NZ331446A - use of uridine triphosphates and related compounds to treat otitis media - Google Patents
use of uridine triphosphates and related compounds to treat otitis mediaInfo
- Publication number
- NZ331446A NZ331446A NZ331446A NZ33144697A NZ331446A NZ 331446 A NZ331446 A NZ 331446A NZ 331446 A NZ331446 A NZ 331446A NZ 33144697 A NZ33144697 A NZ 33144697A NZ 331446 A NZ331446 A NZ 331446A
- Authority
- NZ
- New Zealand
- Prior art keywords
- double bond
- formula
- otitis media
- adenine
- related compounds
- Prior art date
Links
- 206010033078 Otitis media Diseases 0.000 title abstract 2
- 235000011178 triphosphate Nutrition 0.000 title abstract 2
- 239000001226 triphosphate Substances 0.000 title abstract 2
- -1 uridine triphosphates Chemical class 0.000 title abstract 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title 1
- 229940045145 uridine Drugs 0.000 title 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 2
- 229930024421 Adenine Natural products 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- 229960000643 adenine Drugs 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 210000000959 ear middle Anatomy 0.000 abstract 2
- WWJWZQKUDYKLTK-UHFFFAOYSA-N 1,n6-ethenoadenine Chemical compound C1=NC2=NC=N[C]2C2=NC=CN21 WWJWZQKUDYKLTK-UHFFFAOYSA-N 0.000 abstract 1
- GICKXGZWALFYHZ-UHFFFAOYSA-N 3,N(4)-ethenocytosine Chemical compound O=C1NC=CC2=NC=CN12 GICKXGZWALFYHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Luminescent Compositions (AREA)
- Processing Of Solid Wastes (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/604,463 US6423694B1 (en) | 1996-02-21 | 1996-02-21 | Method of treating otitis media with uridine triphosphates and related compounds |
| PCT/US1997/002299 WO1997029756A1 (en) | 1996-02-21 | 1997-02-14 | Method of treating otitis media with uridine triphosphates and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ331446A true NZ331446A (en) | 2000-08-25 |
Family
ID=24419702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ331446A NZ331446A (en) | 1996-02-21 | 1997-02-14 | use of uridine triphosphates and related compounds to treat otitis media |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6423694B1 (enExample) |
| EP (1) | EP0897301B1 (enExample) |
| JP (1) | JP2000505447A (enExample) |
| KR (1) | KR19990082562A (enExample) |
| CN (1) | CN1211186A (enExample) |
| AT (1) | ATE225663T1 (enExample) |
| AU (1) | AU730888B2 (enExample) |
| CA (1) | CA2246581A1 (enExample) |
| DE (1) | DE69716255T2 (enExample) |
| NZ (1) | NZ331446A (enExample) |
| WO (1) | WO1997029756A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673779B2 (en) * | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
| NZ332426A (en) * | 1996-03-27 | 2000-09-29 | Univ North Carolina | Method of treating diseases involving dysfunction of ciliary movement such as ciliary dyskinesia and infertility with uridine triphosphates (UTP) and related compounds |
| US6420347B1 (en) | 1997-03-27 | 2002-07-16 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5968913A (en) * | 1996-07-03 | 1999-10-19 | Inspire Pharmaceuticals, Inc. | Pharmaceutical compositions of uridine triphosphate |
| DE19718826A1 (de) * | 1997-05-05 | 1998-11-12 | Marion S Dr Eckmiller | Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung |
| US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| NZ501696A (en) * | 1997-07-25 | 2001-08-31 | Inspire Pharmaceuticals Inc | Method for large-scale production of sodium and ammonium salts of di(uridine 5')-tetraphosphate |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| CN1151166C (zh) | 1998-10-02 | 2004-05-26 | 雅玛山酱油株式会社 | 二尿苷四磷酸或其盐的晶体和其制备方法、以及制备该化合物的方法 |
| CN100354296C (zh) * | 1998-10-02 | 2007-12-12 | 雅玛山酱油株式会社 | 二尿苷四磷酸或其盐的晶体和其制备方法、以及制备该化合物的方法 |
| US6645532B1 (en) * | 1999-01-19 | 2003-11-11 | Matthew Lutin | Compositions and method for relieving discomfort in the ears |
| US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| JP2005508297A (ja) | 2001-06-25 | 2005-03-31 | インスパイアー ファーマシューティカルズ，インコーポレイティド | Ｐ２ｙプリン受容体作用物質による関節潤滑 |
| AR037263A1 (es) | 2001-11-06 | 2004-11-03 | Inspire Pharmaceuticals Inc | Uso de una formulacion farmaceutica para la manufactura de un medicamento para el tratamiento o prevencion de enfermedades inflamatorias |
| CN1700894A (zh) * | 2002-10-18 | 2005-11-23 | 莫利化学医药公司 | 使用羊毛硫抗生素治疗干眼病的方法 |
| EP1753445A4 (en) * | 2004-05-06 | 2009-05-20 | Molichem Medicines Inc | TREATMENT OF EYE DISEASES AND EYE TREATMENTS WITH LANTIBIOTIC COMPOSITIONS |
| WO2005107787A1 (en) * | 2004-05-06 | 2005-11-17 | Molichem Medicines, Inc. | Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions |
| US7368439B2 (en) * | 2005-06-15 | 2008-05-06 | Bar - Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| US20070110788A1 (en) * | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
| AU2007221150B2 (en) | 2006-02-27 | 2012-09-20 | Ahm Technologies, Inc. | Eustachian tube device and method |
| US7959943B2 (en) * | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US7976873B2 (en) * | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US20070264296A1 (en) * | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
| US8088095B2 (en) * | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| US20090197956A1 (en) * | 2008-02-04 | 2009-08-06 | Arbor Pharmaceuticals, Inc. | Treatment of acute otitis media with xylitol and n-acetylcysteine |
| RU2513142C2 (ru) | 2008-06-12 | 2014-04-20 | Медтроник Ксомед Инк. | Способ лечения хронических ран |
| WO2010042427A2 (en) | 2008-10-06 | 2010-04-15 | Microbial Defense Systems, Llc | Antimicrobial composition and methods of making and using same |
| AU2012253476B2 (en) | 2011-05-10 | 2015-09-24 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
| HU227743B1 (en) * | 2011-07-22 | 2012-02-28 | Debreceni Egyetem | Eardrop composition and process for producing this |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260073A (en) * | 1990-05-21 | 1993-11-09 | Norwich Eaton Pharmaceuticals, Inc. | Use of phenylpropanolamine as a mucus secretogogue in the upper airways |
| GB9027968D0 (en) * | 1990-12-22 | 1991-02-13 | Fisons Plc | Method of treatment |
| EP0517573A1 (fr) * | 1991-06-05 | 1992-12-09 | Synthelabo | Compositions pharmaceutiques pour le traitement des affections des voies respiratoires |
| FR2677250B1 (fr) * | 1991-06-05 | 1995-01-20 | Synthelabo | Compositions pharmaceutiques contenant de l'adenosine-5-triphosphate disodique. |
| FR2684299B1 (fr) * | 1991-12-02 | 1995-03-24 | Synthelabo | Compositions pharmaceutiques contenant de l'adenosine-5-triphosphate disodique et de l'amiloride. |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US5789391A (en) * | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
-
1996
- 1996-02-21 US US08/604,463 patent/US6423694B1/en not_active Expired - Fee Related
-
1997
- 1997-02-14 WO PCT/US1997/002299 patent/WO1997029756A1/en not_active Ceased
- 1997-02-14 KR KR1019980706300A patent/KR19990082562A/ko not_active Withdrawn
- 1997-02-14 EP EP97905953A patent/EP0897301B1/en not_active Expired - Lifetime
- 1997-02-14 AU AU22724/97A patent/AU730888B2/en not_active Ceased
- 1997-02-14 DE DE69716255T patent/DE69716255T2/de not_active Expired - Fee Related
- 1997-02-14 CA CA002246581A patent/CA2246581A1/en not_active Abandoned
- 1997-02-14 CN CN97192262A patent/CN1211186A/zh active Pending
- 1997-02-14 JP JP9529493A patent/JP2000505447A/ja not_active Ceased
- 1997-02-14 AT AT97905953T patent/ATE225663T1/de not_active IP Right Cessation
- 1997-02-14 NZ NZ331446A patent/NZ331446A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1211186A (zh) | 1999-03-17 |
| DE69716255T2 (de) | 2003-07-03 |
| US6423694B1 (en) | 2002-07-23 |
| AU730888B2 (en) | 2001-03-15 |
| WO1997029756A1 (en) | 1997-08-21 |
| AU2272497A (en) | 1997-09-02 |
| JP2000505447A (ja) | 2000-05-09 |
| ATE225663T1 (de) | 2002-10-15 |
| CA2246581A1 (en) | 1997-08-21 |
| EP0897301A1 (en) | 1999-02-24 |
| DE69716255D1 (de) | 2002-11-14 |
| EP0897301B1 (en) | 2002-10-09 |
| KR19990082562A (ko) | 1999-11-25 |
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