NZ212492A - Epoxy steroids with spiro-heterocyclic ring and pharmaceutical compositons - Google Patents
Epoxy steroids with spiro-heterocyclic ring and pharmaceutical compositonsInfo
- Publication number
- NZ212492A NZ212492A NZ212492A NZ21249285A NZ212492A NZ 212492 A NZ212492 A NZ 212492A NZ 212492 A NZ212492 A NZ 212492A NZ 21249285 A NZ21249285 A NZ 21249285A NZ 212492 A NZ212492 A NZ 212492A
- Authority
- NZ
- New Zealand
- Prior art keywords
- spiro
- heterocyclic ring
- pharmaceutical compositons
- epoxy steroids
- steroids
- Prior art date
Links
- 239000004593 Epoxy Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH300984 | 1984-06-21 | ||
| CH464684 | 1984-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ212492A true NZ212492A (en) | 1989-02-24 |
Family
ID=25691934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ212492A NZ212492A (en) | 1984-06-21 | 1985-06-20 | Epoxy steroids with spiro-heterocyclic ring and pharmaceutical compositons |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4670551A (enExample) |
| EP (1) | EP0165902B1 (enExample) |
| AR (2) | AR242036A1 (enExample) |
| AU (1) | AU582754B2 (enExample) |
| CA (1) | CA1239388A (enExample) |
| DE (1) | DE3569540D1 (enExample) |
| DK (1) | DK173854B1 (enExample) |
| ES (2) | ES8704967A1 (enExample) |
| FI (1) | FI83225C (enExample) |
| GR (1) | GR851499B (enExample) |
| HU (1) | HU192232B (enExample) |
| IE (1) | IE58050B1 (enExample) |
| IL (1) | IL75569A (enExample) |
| NO (1) | NO165496C (enExample) |
| NZ (1) | NZ212492A (enExample) |
| PT (1) | PT80663B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384866C (zh) | 1995-12-11 | 2008-04-30 | G·D·瑟尔公司 | 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法 |
| EP1223174A3 (en) * | 1996-12-11 | 2005-03-16 | G.D. Searle & Co. | Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein |
| PT944644E (pt) * | 1996-12-11 | 2003-02-28 | Searle & Co | Processos para a preparacao de esteroides 9,11-epoxi e intermediarios uteis para esse efeito |
| US6887991B1 (en) | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| EP1455795A1 (en) | 2001-12-12 | 2004-09-15 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| US7235655B2 (en) | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| EP2392258B1 (en) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-informatics system |
| WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| PL3395372T3 (pl) | 2009-02-20 | 2022-07-25 | EnhanX Biopharm Inc. | Układ do dostarczania leków na bazie glutationu |
| CN102458374A (zh) | 2009-05-06 | 2012-05-16 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013012A (en) * | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
| US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
| GB1041534A (en) * | 1963-04-24 | 1966-09-07 | Merck & Co Inc | 20-spiroxane compounds |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4559332A (en) * | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| ATE51233T1 (de) * | 1983-08-17 | 1990-04-15 | Schering Ag | 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
-
1985
- 1985-06-13 US US06/744,444 patent/US4670551A/en not_active Expired - Fee Related
- 1985-06-17 EP EP85810277A patent/EP0165902B1/de not_active Expired
- 1985-06-17 DE DE8585810277T patent/DE3569540D1/de not_active Expired
- 1985-06-19 PT PT80663A patent/PT80663B/pt not_active IP Right Cessation
- 1985-06-19 CA CA000484418A patent/CA1239388A/en not_active Expired
- 1985-06-19 GR GR851499A patent/GR851499B/el unknown
- 1985-06-19 IL IL75569A patent/IL75569A/xx not_active IP Right Cessation
- 1985-06-19 FI FI852430A patent/FI83225C/fi not_active IP Right Cessation
- 1985-06-20 ES ES544387A patent/ES8704967A1/es not_active Expired
- 1985-06-20 HU HU852433A patent/HU192232B/hu not_active IP Right Cessation
- 1985-06-20 NO NO852501A patent/NO165496C/no unknown
- 1985-06-20 DK DK198502800A patent/DK173854B1/da not_active IP Right Cessation
- 1985-06-20 IE IE153585A patent/IE58050B1/en not_active IP Right Cessation
- 1985-06-20 NZ NZ212492A patent/NZ212492A/xx unknown
- 1985-06-21 AR AR85300773A patent/AR242036A1/es active
- 1985-06-21 AU AU43971/85A patent/AU582754B2/en not_active Ceased
-
1986
- 1986-10-01 ES ES557112A patent/ES8707737A1/es not_active Expired
-
1989
- 1989-07-31 AR AR89314546A patent/AR245731A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| US4670551A (en) | 1987-06-02 |
| DE3569540D1 (en) | 1989-05-24 |
| FI852430A0 (fi) | 1985-06-19 |
| IL75569A0 (en) | 1985-10-31 |
| CA1239388A (en) | 1988-07-19 |
| IE851535L (en) | 1985-12-21 |
| PT80663B (en) | 1987-05-08 |
| NO165496B (no) | 1990-11-12 |
| NO165496C (no) | 1991-02-20 |
| DK280085A (da) | 1985-12-22 |
| EP0165902A2 (de) | 1985-12-27 |
| PT80663A (en) | 1985-07-01 |
| DK280085D0 (da) | 1985-06-20 |
| FI83225C (fi) | 1991-06-10 |
| ES8707737A1 (es) | 1987-08-16 |
| HU192232B (en) | 1987-05-28 |
| AR245731A1 (es) | 1994-02-28 |
| IL75569A (en) | 1989-03-31 |
| ES8704967A1 (es) | 1987-04-16 |
| IE58050B1 (en) | 1993-06-16 |
| FI852430L (fi) | 1985-12-22 |
| AU582754B2 (en) | 1989-04-13 |
| DK173854B1 (da) | 2001-12-27 |
| ES557112A0 (es) | 1987-08-16 |
| GR851499B (enExample) | 1985-11-25 |
| ES544387A0 (es) | 1987-04-16 |
| AU4397185A (en) | 1986-01-02 |
| HUT38367A (en) | 1986-05-28 |
| NO852501L (no) | 1985-12-23 |
| AR242036A1 (es) | 1993-02-26 |
| EP0165902A3 (en) | 1986-10-22 |
| FI83225B (fi) | 1991-02-28 |
| EP0165902B1 (de) | 1989-04-19 |
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