NZ193695A - Pharmaceutical compositions containing n-cyclobutylmethyl-14-hydroxydihydronormorphine (nalbuphine) and n-(4-hydroxyphenyl)-acetamide (acetaminophen) - Google Patents

Pharmaceutical compositions containing n-cyclobutylmethyl-14-hydroxydihydronormorphine (nalbuphine) and n-(4-hydroxyphenyl)-acetamide (acetaminophen)

Info

Publication number
NZ193695A
NZ193695A NZ193695A NZ19369580A NZ193695A NZ 193695 A NZ193695 A NZ 193695A NZ 193695 A NZ193695 A NZ 193695A NZ 19369580 A NZ19369580 A NZ 19369580A NZ 193695 A NZ193695 A NZ 193695A
Authority
NZ
New Zealand
Prior art keywords
nalbuphine
acetaminophen
composition
analgesic
mammal
Prior art date
Application number
NZ193695A
Other languages
English (en)
Inventor
J R Dudzinski
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of NZ193695A publication Critical patent/NZ193695A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ193695A 1979-05-18 1980-05-13 Pharmaceutical compositions containing n-cyclobutylmethyl-14-hydroxydihydronormorphine (nalbuphine) and n-(4-hydroxyphenyl)-acetamide (acetaminophen) NZ193695A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/040,281 US4237140A (en) 1979-05-18 1979-05-18 Analgesic mixture of nalbuphine and acetaminophen

Publications (1)

Publication Number Publication Date
NZ193695A true NZ193695A (en) 1984-05-31

Family

ID=21910135

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ193695A NZ193695A (en) 1979-05-18 1980-05-13 Pharmaceutical compositions containing n-cyclobutylmethyl-14-hydroxydihydronormorphine (nalbuphine) and n-(4-hydroxyphenyl)-acetamide (acetaminophen)

Country Status (12)

Country Link
US (1) US4237140A (OSRAM)
EP (1) EP0019282B1 (OSRAM)
JP (1) JPS55154917A (OSRAM)
AU (1) AU529764B2 (OSRAM)
CA (1) CA1139671A (OSRAM)
DE (1) DE3061597D1 (OSRAM)
HU (1) HU178867B (OSRAM)
IE (1) IE49988B1 (OSRAM)
IL (1) IL60095A (OSRAM)
NZ (1) NZ193695A (OSRAM)
PH (1) PH15265A (OSRAM)
ZA (1) ZA802916B (OSRAM)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
US4366159A (en) * 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4404211A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and flurbiprofen
US4407804A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and indomethacin
US4404208A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and tiflamizole
US4404210A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and ibuprofen
US4407805A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and zomepirac
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
US4402962A (en) * 1982-06-30 1983-09-06 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole
AU565634B2 (en) * 1982-06-30 1987-09-24 E.I. Du Pont De Nemours And Company Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
GB2134786B (en) * 1982-07-22 1986-05-08 Richardson Vicks Inc Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4656177A (en) * 1982-07-22 1987-04-07 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4777174A (en) * 1982-07-22 1988-10-11 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4722928A (en) * 1985-12-02 1988-02-02 E. I. Du Pont De Nemours And Company N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes
KR100243956B1 (ko) 1991-09-06 2000-03-02 랄프 알. 팔로 트라마돌 물질 및 아세트아미노펜을 포함하는 통증 치료용 약제학적 조성물
US5558876A (en) * 1995-03-29 1996-09-24 Alcon Laboratories, Inc. Topical ophthalmic acidic drug formulations
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
RU2241458C2 (ru) 1997-12-22 2004-12-10 Эро-Селтик, С.А. Комбинации агонист/антагонист опиоида
ES2539904T3 (es) 2000-02-08 2015-07-07 Euro-Celtique S.A. Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
AU2002305559B2 (en) 2001-05-11 2008-04-03 Mundipharma Pty Limited Abuse-resistant controlled-release opioid dosage form
JP4256259B2 (ja) 2001-07-18 2009-04-22 ユーロ−セルティーク エス．エイ． オキシコドン及びナロキソンの医薬配合物
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
PL367427A1 (en) 2001-08-06 2005-02-21 Euro-Celtique S.A. Opioid agonist formulations with releasable and sequestered antagonist
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
DE60325567D1 (de) 2002-04-05 2009-02-12 Euro Celtique Sa Matrix für die modifizierte freigabe von aktiven substanzen
CA2499550C (en) 2002-09-20 2013-10-15 Alpharma, Inc. Sequestering subunit and related compositions and methods
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US8394812B2 (en) 2005-08-24 2013-03-12 Penwest Pharmaceuticals Co. Sustained release formulations of nalbuphine
PT1931315E (pt) * 2005-08-24 2014-01-03 Endo Pharmaceuticals Inc Formulações de libertação sustentada de nalbufina
EP2719378B1 (en) 2006-06-19 2016-08-31 Alpharma Pharmaceuticals LLC Pharmaceutical compositions
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
ES2706407T3 (es) 2009-03-10 2019-03-28 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona
EA201600033A1 (ru) 2013-07-23 2016-10-31 Еуро-Селтик С.А. Комбинация оксикодона и налоксона для лечения боли у пациентов, страдающих от боли и заболевания, приводящего к дисбиозу кишечника и/или повышению риска транслокации кишечной микрофлоры
IL282010B (en) 2013-12-24 2022-07-01 Univ Virginia Commonwealth Uses of oxidized cholesterol sulfates
JOP20190094A1 (ar) * 2016-10-27 2019-04-25 Broad Inst Inc مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
WO2019070917A1 (en) * 2017-10-03 2019-04-11 The Schepens Eye Research Institute, Inc. COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE DEGENERATION OF RETINAL PIGMENT EPITHELIUM AND METHODS USING SAME
WO2020047703A1 (en) * 2018-09-03 2020-03-12 National Defense Education And Research Foundation Pharmaceutical preparations of sebacoyl dinalbuphine and acetaminophen and methods for treating pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4029798A (en) * 1975-06-02 1977-06-14 Sumitomo Chemical Company, Limited Analgetic composition
JPS5946205B2 (ja) * 1976-01-01 1984-11-10 科研製薬株式会社 ベンゾイル誘導体を有効成分とする消炎鎮痛剤

Also Published As

Publication number Publication date
JPH0144684B2 (OSRAM) 1989-09-29
IL60095A0 (en) 1980-07-31
IE801019L (en) 1980-11-18
US4237140A (en) 1980-12-02
CA1139671A (en) 1983-01-18
HU178867B (en) 1982-07-28
EP0019282B1 (en) 1983-01-12
DE3061597D1 (en) 1983-02-17
IL60095A (en) 1982-12-31
ZA802916B (en) 1981-12-30
AU529764B2 (en) 1983-06-16
EP0019282A1 (en) 1980-11-26
PH15265A (en) 1982-11-02
AU5835180A (en) 1980-11-20
IE49988B1 (en) 1986-01-22
JPS55154917A (en) 1980-12-02

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