NZ334065A - Compositions containing hedgehog proteins bound to a hydrophilic carrier for use in the local release of these proteins on bone and cartilage - Google Patents
Compositions containing hedgehog proteins bound to a hydrophilic carrier for use in the local release of these proteins on bone and cartilageInfo
- Publication number
- NZ334065A NZ334065A NZ334065A NZ33406599A NZ334065A NZ 334065 A NZ334065 A NZ 334065A NZ 334065 A NZ334065 A NZ 334065A NZ 33406599 A NZ33406599 A NZ 33406599A NZ 334065 A NZ334065 A NZ 334065A
- Authority
- NZ
- New Zealand
- Prior art keywords
- carrier
- hedgehog protein
- pharmaceutical composition
- hedgehog
- protein
- Prior art date
Links
- 102000003693 Hedgehog Proteins Human genes 0.000 title claims abstract description 77
- 108090000031 Hedgehog Proteins Proteins 0.000 title claims abstract description 77
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 210000000988 bone and bone Anatomy 0.000 title abstract description 7
- 239000012052 hydrophilic carrier Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title description 35
- 102000004169 proteins and genes Human genes 0.000 title description 34
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 10
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 8
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- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
- 229960005314 suramin Drugs 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98101893 | 1998-02-04 | ||
| EP98104416 | 1998-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ334065A true NZ334065A (en) | 2000-06-23 |
Family
ID=26149005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ334065A NZ334065A (en) | 1998-02-04 | 1999-02-04 | Compositions containing hedgehog proteins bound to a hydrophilic carrier for use in the local release of these proteins on bone and cartilage |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP3092706B2 (cs) |
| KR (2) | KR100311565B1 (cs) |
| CN (1) | CN1228994A (cs) |
| AT (1) | ATE331533T1 (cs) |
| AU (1) | AU713568B2 (cs) |
| CA (1) | CA2260423C (cs) |
| CZ (1) | CZ33799A3 (cs) |
| DE (1) | DE69932113T2 (cs) |
| HU (1) | HUP9900251A3 (cs) |
| IL (1) | IL128329A (cs) |
| MA (1) | MA26602A1 (cs) |
| NO (1) | NO990471L (cs) |
| NZ (1) | NZ334065A (cs) |
| SG (1) | SG66504A1 (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
| KR100452752B1 (ko) * | 2000-04-18 | 2004-10-12 | 주식회사 펩트론 | 단백질 함유 서방성 제제를 제조하는 방법 및 그 제제 |
| KR101705323B1 (ko) * | 2010-03-23 | 2017-02-13 | 코웨이 주식회사 | 역삼투막 방식의 정수기 |
| KR102176832B1 (ko) * | 2017-11-29 | 2020-11-10 | 주식회사 파이안바이오테크놀로지 | 헤지호그 단백질 및 생체 적합성 물질을 포함하는 미세 입자 및 이를 포함하는 탈모 예방 또는 치료용 조성물 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866165A (en) | 1997-01-15 | 1999-02-02 | Orquest, Inc. | Collagen-polysaccharide matrix for bone and cartilage repair |
-
1999
- 1999-01-28 CA CA002260423A patent/CA2260423C/en not_active Expired - Fee Related
- 1999-02-01 NO NO990471A patent/NO990471L/no unknown
- 1999-02-01 CZ CZ99337A patent/CZ33799A3/cs unknown
- 1999-02-01 MA MA25446A patent/MA26602A1/fr unknown
- 1999-02-02 IL IL12832999A patent/IL128329A/xx active IP Right Grant
- 1999-02-03 SG SG1999000333A patent/SG66504A1/en unknown
- 1999-02-03 HU HU9900251A patent/HUP9900251A3/hu unknown
- 1999-02-04 AT AT99101642T patent/ATE331533T1/de not_active IP Right Cessation
- 1999-02-04 KR KR1019990003759A patent/KR100311565B1/ko not_active Expired - Fee Related
- 1999-02-04 DE DE69932113T patent/DE69932113T2/de not_active Expired - Fee Related
- 1999-02-04 JP JP11027836A patent/JP3092706B2/ja not_active Expired - Fee Related
- 1999-02-04 AU AU15426/99A patent/AU713568B2/en not_active Ceased
- 1999-02-04 KR KR1019990003669A patent/KR19990072406A/ko not_active Ceased
- 1999-02-04 NZ NZ334065A patent/NZ334065A/en unknown
- 1999-02-04 CN CN99101764A patent/CN1228994A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69932113D1 (de) | 2006-08-10 |
| CN1228994A (zh) | 1999-09-22 |
| NO990471L (no) | 1999-08-05 |
| KR19990072423A (ko) | 1999-09-27 |
| IL128329A (en) | 2005-08-31 |
| KR19990072406A (ko) | 1999-09-27 |
| AU713568B2 (en) | 1999-12-02 |
| HUP9900251A3 (en) | 2001-01-29 |
| CZ33799A3 (cs) | 1999-08-11 |
| JP2000119193A (ja) | 2000-04-25 |
| DE69932113T2 (de) | 2007-01-25 |
| HU9900251D0 (en) | 1999-03-29 |
| KR100311565B1 (ko) | 2001-11-02 |
| AU1542699A (en) | 1999-08-26 |
| CA2260423A1 (en) | 1999-08-04 |
| NO990471D0 (no) | 1999-02-01 |
| CA2260423C (en) | 2006-06-20 |
| MA26602A1 (fr) | 2004-12-20 |
| ATE331533T1 (de) | 2006-07-15 |
| SG66504A1 (en) | 2000-07-18 |
| JP3092706B2 (ja) | 2000-09-25 |
| IL128329A0 (en) | 2000-01-31 |
| HUP9900251A2 (hu) | 1999-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |