NZ219380A - (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions - Google Patents

(n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions

Info

Publication number
NZ219380A
NZ219380A NZ219380A NZ21938087A NZ219380A NZ 219380 A NZ219380 A NZ 219380A NZ 219380 A NZ219380 A NZ 219380A NZ 21938087 A NZ21938087 A NZ 21938087A NZ 219380 A NZ219380 A NZ 219380A
Authority
NZ
New Zealand
Prior art keywords
piperazinyl
piperidinyl
methylazole
derivatives
pharmaceutical compositions
Prior art date
Application number
NZ219380A
Other languages
English (en)
Inventor
Wijngaarden Ineke Van
Cornelis Gerrit Kruse
Der Heyden Johannes Antoni Van
Theodorus Maria Tulp
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of NZ219380A publication Critical patent/NZ219380A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
NZ219380A 1986-02-27 1987-02-24 (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions NZ219380A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8600488 1986-02-27

Publications (1)

Publication Number Publication Date
NZ219380A true NZ219380A (en) 1990-06-26

Family

ID=19847632

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ219380A NZ219380A (en) 1986-02-27 1987-02-24 (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions

Country Status (15)

Country Link
US (2) US4772604A (show.php)
EP (1) EP0241053B1 (show.php)
JP (1) JPH0798800B2 (show.php)
AT (1) ATE82281T1 (show.php)
AU (1) AU585131B2 (show.php)
CA (1) CA1279645C (show.php)
DE (1) DE3782525T2 (show.php)
DK (1) DK93087A (show.php)
ES (1) ES2052545T3 (show.php)
GR (1) GR3006689T3 (show.php)
IE (1) IE61724B1 (show.php)
IL (1) IL81669A (show.php)
NZ (1) NZ219380A (show.php)
PH (1) PH22783A (show.php)
ZA (1) ZA871335B (show.php)

Families Citing this family (46)

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DK93087A (da) * 1986-02-27 1987-08-28 Duphar Int Res Hidtil ukendte aryl substituerede (n-piperidinyl)methyl- og (n-piperazinyl)methylazoler med antipsykotiske egenskaber
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
GB9021453D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
US5569659A (en) * 1991-09-11 1996-10-29 Mcneilab, Inc. 4-arylpiperazines and 4-arylpiperidines
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
ATE171162T1 (de) * 1992-08-06 1998-10-15 Smithkline Beecham Plc 5-(2-oxyphenyl)-pyrrol-derivate als dopamin-d3- rezeptor-antagonisten
US5314885A (en) * 1992-09-11 1994-05-24 Mcneilab, Inc. Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
GB9307400D0 (en) * 1993-04-08 1993-06-02 Smithkline Beecham Plc Compounds
JPH08511789A (ja) * 1993-06-25 1996-12-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー フェニルピロール誘導体およびドーパミンｄ３拮抗薬としてのそれらの使用
GB9315801D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9315800D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9320855D0 (en) * 1993-10-09 1993-12-01 Smithkline Beecham Plc Compounds
GB9325827D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Plc Compounds
GB9402197D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Compounds
GB9403199D0 (en) * 1994-02-19 1994-04-13 Smithkline Beecham Plc Compounds
WO1996016057A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
GB9512129D0 (en) * 1995-06-15 1995-08-16 Smithkline Beecham Plc Compounds
WO1997003067A1 (en) * 1995-07-13 1997-01-30 Knoll Aktiengesellschaft Piperazine derivatives as therapeutic agents
PT889889E (pt) * 1996-03-29 2007-01-31 Duphar Int Res Composto de piperazina e piperidina
CA2275796A1 (en) 1996-12-23 1998-07-02 Donald Joseph Phillip Pinto Nitrogen containing heteroaromatics as factor xa inhibitors
CA2278677A1 (en) * 1997-01-27 1998-07-30 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
TW530054B (en) * 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
CN1294124C (zh) 2000-07-04 2007-01-10 协友株式会社 苯并噁唑化合物、其生产方法和除草剂
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
AU2005219438B2 (en) * 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
BRPI0405418A (pt) * 2004-09-02 2006-05-02 Univ Rio De Janeiro uso de derivados n-fenilperazìnicos e composições farmacêuticas contendo os mesmos
TW200800946A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Substituted piperazines as metabotropic glutamate receptor antagonists
KR100654328B1 (ko) 2005-08-26 2006-12-08 한국과학기술연구원 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
CN103570705B (zh) * 2012-07-18 2017-01-25 中国医学科学院医药生物技术研究所 取代的n‑((1＇,3＇‑杂唑‑4＇‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途
KR20160098506A (ko) * 2013-12-20 2016-08-18 라보라토리오스 델 드라. 에스테브.에스.에이. 통증에 대한 다양한 활성을 갖는 피페라진 유도체
CN105829297B (zh) * 2013-12-20 2019-08-09 埃斯蒂文制药股份有限公司 具有抗疼痛的多重模式活性的哌啶化合物

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US3407199A (en) * 1966-01-18 1968-10-22 Endo Lab Tertiaryamino ethyl or propyl pyrrol-2-yl ketones
DE2261351A1 (de) * 1972-12-15 1974-06-20 Merck Patent Gmbh Pyrazolderivate und verfahren zu ihrer herstellung
DE2526469A1 (de) * 1975-06-13 1976-12-30 Bayer Ag 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4032526A (en) * 1975-10-02 1977-06-28 American Cyanamid Company 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts
US4123529A (en) * 1976-04-23 1978-10-31 Lilly Industries Limited Phenylpiperazine derivatives
DE2747531A1 (de) * 1977-10-22 1979-04-26 Basf Ag Substituierte 3-aminopyrazole
FR2537133A1 (fr) * 1982-12-07 1984-06-08 Rhone Poulenc Sante Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent
ZA848005B (en) * 1983-10-17 1985-05-29 Duphar Int Res Blood-pressure lowering piperazine derivatives
US4562189A (en) * 1984-10-09 1985-12-31 American Cyanamid Company Pyrazolylpiperazines
DE3442860A1 (de) * 1984-11-24 1986-05-28 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK93087A (da) * 1986-02-27 1987-08-28 Duphar Int Res Hidtil ukendte aryl substituerede (n-piperidinyl)methyl- og (n-piperazinyl)methylazoler med antipsykotiske egenskaber

Also Published As

Publication number Publication date
JPH0798800B2 (ja) 1995-10-25
ZA871335B (en) 1987-09-30
US4874770A (en) 1989-10-17
PH22783A (en) 1988-12-12
US4772604A (en) 1988-09-20
ATE82281T1 (de) 1992-11-15
IL81669A (en) 1990-11-29
IL81669A0 (en) 1987-09-16
ES2052545T3 (es) 1994-07-16
DK93087A (da) 1987-08-28
EP0241053B1 (en) 1992-11-11
DE3782525D1 (de) 1992-12-17
IE61724B1 (en) 1994-11-30
JPS62205058A (ja) 1987-09-09
AU6924787A (en) 1987-09-03
EP0241053A1 (en) 1987-10-14
GR3006689T3 (show.php) 1993-06-30
AU585131B2 (en) 1989-06-08
CA1279645C (en) 1991-01-29
IE870466L (en) 1987-08-27
DK93087D0 (da) 1987-02-24
DE3782525T2 (de) 1993-05-27

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