IT8705102A0 - Derivati di prolina. - Google Patents

Derivati di prolina.

Info

Publication number
IT8705102A0
IT8705102A0 IT8705102A IT510287A IT8705102A0 IT 8705102 A0 IT8705102 A0 IT 8705102A0 IT 8705102 A IT8705102 A IT 8705102A IT 510287 A IT510287 A IT 510287A IT 8705102 A0 IT8705102 A0 IT 8705102A0
Authority
IT
Italy
Prior art keywords
proline derivatives
proline
derivatives
Prior art date
Application number
IT8705102A
Other languages
English (en)
Other versions
IT1216999B (it
Inventor
Shizuo Nakamura
Masatoschi Inai
Makoto Inoue
Kazushi Nagao
Yoshiaki Tsuda
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IT8705102A0 publication Critical patent/IT8705102A0/it
Application granted granted Critical
Publication of IT1216999B publication Critical patent/IT1216999B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
IT8705102A 1986-01-17 1987-01-13 Derivati di prolina. IT1216999B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP863486 1986-01-17
JP8579786 1986-04-14
JP61293782A JPH0662671B2 (ja) 1986-01-17 1986-12-09 プロリン誘導体

Publications (2)

Publication Number Publication Date
IT8705102A0 true IT8705102A0 (it) 1987-01-13
IT1216999B IT1216999B (it) 1990-03-14

Family

ID=27278113

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8705102A IT1216999B (it) 1986-01-17 1987-01-13 Derivati di prolina.

Country Status (7)

Country Link
US (1) US4977179A (it)
JP (1) JPH0662671B2 (it)
CH (1) CH671016A5 (it)
DE (1) DE3701209A1 (it)
FR (1) FR2595704B1 (it)
GB (1) GB2186578B (it)
IT (1) IT1216999B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0657707B2 (ja) * 1987-05-25 1994-08-03 吉富製薬株式会社 ピペリジン化合物
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
EP0674532B1 (en) * 1992-12-17 2003-05-28 Advanced Medical Optics, Inc. Contact lens disinfecting solution containing an oxidizing agent and polyvinyl pyrrolidone
US5319098A (en) * 1993-05-18 1994-06-07 Celgene Corporation Process for the stereoselective preparation of L-alanyl-L-proline

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4661515A (en) * 1982-07-21 1987-04-28 Usv Pharmaceutical Corporation Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
US4642355A (en) * 1984-02-24 1987-02-10 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
US4886813A (en) * 1985-11-13 1989-12-12 Otsuka Pharmaceutical Factory, Inc. Proline derivatives

Also Published As

Publication number Publication date
US4977179A (en) 1990-12-11
DE3701209A1 (de) 1987-07-23
GB8700115D0 (en) 1987-02-11
IT1216999B (it) 1990-03-14
GB2186578A (en) 1987-08-19
FR2595704A1 (fr) 1987-09-18
GB2186578B (en) 1990-07-11
CH671016A5 (it) 1989-07-31
JPH0662671B2 (ja) 1994-08-17
JPS63115897A (ja) 1988-05-20
DE3701209C2 (it) 1990-12-20
FR2595704B1 (fr) 1993-08-13

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