NZ511450A - Method of identifying compounds that modulate the function of the human hypoxia-inducible factor 1-alpha (HIF-1alpha) functional domain - Google Patents

Method of identifying compounds that modulate the function of the human hypoxia-inducible factor 1-alpha (HIF-1alpha) functional domain

Info

Publication number
NZ511450A
NZ511450A NZ511450A NZ51145099A NZ511450A NZ 511450 A NZ511450 A NZ 511450A NZ 511450 A NZ511450 A NZ 511450A NZ 51145099 A NZ51145099 A NZ 51145099A NZ 511450 A NZ511450 A NZ 511450A
Authority
NZ
New Zealand
Prior art keywords
hif
leu
ser
thr
glu
Prior art date
Application number
NZ511450A
Other languages
English (en)
Inventor
Anders Berkenstam
Lorenz Poellinger
Original Assignee
Angiogenetics Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiogenetics Ab filed Critical Angiogenetics Ab
Publication of NZ511450A publication Critical patent/NZ511450A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Lasers (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Amplifiers (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
NZ511450A 1998-11-13 1999-11-11 Method of identifying compounds that modulate the function of the human hypoxia-inducible factor 1-alpha (HIF-1alpha) functional domain NZ511450A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants
PCT/SE1999/002053 WO2000029437A1 (en) 1998-11-13 1999-11-11 HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS

Publications (1)

Publication Number Publication Date
NZ511450A true NZ511450A (en) 2003-08-29

Family

ID=20413284

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ511450A NZ511450A (en) 1998-11-13 1999-11-11 Method of identifying compounds that modulate the function of the human hypoxia-inducible factor 1-alpha (HIF-1alpha) functional domain

Country Status (15)

Country Link
EP (1) EP1141005B1 (zh)
JP (1) JP2002530063A (zh)
KR (1) KR100648761B1 (zh)
CN (1) CN1330666C (zh)
AT (1) ATE374210T1 (zh)
AU (1) AU761594B2 (zh)
BR (1) BR9915263A (zh)
CA (1) CA2350830A1 (zh)
DE (1) DE69937199D1 (zh)
HK (1) HK1043372B (zh)
NZ (1) NZ511450A (zh)
SE (1) SE9803891D0 (zh)
TR (1) TR200101345T2 (zh)
WO (1) WO2000029437A1 (zh)
ZA (1) ZA200103669B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) * 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ATE383877T1 (de) * 1999-06-04 2008-02-15 Dana Farber Cancer Inst Inc Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren
AU6503901A (en) * 2000-05-26 2001-12-11 Univ Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
AU2001290179B2 (en) * 2000-08-07 2007-07-12 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
US7608698B2 (en) 2001-05-23 2009-10-27 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
WO2003064587A2 (en) * 2002-01-11 2003-08-07 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
ZA200103669B (en) 2002-05-07
BR9915263A (pt) 2001-10-30
TR200101345T2 (tr) 2001-10-22
KR20010080411A (ko) 2001-08-22
CN1330663A (zh) 2002-01-09
KR100648761B1 (ko) 2006-11-23
JP2002530063A (ja) 2002-09-17
AU761594B2 (en) 2003-06-05
EP1141005B1 (en) 2007-09-26
AU1593100A (en) 2000-06-05
ATE374210T1 (de) 2007-10-15
DE69937199D1 (de) 2007-11-08
EP1141005A1 (en) 2001-10-10
WO2000029437A1 (en) 2000-05-25
HK1043372B (zh) 2008-05-09
SE9803891D0 (sv) 1998-11-13
CA2350830A1 (en) 2000-05-25
CN1330666C (zh) 2007-08-08
HK1043372A1 (en) 2002-09-13

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Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: BIOVITRUM AB, SE

Free format text: OLD OWNER(S): PHARMACIA AB

ASS Change of ownership

Owner name: ANGIOGENETICS AB, SE

Free format text: OLD OWNER(S): BIOVITRUM AB

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