NZ501619A - Tricyclic sulfonamide inhibitors of farnesyl-protein transferase - Google Patents

Tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Info

Publication number
NZ501619A
NZ501619A NZ501619A NZ50161998A NZ501619A NZ 501619 A NZ501619 A NZ 501619A NZ 501619 A NZ501619 A NZ 501619A NZ 50161998 A NZ50161998 A NZ 50161998A NZ 501619 A NZ501619 A NZ 501619A
Authority
NZ
New Zealand
Prior art keywords
dihydro
benzo
pyridin
cyclohepta
piperidine
Prior art date
Application number
NZ501619A
Other languages
English (en)
Inventor
F George Njoroge
Bancha Vibulbhan
Arthur G Taveras
Ronald J Doll
Viyyoor M Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NZ501619A publication Critical patent/NZ501619A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ501619A 1997-06-17 1998-06-15 Tricyclic sulfonamide inhibitors of farnesyl-protein transferase NZ501619A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17
PCT/US1998/011508 WO1998057949A1 (fr) 1997-06-17 1998-06-15 Nouveaux sulfonamides tricycliques inhibiteurs de la farnesyle transferase

Publications (1)

Publication Number Publication Date
NZ501619A true NZ501619A (en) 2002-02-01

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ501619A NZ501619A (en) 1997-06-17 1998-06-15 Tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Country Status (14)

Country Link
EP (1) EP0989980A1 (fr)
JP (1) JP2002507192A (fr)
KR (1) KR20010013826A (fr)
CN (1) CN1267290A (fr)
AR (1) AR012989A1 (fr)
AU (1) AU8253698A (fr)
CA (1) CA2293358C (fr)
CO (1) CO4940475A1 (fr)
HU (1) HUP0004627A2 (fr)
IL (1) IL133393A0 (fr)
NZ (1) NZ501619A (fr)
PE (1) PE86199A1 (fr)
WO (1) WO1998057949A1 (fr)
ZA (1) ZA985218B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
CA2429720C (fr) * 2000-11-29 2009-12-29 Schering Corporation Composes tricycliques servant a inhiber la farnesyl proteine transferase
WO2006055187A1 (fr) 2004-10-29 2006-05-26 Kalypsys, Inc. Composes bicycliques a substitution sulfonyle, modulateurs des ppars
KR101464767B1 (ko) 2005-10-25 2014-11-24 칼립시스, 인코포레이티드 Ppar의 조절자의 염 및 대사질환을 치료하는 방법
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
BR112015019818A2 (pt) * 2013-02-19 2017-07-18 Icahn School Med Mount Sinai composto, uso de um composto, e, composição farmacêutica

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT76057A (en) * 1993-10-15 1997-06-30 Schering Corp Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
CA2293358C (fr) 2008-08-05
ZA985218B (en) 1998-12-15
AR012989A1 (es) 2000-11-22
PE86199A1 (es) 1999-09-24
CN1267290A (zh) 2000-09-20
AU8253698A (en) 1999-01-04
HUP0004627A2 (hu) 2001-10-28
CO4940475A1 (es) 2000-07-24
IL133393A0 (en) 2001-04-30
JP2002507192A (ja) 2002-03-05
KR20010013826A (ko) 2001-02-26
WO1998057949A1 (fr) 1998-12-23
CA2293358A1 (fr) 1998-12-23
EP0989980A1 (fr) 2000-04-05

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Legal Events

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