AU582754B2 - Epoxy steroids - Google Patents

Epoxy steroids

Info

Publication number
AU582754B2
AU582754B2 AU43971/85A AU4397185A AU582754B2 AU 582754 B2 AU582754 B2 AU 582754B2 AU 43971/85 A AU43971/85 A AU 43971/85A AU 4397185 A AU4397185 A AU 4397185A AU 582754 B2 AU582754 B2 AU 582754B2
Authority
AU
Australia
Prior art keywords
acid
epoxy
component
solution
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU43971/85A
Other languages
English (en)
Other versions
AU4397185A (en
Inventor
Michel Biollaz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU4397185A publication Critical patent/AU4397185A/en
Application granted granted Critical
Publication of AU582754B2 publication Critical patent/AU582754B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: CIBA-GEIGY AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU43971/85A 1984-06-21 1985-06-21 Epoxy steroids Ceased AU582754B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH3009/84 1984-06-21
CH300984 1984-06-21
CH464684 1984-09-28
CH4646/84 1984-09-28

Publications (2)

Publication Number Publication Date
AU4397185A AU4397185A (en) 1986-01-02
AU582754B2 true AU582754B2 (en) 1989-04-13

Family

ID=25691934

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43971/85A Ceased AU582754B2 (en) 1984-06-21 1985-06-21 Epoxy steroids

Country Status (16)

Country Link
US (1) US4670551A (enExample)
EP (1) EP0165902B1 (enExample)
AR (2) AR242036A1 (enExample)
AU (1) AU582754B2 (enExample)
CA (1) CA1239388A (enExample)
DE (1) DE3569540D1 (enExample)
DK (1) DK173854B1 (enExample)
ES (2) ES8704967A1 (enExample)
FI (1) FI83225C (enExample)
GR (1) GR851499B (enExample)
HU (1) HU192232B (enExample)
IE (1) IE58050B1 (enExample)
IL (1) IL75569A (enExample)
NO (1) NO165496C (enExample)
NZ (1) NZ212492A (enExample)
PT (1) PT80663B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021720A2 (en) 1995-12-11 1997-06-19 G.D. Searle And Co. Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
EP1148061B1 (en) * 1996-12-11 2007-10-17 G.D. Searle LLC. Epoxidation process
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
WO2003049745A1 (en) 2001-12-12 2003-06-19 Pharmacia Corporation Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122232A1 (de) * 1983-04-13 1984-10-17 Ciba-Geigy Ag 20-Spiroxane und Analoge mit geöffnetem Ring E, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate davon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) * 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3481707D1 (de) * 1983-08-17 1990-04-26 Schering Ag 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en-21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122232A1 (de) * 1983-04-13 1984-10-17 Ciba-Geigy Ag 20-Spiroxane und Analoge mit geöffnetem Ring E, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate davon

Also Published As

Publication number Publication date
NZ212492A (en) 1989-02-24
FI852430A0 (fi) 1985-06-19
DK173854B1 (da) 2001-12-27
DK280085A (da) 1985-12-22
AU4397185A (en) 1986-01-02
DK280085D0 (da) 1985-06-20
FI83225C (fi) 1991-06-10
IE58050B1 (en) 1993-06-16
PT80663A (en) 1985-07-01
EP0165902A3 (en) 1986-10-22
IL75569A (en) 1989-03-31
HUT38367A (en) 1986-05-28
US4670551A (en) 1987-06-02
EP0165902B1 (de) 1989-04-19
AR245731A1 (es) 1994-02-28
NO852501L (no) 1985-12-23
EP0165902A2 (de) 1985-12-27
IL75569A0 (en) 1985-10-31
ES8704967A1 (es) 1987-04-16
FI83225B (fi) 1991-02-28
FI852430L (fi) 1985-12-22
GR851499B (enExample) 1985-11-25
ES544387A0 (es) 1987-04-16
NO165496C (no) 1991-02-20
NO165496B (no) 1990-11-12
DE3569540D1 (en) 1989-05-24
ES8707737A1 (es) 1987-08-16
AR242036A1 (es) 1993-02-26
CA1239388A (en) 1988-07-19
HU192232B (en) 1987-05-28
IE851535L (en) 1985-12-21
ES557112A0 (es) 1987-08-16
PT80663B (en) 1987-05-08

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired