NZ196586A - Modified pasteurella bacteria and modified live pasteurella vaccine; preparation thereof - Google Patents
Modified pasteurella bacteria and modified live pasteurella vaccine; preparation thereofInfo
- Publication number
- NZ196586A NZ196586A NZ196586A NZ19658681A NZ196586A NZ 196586 A NZ196586 A NZ 196586A NZ 196586 A NZ196586 A NZ 196586A NZ 19658681 A NZ19658681 A NZ 19658681A NZ 196586 A NZ196586 A NZ 196586A
- Authority
- NZ
- New Zealand
- Prior art keywords
- vaccine
- modified
- pasteurella
- modified live
- bacteria
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims description 94
- 241000606860 Pasteurella Species 0.000 title claims description 36
- 238000002360 preparation method Methods 0.000 title claims description 10
- 241001465754 Metazoa Species 0.000 claims description 71
- 241000606856 Pasteurella multocida Species 0.000 claims description 71
- 229940051027 pasteurella multocida Drugs 0.000 claims description 63
- 241001293418 Mannheimia haemolytica Species 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 41
- 241000283690 Bos taurus Species 0.000 claims description 32
- 230000008569 process Effects 0.000 claims description 21
- 241000894006 Bacteria Species 0.000 claims description 20
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims description 19
- VWXAJKFSYJFBIW-UHFFFAOYSA-N acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride;trihydrochloride Chemical group Cl.Cl.Cl.[Cl-].C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21.C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 VWXAJKFSYJFBIW-UHFFFAOYSA-N 0.000 claims description 15
- 239000002609 medium Substances 0.000 claims description 15
- 238000002255 vaccination Methods 0.000 claims description 14
- 239000003381 stabilizer Substances 0.000 claims description 12
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 11
- 239000001963 growth medium Substances 0.000 claims description 11
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 11
- 229960003495 thiamine Drugs 0.000 claims description 11
- 235000019157 thiamine Nutrition 0.000 claims description 11
- 239000011721 thiamine Substances 0.000 claims description 11
- 238000007920 subcutaneous administration Methods 0.000 claims description 10
- 238000007918 intramuscular administration Methods 0.000 claims description 9
- 230000012010 growth Effects 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 8
- 241000894007 species Species 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 238000007385 chemical modification Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 4
- 230000036039 immunity Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 108010023063 Bacto-peptone Proteins 0.000 claims description 3
- 229940041514 candida albicans extract Drugs 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 239000012138 yeast extract Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000003698 anagen phase Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 244000309466 calf Species 0.000 description 14
- 230000000994 depressogenic effect Effects 0.000 description 12
- 238000011534 incubation Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241001494479 Pecora Species 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 description 5
- 208000008939 Pneumonic Pasteurellosis Diseases 0.000 description 5
- 229940023020 acriflavine Drugs 0.000 description 5
- 239000006161 blood agar Substances 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 241000271566 Aves Species 0.000 description 4
- 241000699800 Cricetinae Species 0.000 description 4
- 206010034107 Pasteurella infections Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 3
- 238000011887 Necropsy Methods 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 206010035664 Pneumonia Diseases 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 235000013330 chicken meat Nutrition 0.000 description 3
- 201000005115 pasteurellosis Diseases 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 208000023504 respiratory system disease Diseases 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 241000712005 Bovine respirovirus 3 Species 0.000 description 2
- 238000009631 Broth culture Methods 0.000 description 2
- 206010008631 Cholera Diseases 0.000 description 2
- 208000032969 Hemorrhagic Septicemia Diseases 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 208000014645 Pasteurella hemorrhagic septicemia Diseases 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 206010038687 Respiratory distress Diseases 0.000 description 2
- 206010051497 Rhinotracheitis Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229940001442 combination vaccine Drugs 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 208000030175 lameness Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 2
- 229940116357 potassium thiocyanate Drugs 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- PUMZXCBVHLCWQG-UHFFFAOYSA-N 1-(4-Hydroxyphenyl)-2-aminoethanol hydrochloride Chemical compound [Cl-].[NH3+]CC(O)C1=CC=C(O)C=C1 PUMZXCBVHLCWQG-UHFFFAOYSA-N 0.000 description 1
- DPKYKAJWJUVGLX-UHFFFAOYSA-N 10-methylacridin-10-ium-1,2-diamine;chloride Chemical compound [Cl-].NC1=CC=C2[N+](C)=C(C=CC=C3)C3=CC2=C1N DPKYKAJWJUVGLX-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 201000008283 Atrophic Rhinitis Diseases 0.000 description 1
- 201000001178 Bacterial Pneumonia Diseases 0.000 description 1
- 241000157302 Bison bison athabascae Species 0.000 description 1
- 241000588779 Bordetella bronchiseptica Species 0.000 description 1
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010014824 Endotoxic shock Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- -1 ION sodium hydroxide Chemical class 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 241000190661 Mannheimia haemolytica serotype 1 Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 244000309725 Pasteurella multocida type A Species 0.000 description 1
- 206010039088 Rhinitis atrophic Diseases 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
- RBQZABSXOWRSDF-UHFFFAOYSA-N acridine-1,2-diamine;hydrochloride Chemical compound Cl.C1=CC=CC2=CC3=C(N)C(N)=CC=C3N=C21 RBQZABSXOWRSDF-UHFFFAOYSA-N 0.000 description 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-O acridine;hydron Chemical class C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-O 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229960005004 cholera vaccine Drugs 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 229960001576 octopamine Drugs 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000005801 respiratory difficulty Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 208000026425 severe pneumonia Diseases 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/823—Bacterial vaccine for bovine species, e.g. cattle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/824—Bacterial vaccine for ovine species, e.g. sheep
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/135,828 US4293545A (en) | 1980-03-31 | 1980-03-31 | Modified Pasteurella multocida bacteria vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ196586A true NZ196586A (en) | 1984-05-31 |
Family
ID=22469886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ196586A NZ196586A (en) | 1980-03-31 | 1981-03-23 | Modified pasteurella bacteria and modified live pasteurella vaccine; preparation thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4293545A (enExample) |
| EP (1) | EP0036995B1 (enExample) |
| AR (1) | AR227543A1 (enExample) |
| AT (1) | ATE5682T1 (enExample) |
| AU (1) | AU545276B2 (enExample) |
| CA (1) | CA1162480A (enExample) |
| DE (1) | DE3161739D1 (enExample) |
| DK (1) | DK152664C (enExample) |
| ES (1) | ES8302086A1 (enExample) |
| GR (1) | GR74844B (enExample) |
| IE (1) | IE51715B1 (enExample) |
| NO (1) | NO159805C (enExample) |
| NZ (1) | NZ196586A (enExample) |
| PT (1) | PT72671B (enExample) |
| ZA (1) | ZA811919B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743553A (en) * | 1984-07-18 | 1988-05-10 | W. R. Grace & Co. | Synthetic genes for bovine parainfluenza virus |
| ES2059503T5 (es) * | 1987-03-24 | 2000-01-16 | Btg International Limited Comp | Procedimiento para preparar una vacuna contra pasteurella. |
| US5885589A (en) * | 1988-04-12 | 1999-03-23 | Intervet International B.V. | Pasteurella vaccine |
| DK199588D0 (da) * | 1988-04-12 | 1988-04-12 | Nordisk Droge & Kemikalie | Vaccine |
| US4999191A (en) * | 1988-05-05 | 1991-03-12 | University Of Georgia Research Foundation, Inc. | Pasteurella multocida vaccine |
| AU5591694A (en) * | 1992-11-06 | 1994-06-08 | Regents Of The University Of Minnesota | Composition protective against (p. multocida) pasteurellosis infection |
| US5587305A (en) * | 1993-12-06 | 1996-12-24 | The United States Of America As Represented By The Department Of Agriculture | Pasteurella haemolytica transformants |
| US6793927B1 (en) | 1993-12-06 | 2004-09-21 | The United States Of America As Represented By The Secretary Of The Department Of Agriculture | Construction of Pasteurella haemolytica vaccines |
| EP3062816B1 (en) | 2013-11-01 | 2020-08-05 | Boehringer Ingelheim Animal Health USA Inc. | Attenuated pasteurella multocida vaccines & methods of making & use thereof |
| CN112843228B (zh) * | 2021-04-10 | 2022-10-14 | 福建省农业科学院畜牧兽医研究所 | 一种兔巴氏杆菌病二价灭活疫苗及其制备方法 |
| CN113046271B (zh) * | 2021-04-10 | 2022-10-14 | 福建省农业科学院畜牧兽医研究所 | 一株兔f型多杀性巴氏杆菌及其在制备灭活疫苗中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3501770A (en) * | 1967-04-13 | 1970-03-17 | Lilly Co Eli | Shipping fever vaccine |
| US3526696A (en) * | 1968-02-14 | 1970-09-01 | Lilly Co Eli | Shipping fever vaccine |
| US3634587A (en) * | 1969-11-06 | 1972-01-11 | Ralston Purina Co | Method of immunizing cattle against bovine respiratory disease syndrome |
| GB1441098A (en) | 1972-03-29 | 1976-06-30 | Wellcome Found | Biological preparations |
| US3855408A (en) * | 1973-07-16 | 1974-12-17 | Univ Minnesota | Poultry vaccine |
| CA1030873A (en) | 1973-10-09 | 1978-05-09 | Jagmahan Bhasin | Immunizing agent for poultry |
| FR2360314A2 (fr) | 1976-08-06 | 1978-03-03 | Fabre Sa Pierre | Nouveaux vaccins perfectionnes a base de fractions ribosomales |
| US4167560A (en) * | 1977-04-12 | 1979-09-11 | Texas Vet Lab, Inc. | Polyvalent shipping fever vaccine |
| AT350181B (de) | 1977-05-04 | 1979-05-10 | Schuller Walter Dr | Verfahren zur herstellung einer mischvaccine |
| US4171354A (en) * | 1977-06-23 | 1979-10-16 | Ohio Agricultural Research And Development Center | Vaccine for animal respiratory diseases |
| IL52815A (en) * | 1977-08-24 | 1983-03-31 | Israel State | Fowl cholera vaccine and process for producing an attenuated non-virulent strain of pasteurella multocida |
| CA1133829A (en) | 1978-08-24 | 1982-10-19 | Neil J.L. Gilmour | Pasteurellosis vaccines |
-
1980
- 1980-03-31 US US06/135,828 patent/US4293545A/en not_active Expired - Lifetime
-
1981
- 1981-03-16 DE DE8181101921T patent/DE3161739D1/de not_active Expired
- 1981-03-16 AU AU68381/81A patent/AU545276B2/en not_active Expired
- 1981-03-16 EP EP81101921A patent/EP0036995B1/en not_active Expired
- 1981-03-16 AT AT81101921T patent/ATE5682T1/de active
- 1981-03-17 DK DK118781A patent/DK152664C/da not_active IP Right Cessation
- 1981-03-17 PT PT72671A patent/PT72671B/pt unknown
- 1981-03-19 NO NO810938A patent/NO159805C/no not_active IP Right Cessation
- 1981-03-20 IE IE618/81A patent/IE51715B1/en not_active IP Right Cessation
- 1981-03-23 ZA ZA00811919A patent/ZA811919B/xx unknown
- 1981-03-23 NZ NZ196586A patent/NZ196586A/en unknown
- 1981-03-26 GR GR64492A patent/GR74844B/el unknown
- 1981-03-26 ES ES500722A patent/ES8302086A1/es not_active Expired
- 1981-03-27 AR AR284774A patent/AR227543A1/es active
- 1981-03-30 CA CA000374195A patent/CA1162480A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK152664C (da) | 1988-08-22 |
| ZA811919B (en) | 1982-05-26 |
| ATE5682T1 (de) | 1984-01-15 |
| NO159805C (no) | 1989-02-08 |
| NO810938L (no) | 1981-10-01 |
| IE51715B1 (en) | 1987-03-04 |
| AR227543A1 (es) | 1982-11-15 |
| AU545276B2 (en) | 1985-07-11 |
| ES500722A0 (es) | 1983-01-01 |
| DK118781A (da) | 1981-10-01 |
| ES8302086A1 (es) | 1983-01-01 |
| PT72671A (en) | 1981-04-01 |
| AU6838181A (en) | 1981-10-22 |
| NO159805B (no) | 1988-10-31 |
| EP0036995B1 (en) | 1983-12-28 |
| DE3161739D1 (en) | 1984-02-02 |
| PT72671B (en) | 1982-03-22 |
| US4293545A (en) | 1981-10-06 |
| DK152664B (da) | 1988-04-11 |
| EP0036995A1 (en) | 1981-10-07 |
| IE810618L (en) | 1981-09-30 |
| CA1162480A (en) | 1984-02-21 |
| GR74844B (enExample) | 1984-07-12 |
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