NZ223198A - Dna sequence for expression in an e. coli host of a polypeptide with the properties of human basic fibroblast growth factor and its use in the production of this protein - Google Patents
Dna sequence for expression in an e. coli host of a polypeptide with the properties of human basic fibroblast growth factor and its use in the production of this proteinInfo
- Publication number
- NZ223198A NZ223198A NZ22319888A NZ22319888A NZ223198A NZ 223198 A NZ223198 A NZ 223198A NZ 22319888 A NZ22319888 A NZ 22319888A NZ 22319888 A NZ22319888 A NZ 22319888A NZ 223198 A NZ223198 A NZ 223198A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dna
- growth factor
- fibroblast growth
- dna sequence
- basic fibroblast
- Prior art date
Links
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- RZCIEJXAILMSQK-JXOAFFINSA-N TTP Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 RZCIEJXAILMSQK-JXOAFFINSA-N 0.000 description 1
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- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
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- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
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- 239000013613 expression plasmid Substances 0.000 description 1
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- 108700004203 eye-derived growth factor Proteins 0.000 description 1
- 239000012527 feed solution Substances 0.000 description 1
- 229940029303 fibroblast growth factor-1 Drugs 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 102000035122 glycosylated proteins Human genes 0.000 description 1
- 108091005608 glycosylated proteins Proteins 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 108010052188 hepatoma-derived growth factor Proteins 0.000 description 1
- 108010063968 hypothalamus-derived growth factor Proteins 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
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- 239000004325 lysozyme Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
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- 230000000813 microbial effect Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
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- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229910021654 trace metal Inorganic materials 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- XREXPQGDOPQPAH-QKUPJAQQSA-K trisodium;[(z)-18-[1,3-bis[[(z)-12-sulfonatooxyoctadec-9-enoyl]oxy]propan-2-yloxy]-18-oxooctadec-9-en-7-yl] sulfate Chemical compound [Na+].[Na+].[Na+].CCCCCCC(OS([O-])(=O)=O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O)COC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O XREXPQGDOPQPAH-QKUPJAQQSA-K 0.000 description 1
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- NLIVDORGVGAOOJ-MAHBNPEESA-M xylene cyanol Chemical compound [Na+].C1=C(C)C(NCC)=CC=C1C(\C=1C(=CC(OS([O-])=O)=CC=1)OS([O-])=O)=C\1C=C(C)\C(=[NH+]/CC)\C=C/1 NLIVDORGVGAOOJ-MAHBNPEESA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US437987A | 1987-01-16 | 1987-01-16 | |
| US11643087A | 1987-11-03 | 1987-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ223198A true NZ223198A (en) | 1991-06-25 |
Family
ID=26672920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ22319888A NZ223198A (en) | 1987-01-16 | 1988-01-14 | Dna sequence for expression in an e. coli host of a polypeptide with the properties of human basic fibroblast growth factor and its use in the production of this protein |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0275204A3 (de) |
| JP (1) | JPH01501840A (de) |
| AU (1) | AU1185488A (de) |
| CA (1) | CA1323317C (de) |
| DK (1) | DK510388A (de) |
| FI (1) | FI884252A0 (de) |
| NZ (1) | NZ223198A (de) |
| PT (1) | PT86558B (de) |
| WO (1) | WO1988005465A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026839A (en) * | 1985-12-17 | 1991-06-25 | Synergen, Inc | DNA encoding a basic fibroblast growth factor |
| US4994559A (en) * | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
| US5852177A (en) * | 1987-02-24 | 1998-12-22 | Takeda Chemical Industries, Ltd. | Basic fibroblast growth factor (bFGF) muteins |
| EP0326907A1 (de) * | 1988-01-26 | 1989-08-09 | Takeda Chemical Industries, Ltd. | Polypeptide, DNA und ihre Verwendung |
| US5175147A (en) * | 1988-08-19 | 1992-12-29 | Takeda Chemical Industries, Ltd | Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract |
| US5352589A (en) * | 1988-09-16 | 1994-10-04 | Farmitalia Carlo Erba S.R.L. | Deletion mutant of basic fibroblast growth factor and production thereof |
| GB8821795D0 (en) * | 1988-09-16 | 1988-10-19 | Erba Carlo Spa | New derivatives of human/bovine basic fibroplast growth factor |
| US5656458A (en) * | 1988-11-04 | 1997-08-12 | Chiron Corporation | Expression and processing of amino terminus acetylated FGF's in yeast |
| DE68927009T2 (de) * | 1988-11-04 | 1997-04-03 | Chiron Corp | EXPRESSION UND PROZESSIERUNG VON ACETYLIERTEN FGFs IN HEFEN |
| US5464943A (en) * | 1989-04-26 | 1995-11-07 | Takeda Chemical Industries, Ltd. | DNA encoding glycosylated FGF and production thereof |
| US5126323A (en) * | 1989-11-16 | 1992-06-30 | Genetics Institute, Inc. | Homogeneous purified k-fgf and compositions containing the same |
| US5143829A (en) * | 1990-03-29 | 1992-09-01 | California Biotechnology Inc. | High level expression of basic fibroblast growth factor having a homogeneous n-terminus |
| US5136025A (en) * | 1990-04-04 | 1992-08-04 | California Biotechnology Inc. | Method to purify basic fibroblast growth factor |
| JPH047617A (ja) * | 1990-04-26 | 1992-01-13 | Canon Inc | 電子機器 |
| JPH04178328A (ja) * | 1990-11-08 | 1992-06-25 | Unitika Ltd | 血管新生阻害剤 |
| US5206354A (en) * | 1990-11-23 | 1993-04-27 | American Cyanamid Company | Dna sequence encoding active fragment of fibroblast growth factor, hbf-2 |
| WO1992013958A1 (en) * | 1991-02-06 | 1992-08-20 | Georgetown University | Receptor blocking peptides of fibroblast growth factor receptor |
| US5492894A (en) * | 1991-03-21 | 1996-02-20 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
| US5461029A (en) * | 1992-04-24 | 1995-10-24 | American Cyanamid Company | Method of treating herpes viral infections using HBNF and MK proteins |
| JP5704780B2 (ja) | 1999-08-13 | 2015-04-22 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 脈管形成因子の用量および心筋血流を改善するための投与方法 |
| JP6548293B2 (ja) * | 2015-09-30 | 2019-07-24 | 片山化学工業株式会社 | ｂＦＧＦの精製方法およびｂＦＧＦの製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4956455A (en) * | 1984-03-05 | 1990-09-11 | The Salk Institute For Biological Studies | Bovine fibroblast growth factor |
| ATE222602T1 (de) * | 1985-09-12 | 2002-09-15 | Scios Inc | Rekombinante fibroblasten-wachstums-faktoren |
| IL81839A0 (en) * | 1986-03-14 | 1987-10-20 | Takeda Chemical Industries Ltd | Polypeptide,dna and its use |
-
1988
- 1988-01-13 AU AU11854/88A patent/AU1185488A/en not_active Abandoned
- 1988-01-13 WO PCT/US1988/000068 patent/WO1988005465A1/en active Application Filing
- 1988-01-13 CA CA 556440 patent/CA1323317C/en not_active Expired - Fee Related
- 1988-01-13 JP JP88501259A patent/JPH01501840A/ja active Pending
- 1988-01-14 EP EP88300303A patent/EP0275204A3/de not_active Withdrawn
- 1988-01-14 NZ NZ22319888A patent/NZ223198A/en unknown
- 1988-01-15 PT PT8655888A patent/PT86558B/pt active IP Right Grant
- 1988-09-14 DK DK510388A patent/DK510388A/da not_active Application Discontinuation
- 1988-09-15 FI FI884252A patent/FI884252A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01501840A (ja) | 1989-06-29 |
| AU1185488A (en) | 1988-08-10 |
| PT86558B (pt) | 1992-07-31 |
| FI884252A (fi) | 1988-09-15 |
| DK510388A (da) | 1988-11-11 |
| DK510388D0 (da) | 1988-09-14 |
| PT86558A (en) | 1988-02-01 |
| WO1988005465A1 (en) | 1988-07-28 |
| CA1323317C (en) | 1993-10-19 |
| EP0275204A3 (de) | 1990-05-02 |
| EP0275204A2 (de) | 1988-07-20 |
| FI884252A0 (fi) | 1988-09-15 |
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