GR3006689T3 - - Google Patents
Info
- Publication number
- GR3006689T3 GR3006689T3 GR920403153T GR920403153T GR3006689T3 GR 3006689 T3 GR3006689 T3 GR 3006689T3 GR 920403153 T GR920403153 T GR 920403153T GR 920403153 T GR920403153 T GR 920403153T GR 3006689 T3 GR3006689 T3 GR 3006689T3
- Authority
- GR
- Greece
- Prior art keywords
- compounds
- methylazoes
- antipsychotic
- piperazinyl
- piperidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8600488 | 1986-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3006689T3 true GR3006689T3 (el) | 1993-06-30 |
Family
ID=19847632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR920403153T GR3006689T3 (el) | 1986-02-27 | 1992-12-28 |
Country Status (15)
Country | Link |
---|---|
US (2) | US4772604A (el) |
EP (1) | EP0241053B1 (el) |
JP (1) | JPH0798800B2 (el) |
AT (1) | ATE82281T1 (el) |
AU (1) | AU585131B2 (el) |
CA (1) | CA1279645C (el) |
DE (1) | DE3782525T2 (el) |
DK (1) | DK93087A (el) |
ES (1) | ES2052545T3 (el) |
GR (1) | GR3006689T3 (el) |
IE (1) | IE61724B1 (el) |
IL (1) | IL81669A (el) |
NZ (1) | NZ219380A (el) |
PH (1) | PH22783A (el) |
ZA (1) | ZA871335B (el) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772604A (en) * | 1986-02-27 | 1988-09-20 | Duphar International Research B.V. | Phenyl-substituted (N-piperazinyl) methylazoles for treating affections in the central nervous system |
US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
US5159083A (en) * | 1990-12-28 | 1992-10-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
US5569659A (en) * | 1991-09-11 | 1996-10-29 | Mcneilab, Inc. | 4-arylpiperazines and 4-arylpiperidines |
IE914218A1 (en) * | 1991-09-11 | 1993-03-24 | Mcneilab Inc | Novel 4-arylpiperazines and 4-arylpiperidines |
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
NZ254784A (en) * | 1992-08-06 | 1996-11-26 | Smithkline Beecham Plc | Substituted 5-phenyl pyrrole derivatives and medicaments |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
GB9306578D0 (en) * | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
GB9307400D0 (en) * | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
JPH08511789A (ja) * | 1993-06-25 | 1996-12-10 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | フェニルピロール誘導体およびドーパミンd3拮抗薬としてのそれらの使用 |
GB9315801D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9315800D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9320855D0 (en) * | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
GB9403199D0 (en) * | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
WO1996016057A1 (en) * | 1994-11-23 | 1996-05-30 | Neurogen Corporation | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands |
US5478934A (en) * | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
GB9512129D0 (en) * | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
US6114334A (en) * | 1995-07-13 | 2000-09-05 | Knoll Aktiengesellschaft | Piperazine derivatives as therapeutic agents |
UA52656C2 (uk) | 1996-03-29 | 2003-01-15 | Дюфар Інтернешнл Рісьоч Б.В. | Похідні піперазину та піперидину, спосіб їх отримання, фармацевтична композиція, спосіб отримання фармацевтичної композиції і спосіб лікування розладів цнс |
CA2275796A1 (en) | 1996-12-23 | 1998-07-02 | Donald Joseph Phillip Pinto | Nitrogen containing heteroaromatics as factor xa inhibitors |
US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
CN1105707C (zh) * | 1997-01-27 | 2003-04-16 | 第一制药株式会社 | 吡唑衍生物 |
TW530054B (en) * | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
US6844295B2 (en) | 2000-07-04 | 2005-01-18 | Ube Industries, Ltd. | Benzoxazole compound, process for producing the same, and herbicide |
DE60231507D1 (de) | 2001-07-20 | 2010-07-01 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
CA2488202C (en) * | 2002-06-12 | 2011-03-08 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US7435830B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
BRPI0405418A (pt) * | 2004-09-02 | 2006-05-02 | Univ Rio De Janeiro | uso de derivados n-fenilperazìnicos e composições farmacêuticas contendo os mesmos |
TW200800946A (en) * | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Substituted piperazines as metabotropic glutamate receptor antagonists |
KR100654328B1 (ko) | 2005-08-26 | 2006-12-08 | 한국과학기술연구원 | 피페라지닐알킬피라졸계 t-타입 칼슘 채널 억제 화합물 및이의 제조방법 |
US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
CN103570705B (zh) * | 2012-07-18 | 2017-01-25 | 中国医学科学院医药生物技术研究所 | 取代的n‑((1',3'‑杂唑‑4'‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途 |
MX2016006603A (es) * | 2013-12-20 | 2016-09-06 | Esteve Labor Dr | Compuestos piperidinicos con actividad multimodal contra el dolor. |
CN105829287B (zh) * | 2013-12-20 | 2019-08-27 | 埃斯蒂文制药股份有限公司 | 具有抗疼痛的多重模式活性的哌嗪衍生物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3407199A (en) * | 1966-01-18 | 1968-10-22 | Endo Lab | Tertiaryamino ethyl or propyl pyrrol-2-yl ketones |
DE2261351A1 (de) * | 1972-12-15 | 1974-06-20 | Merck Patent Gmbh | Pyrazolderivate und verfahren zu ihrer herstellung |
DE2526469A1 (de) * | 1975-06-13 | 1976-12-30 | Bayer Ag | 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4032526A (en) * | 1975-10-02 | 1977-06-28 | American Cyanamid Company | 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts |
US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
DE2747531A1 (de) * | 1977-10-22 | 1979-04-26 | Basf Ag | Substituierte 3-aminopyrazole |
FR2537133A1 (fr) * | 1982-12-07 | 1984-06-08 | Rhone Poulenc Sante | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
NZ209876A (en) * | 1983-10-17 | 1988-03-30 | Duphar Int Res | Piperazines and pharmaceutical compositions |
US4562189A (en) * | 1984-10-09 | 1985-12-31 | American Cyanamid Company | Pyrazolylpiperazines |
DE3442860A1 (de) * | 1984-11-24 | 1986-05-28 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4772604A (en) * | 1986-02-27 | 1988-09-20 | Duphar International Research B.V. | Phenyl-substituted (N-piperazinyl) methylazoles for treating affections in the central nervous system |
-
1987
- 1987-02-24 US US07/018,164 patent/US4772604A/en not_active Expired - Lifetime
- 1987-02-24 IE IE46687A patent/IE61724B1/en not_active IP Right Cessation
- 1987-02-24 NZ NZ219380A patent/NZ219380A/xx unknown
- 1987-02-24 DK DK093087A patent/DK93087A/da not_active Application Discontinuation
- 1987-02-24 AT AT87200296T patent/ATE82281T1/de not_active IP Right Cessation
- 1987-02-24 ES ES87200296T patent/ES2052545T3/es not_active Expired - Lifetime
- 1987-02-24 ZA ZA871335A patent/ZA871335B/xx unknown
- 1987-02-24 IL IL81669A patent/IL81669A/xx not_active IP Right Cessation
- 1987-02-24 PH PH34901A patent/PH22783A/en unknown
- 1987-02-24 EP EP87200296A patent/EP0241053B1/en not_active Expired - Lifetime
- 1987-02-24 DE DE8787200296T patent/DE3782525T2/de not_active Expired - Fee Related
- 1987-02-24 CA CA000530424A patent/CA1279645C/en not_active Expired - Lifetime
- 1987-02-25 AU AU69247/87A patent/AU585131B2/en not_active Ceased
- 1987-02-25 JP JP62040530A patent/JPH0798800B2/ja not_active Expired - Lifetime
-
1988
- 1988-07-01 US US07/214,310 patent/US4874770A/en not_active Expired - Lifetime
-
1992
- 1992-12-28 GR GR920403153T patent/GR3006689T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK93087A (da) | 1987-08-28 |
AU585131B2 (en) | 1989-06-08 |
US4874770A (en) | 1989-10-17 |
CA1279645C (en) | 1991-01-29 |
ZA871335B (en) | 1987-09-30 |
DK93087D0 (da) | 1987-02-24 |
DE3782525D1 (de) | 1992-12-17 |
EP0241053A1 (en) | 1987-10-14 |
IE61724B1 (en) | 1994-11-30 |
NZ219380A (en) | 1990-06-26 |
US4772604A (en) | 1988-09-20 |
IE870466L (en) | 1987-08-27 |
ATE82281T1 (de) | 1992-11-15 |
JPH0798800B2 (ja) | 1995-10-25 |
EP0241053B1 (en) | 1992-11-11 |
JPS62205058A (ja) | 1987-09-09 |
DE3782525T2 (de) | 1993-05-27 |
IL81669A (en) | 1990-11-29 |
ES2052545T3 (es) | 1994-07-16 |
IL81669A0 (en) | 1987-09-16 |
PH22783A (en) | 1988-12-12 |
AU6924787A (en) | 1987-09-03 |
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