KR100648761B1 - 저산소증-유도성 인자 1α ＨＩＦ-1α 변이체 및ＨＩＦ-1α 조절제의 동정 방법 - Google Patents

저산소증-유도성 인자 1α ＨＩＦ-1α 변이체 및ＨＩＦ-1α 조절제의 동정 방법 Download PDF

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KR100648761B1
KR100648761B1 KR1020017005928A KR20017005928A KR100648761B1 KR 100648761 B1 KR100648761 B1 KR 100648761B1 KR 1020017005928 A KR1020017005928 A KR 1020017005928A KR 20017005928 A KR20017005928 A KR 20017005928A KR 100648761 B1 KR100648761 B1 KR 100648761B1
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KR1020017005928A
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KR20010080411A (ko
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베르켄스탐안데르스
포엘린거로렌츠
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앤지오제네틱스 스웨덴 에이비
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Amplifiers (AREA)
  • Semiconductor Lasers (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
KR1020017005928A 1998-11-13 1999-11-11 저산소증-유도성 인자 1α ＨＩＦ-1α 변이체 및ＨＩＦ-1α 조절제의 동정 방법 KR100648761B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9803891-2 1998-11-13
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants

Publications (2)

Publication Number Publication Date
KR20010080411A KR20010080411A (ko) 2001-08-22
KR100648761B1 true KR100648761B1 (ko) 2006-11-23

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KR1020017005928A KR100648761B1 (ko) 1998-11-13 1999-11-11 저산소증-유도성 인자 1α ＨＩＦ-1α 변이체 및ＨＩＦ-1α 조절제의 동정 방법

Country Status (15)

Country Link
EP (1) EP1141005B1 (zh)
JP (1) JP2002530063A (zh)
KR (1) KR100648761B1 (zh)
CN (1) CN1330666C (zh)
AT (1) ATE374210T1 (zh)
AU (1) AU761594B2 (zh)
BR (1) BR9915263A (zh)
CA (1) CA2350830A1 (zh)
DE (1) DE69937199D1 (zh)
HK (1) HK1043372B (zh)
NZ (1) NZ511450A (zh)
SE (1) SE9803891D0 (zh)
TR (1) TR200101345T2 (zh)
WO (1) WO2000029437A1 (zh)
ZA (1) ZA200103669B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ATE383877T1 (de) * 1999-06-04 2008-02-15 Dana Farber Cancer Inst Inc Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren
WO2001092578A2 (en) * 2000-05-26 2001-12-06 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
CA2418386A1 (en) * 2000-08-07 2002-02-14 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
WO2002094862A2 (en) 2001-05-23 2002-11-28 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
WO2003064587A2 (en) * 2002-01-11 2003-08-07 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
SE9803891D0 (sv) 1998-11-13
ATE374210T1 (de) 2007-10-15
TR200101345T2 (tr) 2001-10-22
AU761594B2 (en) 2003-06-05
JP2002530063A (ja) 2002-09-17
CA2350830A1 (en) 2000-05-25
EP1141005B1 (en) 2007-09-26
ZA200103669B (en) 2002-05-07
HK1043372A1 (en) 2002-09-13
WO2000029437A1 (en) 2000-05-25
EP1141005A1 (en) 2001-10-10
AU1593100A (en) 2000-06-05
DE69937199D1 (de) 2007-11-08
CN1330663A (zh) 2002-01-09
CN1330666C (zh) 2007-08-08
NZ511450A (en) 2003-08-29
KR20010080411A (ko) 2001-08-22
HK1043372B (zh) 2008-05-09
BR9915263A (pt) 2001-10-30

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