MX (1) MXPA01004830A (fr)
NZ (1) NZ511572A (fr)
WO (1) WO2000027388A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2286451A1 (fr) 1999-10-14 2001-04-14 Grant A. Mitchell Induction de l'infertilite chez les males au moyen d'une lipase hormonosensible
JP2006527215A (ja) * 2003-06-12 2006-11-30 ノボ　ノルディスク　アクティーゼルスカブ パラ置換されたフェニルカルバメート
WO2004111006A1 (fr) * 2003-06-12 2004-12-23 Novo Nordisk A/S Carbamates de phenyle para-substitues en tant qu'inhibiteurs de la lipase hormono-sensible
WO2006067603A1 (fr) * 2004-12-23 2006-06-29 Caroline Van Haaften Composes therapeutiques
AU2005317748B8 (en) * 2004-12-23 2011-07-21 Caroline Van Haaften Therapeutic compounds isolated from Calomeria amaranthoides
CN114886889A (zh) * 2022-04-27 2022-08-12 清华大学 土木香内酯或其衍生物在制备用于预防或治疗肥胖的药物、保健品或食品中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2839805B2 (ja) * 1991-10-17 1998-12-16 塩野義製薬株式会社 リグナン類縁体及びその製造方法ならびに抗高脂血症剤
US5917084A (en) * 1996-07-03 1999-06-29 Millennium Pharmaceuticals, Inc. Antifungal agents

Also Published As

Publication number Publication date
CA2350213A1 (fr) 2000-05-18
AU761878B2 (en) 2003-06-12
JP2002529409A (ja) 2002-09-10
EP1135119A1 (fr) 2001-09-26
EP1135119A4 (fr) 2004-11-03
AU1522600A (en) 2000-05-29
WO2000027388A1 (fr) 2000-05-18
MXPA01004830A (es) 2002-09-18
KR20010080428A (ko) 2001-08-22

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Legal Events

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