NZ247488A - 2-aryl-2-hydroxy-3-azolylpropylazolone derivatives; their use as anti-fungal agents - Google Patents

2-aryl-2-hydroxy-3-azolylpropylazolone derivatives; their use as anti-fungal agents

Info

Publication number
NZ247488A
NZ247488A NZ247488A NZ24748893A NZ247488A NZ 247488 A NZ247488 A NZ 247488A NZ 247488 A NZ247488 A NZ 247488A NZ 24748893 A NZ24748893 A NZ 24748893A NZ 247488 A NZ247488 A NZ 247488A
Authority
NZ
New Zealand
Prior art keywords
compound
salt
difluorophenyl
phenyl
group
Prior art date
Application number
NZ247488A
Other languages
English (en)
Inventor
Katsumi Itoh
Kenji Okonogi
Norikazu Tamura
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NZ247488A publication Critical patent/NZ247488A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
NZ247488A 1992-04-28 1993-04-26 2-aryl-2-hydroxy-3-azolylpropylazolone derivatives; their use as anti-fungal agents NZ247488A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11040092 1992-04-28
JP2262393 1993-02-10

Publications (1)

Publication Number Publication Date
NZ247488A true NZ247488A (en) 1995-02-24

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ247488A NZ247488A (en) 1992-04-28 1993-04-26 2-aryl-2-hydroxy-3-azolylpropylazolone derivatives; their use as anti-fungal agents

Country Status (18)

Country Link
US (2) US5371101A (cg-RX-API-DMAC10.html)
EP (1) EP0567982B1 (cg-RX-API-DMAC10.html)
JP (1) JP2818097B2 (cg-RX-API-DMAC10.html)
KR (1) KR100257619B1 (cg-RX-API-DMAC10.html)
CN (1) CN1040433C (cg-RX-API-DMAC10.html)
AT (1) ATE167857T1 (cg-RX-API-DMAC10.html)
AU (1) AU655544B2 (cg-RX-API-DMAC10.html)
CA (1) CA2094962A1 (cg-RX-API-DMAC10.html)
DE (1) DE69319380T2 (cg-RX-API-DMAC10.html)
DK (1) DK0567982T3 (cg-RX-API-DMAC10.html)
ES (1) ES2118160T3 (cg-RX-API-DMAC10.html)
FI (1) FI931901A7 (cg-RX-API-DMAC10.html)
HU (2) HUT64327A (cg-RX-API-DMAC10.html)
NO (1) NO303284B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ247488A (cg-RX-API-DMAC10.html)
PH (1) PH31082A (cg-RX-API-DMAC10.html)
SG (1) SG48939A1 (cg-RX-API-DMAC10.html)
TW (1) TW218017B (cg-RX-API-DMAC10.html)

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HU212458B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
TW297813B (cg-RX-API-DMAC10.html) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
EP0746318A1 (en) * 1994-02-25 1996-12-11 Takeda Chemical Industries, Ltd. Injectable emulsions containing antifungal triazole derivatives
CA2150533A1 (en) * 1994-05-31 1995-12-01 Katsumi Itoh Production of optically active triazole compounds and their intermediates
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
CA2211458A1 (en) * 1995-02-17 1996-08-22 Kenji Okonogi Azole compounds, their production and use
TW318841B (cg-RX-API-DMAC10.html) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
US5807854A (en) * 1995-08-02 1998-09-15 J. Uriah & Cia. S.A. Pyrimidone derivatives with antifungal activity
KR970705560A (ko) * 1995-08-02 1997-10-09 호아껭 우리아치 토렐로 항진균 활성을 갖는 신규한 카르복사미드(new carboxamides with antifungal activity)
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
WO1998039305A1 (en) * 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound
AU6520098A (en) * 1997-03-31 1998-10-22 Takeda Chemical Industries Ltd. Azole compounds, their production and their use
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
CA2345612A1 (en) 1998-09-29 2000-04-06 Masao Nagao Anti-fungal composition
IN191188B (cg-RX-API-DMAC10.html) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
CA2402345A1 (en) * 2000-03-07 2001-09-13 Sudershan K. Arora Azole compounds as therapeutic agents for fungal infections
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
SK9522003A3 (en) * 2000-12-26 2003-12-02 Ranbaxy Lab Ltd Azole compounds as anti-fungals agents
HRP20030854B1 (en) * 2001-03-23 2011-11-30 Richter Gedeon Vegyesz�ti Gy�r RT Process for preparing fluconazole and its crystal modifications
IN191819B (cg-RX-API-DMAC10.html) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (cg-RX-API-DMAC10.html) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
AU2002253440A1 (en) * 2002-04-12 2003-10-27 Ranbaxy Laboratories Limited Derivatives of 2,2,4-trisubstituted tetrahydrofuran as antifungal agents
AU2003242238A1 (en) * 2002-06-18 2003-12-31 Pola Chemical Industries Inc. Antifungal medicinal compositions
AU2002328176A1 (en) * 2002-08-26 2004-03-11 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
EP1817295B1 (en) 2004-11-18 2012-11-07 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
JP5178515B2 (ja) * 2005-08-12 2013-04-10 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するピラゾール化合物
CA2618628C (en) * 2005-08-18 2014-11-18 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
ES2484042T3 (es) 2006-05-25 2014-08-08 Synta Pharmaceuticals Corporation Compuestos de triazol que modulan la actividad de HSP90
WO2007139960A2 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Compounds that modulate hsp90 activity and methods for identifying same
CA2653222A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
JP5410965B2 (ja) * 2006-05-25 2014-02-05 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
KR20090053903A (ko) 2006-08-07 2009-05-28 스티펠 래버러토리즈, 인코포레이티드(어 델라웨어 코포레이션) 결정성 항진균 화합물
KR101118410B1 (ko) * 2006-10-19 2012-04-23 에프. 호프만-라 로슈 아게 당뇨병을 위한 11베타-에이치에스디1 억제제로서의 이미다졸론 및 이미다졸리딘온 유도체
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
EP2773345A1 (en) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
CA2854188A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors

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GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
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DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
HUT64327A (en) 1993-12-28
NO931533L (no) 1993-10-29
DE69319380T2 (de) 1998-10-29
ATE167857T1 (de) 1998-07-15
PH31082A (en) 1998-02-05
FI931901L (fi) 1993-10-29
CA2094962A1 (en) 1993-10-29
KR100257619B1 (en) 2000-07-01
CN1040433C (zh) 1998-10-28
AU655544B2 (en) 1994-12-22
JPH06293740A (ja) 1994-10-21
EP0567982A1 (en) 1993-11-03
KR940005616A (ko) 1994-03-21
FI931901A7 (fi) 1993-10-29
HU9301226D0 (en) 1993-07-28
AU3822193A (en) 1993-11-04
DE69319380D1 (de) 1998-08-06
FI931901A0 (fi) 1993-04-27
NO303284B1 (no) 1998-06-22
HU211474A9 (en) 1995-11-28
US5466820A (en) 1995-11-14
CN1079467A (zh) 1993-12-15
DK0567982T3 (da) 1999-04-12
ES2118160T3 (es) 1998-09-16
TW218017B (cg-RX-API-DMAC10.html) 1993-12-21
NO931533D0 (no) 1993-04-27
JP2818097B2 (ja) 1998-10-30
SG48939A1 (en) 1998-05-18
EP0567982B1 (en) 1998-07-01
US5371101A (en) 1994-12-06

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