DE3782525D1 - Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung. - Google Patents
Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung.Info
- Publication number
- DE3782525D1 DE3782525D1 DE8787200296T DE3782525T DE3782525D1 DE 3782525 D1 DE3782525 D1 DE 3782525D1 DE 8787200296 T DE8787200296 T DE 8787200296T DE 3782525 T DE3782525 T DE 3782525T DE 3782525 D1 DE3782525 D1 DE 3782525D1
- Authority
- DE
- Germany
- Prior art keywords
- piperazinyl
- piperidinyl
- substituted
- methyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8600488 | 1986-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3782525D1 true DE3782525D1 (de) | 1992-12-17 |
DE3782525T2 DE3782525T2 (de) | 1993-05-27 |
Family
ID=19847632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787200296T Expired - Fee Related DE3782525T2 (de) | 1986-02-27 | 1987-02-24 | Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung. |
Country Status (15)
Country | Link |
---|---|
US (2) | US4772604A (de) |
EP (1) | EP0241053B1 (de) |
JP (1) | JPH0798800B2 (de) |
AT (1) | ATE82281T1 (de) |
AU (1) | AU585131B2 (de) |
CA (1) | CA1279645C (de) |
DE (1) | DE3782525T2 (de) |
DK (1) | DK93087A (de) |
ES (1) | ES2052545T3 (de) |
GR (1) | GR3006689T3 (de) |
IE (1) | IE61724B1 (de) |
IL (1) | IL81669A (de) |
NZ (1) | NZ219380A (de) |
PH (1) | PH22783A (de) |
ZA (1) | ZA871335B (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1279645C (en) * | 1986-02-27 | 1991-01-29 | Ineke Van Wijngaarden | Aryl-substituted (n-piperidinyl)methyl- and (n-piperazinyl)methylazoles having antipsychotic properties |
US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
US5159083A (en) * | 1990-12-28 | 1992-10-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
US5569659A (en) * | 1991-09-11 | 1996-10-29 | Mcneilab, Inc. | 4-arylpiperazines and 4-arylpiperidines |
IE914218A1 (en) * | 1991-09-11 | 1993-03-24 | Mcneilab Inc | Novel 4-arylpiperazines and 4-arylpiperidines |
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
NZ254784A (en) * | 1992-08-06 | 1996-11-26 | Smithkline Beecham Plc | Substituted 5-phenyl pyrrole derivatives and medicaments |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
GB9306578D0 (en) * | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
GB9307400D0 (en) * | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
EP0705259B1 (de) * | 1993-06-25 | 1998-02-25 | Smithkline Beecham Plc | Phenylpyrrol-derivate und ihre verwendung als dopamin d3 antagonisten |
GB9315801D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9315800D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9320855D0 (en) * | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
GB9403199D0 (en) * | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
WO1996016057A1 (en) * | 1994-11-23 | 1996-05-30 | Neurogen Corporation | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands |
US5478934A (en) * | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
GB9512129D0 (en) * | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
AU6517196A (en) * | 1995-07-13 | 1997-02-10 | Knoll Aktiengesellschaft | Piperazine derivatives as therapeutic agents |
CA2250347C (en) | 1996-03-29 | 2006-02-21 | Duphar International Research B.V. | Piperazine and piperidine compounds with high affinity for dopamine-d2 and serotonin-5ht1a receptors |
IL130286A0 (en) | 1996-12-23 | 2000-06-01 | Du Pont Pharm Co | Nitrogen containing heteroaromatics as factor Xa inhibitors |
EA002101B1 (ru) * | 1997-01-27 | 2001-12-24 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
TW530054B (en) * | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
BR0112373A (pt) | 2000-07-04 | 2003-09-09 | Ube Industries | Compostos de benzoxazol, processo para a produção dos mesmos e herbicidas |
JP5080716B2 (ja) | 2001-07-20 | 2012-11-21 | サイコジェニックス・インコーポレーテッド | 注意欠陥・多動性障害の治療 |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
CN1867336B (zh) | 2002-06-12 | 2010-05-12 | 凯莫森特里克斯股份有限公司 | 1-芳基-4-取代的哌嗪衍生物及其制药用途 |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
EP1720545B1 (de) * | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bizyklische und überbrückte stickstoff-heterozyklen |
BRPI0405418A (pt) * | 2004-09-02 | 2006-05-02 | Univ Rio De Janeiro | uso de derivados n-fenilperazìnicos e composições farmacêuticas contendo os mesmos |
TW200800946A (en) * | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Substituted piperazines as metabotropic glutamate receptor antagonists |
KR100654328B1 (ko) | 2005-08-26 | 2006-12-08 | 한국과학기술연구원 | 피페라지닐알킬피라졸계 t-타입 칼슘 채널 억제 화합물 및이의 제조방법 |
US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
CN103570705B (zh) * | 2012-07-18 | 2017-01-25 | 中国医学科学院医药生物技术研究所 | 取代的n‑((1',3'‑杂唑‑4'‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途 |
CA2932051A1 (en) | 2013-12-20 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Piperazine derivatives having multimodal activity against pain |
EP3083595B1 (de) * | 2013-12-20 | 2020-05-27 | Esteve Pharmaceuticals, S.A. | Piperidinverbindungen mit multimodaler aktivität gegen schmerzen |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3407199A (en) * | 1966-01-18 | 1968-10-22 | Endo Lab | Tertiaryamino ethyl or propyl pyrrol-2-yl ketones |
DE2261351A1 (de) * | 1972-12-15 | 1974-06-20 | Merck Patent Gmbh | Pyrazolderivate und verfahren zu ihrer herstellung |
DE2526469A1 (de) * | 1975-06-13 | 1976-12-30 | Bayer Ag | 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4032526A (en) * | 1975-10-02 | 1977-06-28 | American Cyanamid Company | 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts |
US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
DE2747531A1 (de) * | 1977-10-22 | 1979-04-26 | Basf Ag | Substituierte 3-aminopyrazole |
FR2537133A1 (fr) * | 1982-12-07 | 1984-06-08 | Rhone Poulenc Sante | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
DK169601B1 (da) * | 1983-10-17 | 1994-12-19 | Duphar Int Res | Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse |
US4562189A (en) * | 1984-10-09 | 1985-12-31 | American Cyanamid Company | Pyrazolylpiperazines |
DE3442860A1 (de) * | 1984-11-24 | 1986-05-28 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
CA1279645C (en) * | 1986-02-27 | 1991-01-29 | Ineke Van Wijngaarden | Aryl-substituted (n-piperidinyl)methyl- and (n-piperazinyl)methylazoles having antipsychotic properties |
-
1987
- 1987-02-24 CA CA000530424A patent/CA1279645C/en not_active Expired - Lifetime
- 1987-02-24 AT AT87200296T patent/ATE82281T1/de not_active IP Right Cessation
- 1987-02-24 PH PH34901A patent/PH22783A/en unknown
- 1987-02-24 US US07/018,164 patent/US4772604A/en not_active Expired - Lifetime
- 1987-02-24 DE DE8787200296T patent/DE3782525T2/de not_active Expired - Fee Related
- 1987-02-24 ES ES87200296T patent/ES2052545T3/es not_active Expired - Lifetime
- 1987-02-24 EP EP87200296A patent/EP0241053B1/de not_active Expired - Lifetime
- 1987-02-24 IE IE46687A patent/IE61724B1/en not_active IP Right Cessation
- 1987-02-24 NZ NZ219380A patent/NZ219380A/xx unknown
- 1987-02-24 IL IL81669A patent/IL81669A/xx not_active IP Right Cessation
- 1987-02-24 DK DK093087A patent/DK93087A/da not_active Application Discontinuation
- 1987-02-24 ZA ZA871335A patent/ZA871335B/xx unknown
- 1987-02-25 AU AU69247/87A patent/AU585131B2/en not_active Ceased
- 1987-02-25 JP JP62040530A patent/JPH0798800B2/ja not_active Expired - Lifetime
-
1988
- 1988-07-01 US US07/214,310 patent/US4874770A/en not_active Expired - Lifetime
-
1992
- 1992-12-28 GR GR920403153T patent/GR3006689T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU6924787A (en) | 1987-09-03 |
DE3782525T2 (de) | 1993-05-27 |
PH22783A (en) | 1988-12-12 |
IL81669A (en) | 1990-11-29 |
CA1279645C (en) | 1991-01-29 |
NZ219380A (en) | 1990-06-26 |
DK93087D0 (da) | 1987-02-24 |
US4772604A (en) | 1988-09-20 |
ES2052545T3 (es) | 1994-07-16 |
ZA871335B (en) | 1987-09-30 |
ATE82281T1 (de) | 1992-11-15 |
GR3006689T3 (de) | 1993-06-30 |
JPH0798800B2 (ja) | 1995-10-25 |
IE61724B1 (en) | 1994-11-30 |
IL81669A0 (en) | 1987-09-16 |
EP0241053B1 (de) | 1992-11-11 |
EP0241053A1 (de) | 1987-10-14 |
US4874770A (en) | 1989-10-17 |
AU585131B2 (en) | 1989-06-08 |
DK93087A (da) | 1987-08-28 |
JPS62205058A (ja) | 1987-09-09 |
IE870466L (en) | 1987-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |