NZ336447A - process for preparing racemic omeprazole (5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole) - Google Patents

process for preparing racemic omeprazole (5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole)

Info

Publication number
NZ336447A
NZ336447A NZ336447A NZ33644798A NZ336447A NZ 336447 A NZ336447 A NZ 336447A NZ 336447 A NZ336447 A NZ 336447A NZ 33644798 A NZ33644798 A NZ 33644798A NZ 336447 A NZ336447 A NZ 336447A
Authority
NZ
New Zealand
Prior art keywords
process according
omeprazole
methoxy
prepared
titanium
Prior art date
Application number
NZ336447A
Other languages
English (en)
Inventor
Hanna Cotton
Magnus Larsson
Anders Mattson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NZ336447A publication Critical patent/NZ336447A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
NZ336447A 1997-11-14 1998-11-03 process for preparing racemic omeprazole (5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole) NZ336447A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704183A SE9704183D0 (sv) 1997-11-14 1997-11-14 New process
PCT/SE1998/001984 WO1999025711A1 (en) 1997-11-14 1998-11-03 New process

Publications (1)

Publication Number Publication Date
NZ336447A true NZ336447A (en) 2001-02-23

Family

ID=20408989

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ336447A NZ336447A (en) 1997-11-14 1998-11-03 process for preparing racemic omeprazole (5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole)

Country Status (35)

Country Link
US (1) US6303788B1 (US06559137-20030506-C00047.png)
EP (1) EP0964859A1 (US06559137-20030506-C00047.png)
JP (1) JP2001508466A (US06559137-20030506-C00047.png)
KR (1) KR20000070069A (US06559137-20030506-C00047.png)
CN (1) CN1145624C (US06559137-20030506-C00047.png)
AR (1) AR013740A1 (US06559137-20030506-C00047.png)
AU (1) AU750743B2 (US06559137-20030506-C00047.png)
BR (1) BR9806871A (US06559137-20030506-C00047.png)
CA (1) CA2276753A1 (US06559137-20030506-C00047.png)
DE (1) DE964859T1 (US06559137-20030506-C00047.png)
DZ (1) DZ2641A1 (US06559137-20030506-C00047.png)
EE (1) EE04154B1 (US06559137-20030506-C00047.png)
ES (1) ES2138950T1 (US06559137-20030506-C00047.png)
GR (1) GR990300046T1 (US06559137-20030506-C00047.png)
HR (1) HRP990218A2 (US06559137-20030506-C00047.png)
HU (1) HUP0003737A3 (US06559137-20030506-C00047.png)
ID (1) ID21999A (US06559137-20030506-C00047.png)
IL (1) IL130647A0 (US06559137-20030506-C00047.png)
IN (1) IN190801B (US06559137-20030506-C00047.png)
IS (1) IS5106A (US06559137-20030506-C00047.png)
MA (1) MA26564A1 (US06559137-20030506-C00047.png)
MY (1) MY118199A (US06559137-20030506-C00047.png)
NO (1) NO318197B1 (US06559137-20030506-C00047.png)
NZ (1) NZ336447A (US06559137-20030506-C00047.png)
PL (1) PL334701A1 (US06559137-20030506-C00047.png)
RU (1) RU2211218C2 (US06559137-20030506-C00047.png)
SE (1) SE9704183D0 (US06559137-20030506-C00047.png)
SK (1) SK87299A3 (US06559137-20030506-C00047.png)
TN (1) TNSN98202A1 (US06559137-20030506-C00047.png)
TR (1) TR199901643T1 (US06559137-20030506-C00047.png)
TW (1) TW588046B (US06559137-20030506-C00047.png)
UA (1) UA68342C2 (US06559137-20030506-C00047.png)
WO (1) WO1999025711A1 (US06559137-20030506-C00047.png)
YU (1) YU31199A (US06559137-20030506-C00047.png)
ZA (1) ZA989999B (US06559137-20030506-C00047.png)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
WO2002062786A1 (en) * 2001-02-02 2002-08-15 Teva Pharmaceutical Industries Ltd. Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
DE602005016705D1 (de) * 2004-10-11 2009-10-29 Ranbaxy Lab Ltd Verfahren zur herstellung substituierter sulfoxide
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
CN1810803B (zh) * 2006-02-17 2010-11-17 中国科学院上海有机化学研究所 高对映体选择性制备(s)-奥美拉唑的方法
CN101538264A (zh) * 2008-03-19 2009-09-23 中国科学院成都有机化学有限公司 手性亚砜类化合物的制备新方法
CN102603621B (zh) * 2012-02-07 2013-09-04 成都苑东药业有限公司 一种新型手性亚砜化合物和以该化合物制备埃索美拉唑钠的方法
CN106083819A (zh) * 2016-06-08 2016-11-09 扬子江药业集团有限公司 一种奥美拉唑的制备方法
ES2948511A1 (es) * 2021-09-08 2023-09-13 Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa Derivados de n-sulfonilureas y su uso terapeutico

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE504459C2 (sv) 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider

Also Published As

Publication number Publication date
CN1145624C (zh) 2004-04-14
CN1243512A (zh) 2000-02-02
UA68342C2 (en) 2004-08-16
NO318197B1 (no) 2005-02-14
DZ2641A1 (fr) 2003-03-15
HUP0003737A2 (hu) 2001-10-28
IL130647A0 (en) 2000-06-01
AU1058299A (en) 1999-06-07
YU31199A (sh) 2002-06-19
AU750743B2 (en) 2002-07-25
TNSN98202A1 (fr) 2005-03-15
NO993298L (no) 1999-07-02
PL334701A1 (en) 2000-03-13
BR9806871A (pt) 2000-04-18
MA26564A1 (fr) 2004-12-20
EE04154B1 (et) 2003-10-15
IS5106A (is) 1999-07-02
GR990300046T1 (en) 2000-07-31
ES2138950T1 (es) 2000-02-01
MY118199A (en) 2004-09-30
EE9900391A (et) 2000-04-17
DE964859T1 (de) 2000-05-04
KR20000070069A (ko) 2000-11-25
SE9704183D0 (sv) 1997-11-14
ID21999A (id) 1999-08-19
AR013740A1 (es) 2001-01-10
US6303788B1 (en) 2001-10-16
WO1999025711A1 (en) 1999-05-27
SK87299A3 (en) 2000-02-14
ZA989999B (en) 1999-06-17
TR199901643T1 (xx) 2000-01-21
NO993298D0 (no) 1999-07-02
JP2001508466A (ja) 2001-06-26
HUP0003737A3 (en) 2002-01-28
HRP990218A2 (en) 2000-08-31
CA2276753A1 (en) 1999-05-27
TW588046B (en) 2004-05-21
RU2211218C2 (ru) 2003-08-27
EP0964859A1 (en) 1999-12-22
IN190801B (US06559137-20030506-C00047.png) 2003-08-23

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