IL60095A - Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen - Google Patents
Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophenInfo
- Publication number
- IL60095A IL60095A IL60095A IL6009580A IL60095A IL 60095 A IL60095 A IL 60095A IL 60095 A IL60095 A IL 60095A IL 6009580 A IL6009580 A IL 6009580A IL 60095 A IL60095 A IL 60095A
- Authority
- IL
- Israel
- Prior art keywords
- nalbuphine
- acetaminophen
- pharmaceutical compositions
- analgesic pharmaceutical
- synergistic analgesic
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 2
- 230000000202 analgesic effect Effects 0.000 title 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 title 1
- 229960000805 nalbuphine Drugs 0.000 title 1
- 229960005489 paracetamol Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/040,281 US4237140A (en) | 1979-05-18 | 1979-05-18 | Analgesic mixture of nalbuphine and acetaminophen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL60095A0 IL60095A0 (en) | 1980-07-31 |
| IL60095A true IL60095A (en) | 1982-12-31 |
Family
ID=21910135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL60095A IL60095A (en) | 1979-05-18 | 1980-05-16 | Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4237140A (OSRAM) |
| EP (1) | EP0019282B1 (OSRAM) |
| JP (1) | JPS55154917A (OSRAM) |
| AU (1) | AU529764B2 (OSRAM) |
| CA (1) | CA1139671A (OSRAM) |
| DE (1) | DE3061597D1 (OSRAM) |
| HU (1) | HU178867B (OSRAM) |
| IE (1) | IE49988B1 (OSRAM) |
| IL (1) | IL60095A (OSRAM) |
| NZ (1) | NZ193695A (OSRAM) |
| PH (1) | PH15265A (OSRAM) |
| ZA (1) | ZA802916B (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322427A (en) * | 1981-04-16 | 1982-03-30 | Bristol-Myers Company | Analgetic compositions and methods of use |
| US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
| US4404210A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and ibuprofen |
| US4407804A (en) * | 1982-06-30 | 1983-10-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and indomethacin |
| US4404209A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and sulindac |
| US4404211A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and flurbiprofen |
| US4407805A (en) * | 1982-06-30 | 1983-10-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and zomepirac |
| US4404208A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| AU565634B2 (en) * | 1982-06-30 | 1987-09-24 | E.I. Du Pont De Nemours And Company | Synergistic compositions of nalbuphine and non-narcotic analgesic compounds |
| US4402962A (en) * | 1982-06-30 | 1983-09-06 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole |
| CH659391A5 (de) * | 1982-07-22 | 1987-01-30 | Richardson Vicks Inc | Koffein enthaltende, analgetische und antiinflammatorische pharmazeutische zubereitung. |
| US4777174A (en) * | 1982-07-22 | 1988-10-11 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4656177A (en) * | 1982-07-22 | 1987-04-07 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
| US4722928A (en) * | 1985-12-02 | 1988-02-02 | E. I. Du Pont De Nemours And Company | N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes |
| JP3381190B2 (ja) | 1991-09-06 | 2003-02-24 | マクニーラブ・インコーポレーテツド | トラマドール物質およびアセトアミノフェンを含んでなる組成物並びにそれの使用 |
| US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| TR200001942T2 (tr) | 1997-12-22 | 2000-11-21 | Euro-Celtique, S.A. | Opioid agonist/antagonist kombinasyonlar |
| PT1255547E (pt) | 2000-02-08 | 2008-11-24 | Euro Celtique Sa | Composições de libertação controlada contendo agonistas e antagonistas opióides |
| EP1387673B1 (en) | 2001-05-11 | 2010-12-29 | Endo Pharmaceuticals Inc. | Abuse-resistant controlled-release opioid dosage form |
| SI1416842T1 (sl) | 2001-07-18 | 2009-06-30 | Euro Celtique Sa | Farmacevtske kombinacije oksikodona in naloksona |
| DK1414451T3 (da) | 2001-08-06 | 2009-08-10 | Euro Celtique Sa | Opioidagonistformuleringer med frigivelig og sekvenstreret antagonist |
| US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| WO2003013433A2 (en) | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Sequestered antagonist formulations |
| TWI334779B (en) | 2002-04-05 | 2010-12-21 | Euro Celtique Sa | Pharmaceutical preparation containing oxycodone and naloxone |
| PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| US8394812B2 (en) | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
| DK1931315T3 (da) | 2005-08-24 | 2014-01-20 | Endo Pharmaceuticals Inc | Depotformuleringer af nalbufin |
| CA2655835C (en) | 2006-06-19 | 2015-07-21 | Alpharma, Inc. | Abuse-resistant pharmaceutical compositions of opioid agonists |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| TR201900199T4 (tr) | 2009-03-10 | 2019-02-21 | Euro Celtique Sa | Oksikodon ve nalokson içeren çabuk salımlı farmasötik bileşimler. |
| MY183489A (en) | 2013-07-23 | 2021-02-22 | Euro Celtique Sa | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
| EA032777B1 (ru) | 2013-12-24 | 2019-07-31 | Вирджиния Коммонвелт Юниверсити | Способ предотвращения или лечения почечной недостаточности |
| JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| WO2019070917A1 (en) * | 2017-10-03 | 2019-04-11 | The Schepens Eye Research Institute, Inc. | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE DEGENERATION OF RETINAL PIGMENT EPITHELIUM AND METHODS USING SAME |
| EP3846815A4 (en) * | 2018-09-03 | 2022-05-04 | Jacob Biotech Ltd | Pharmaceutical preparations of sebacoyl dinalbuphine and acetaminophen and methods for treating pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
| US4029798A (en) * | 1975-06-02 | 1977-06-14 | Sumitomo Chemical Company, Limited | Analgetic composition |
| JPS5946205B2 (ja) * | 1976-01-01 | 1984-11-10 | 科研製薬株式会社 | ベンゾイル誘導体を有効成分とする消炎鎮痛剤 |
-
1979
- 1979-05-18 US US06/040,281 patent/US4237140A/en not_active Expired - Lifetime
-
1980
- 1980-05-13 AU AU58351/80A patent/AU529764B2/en not_active Ceased
- 1980-05-13 NZ NZ193695A patent/NZ193695A/en unknown
- 1980-05-15 DE DE8080102696T patent/DE3061597D1/de not_active Expired
- 1980-05-15 EP EP80102696A patent/EP0019282B1/en not_active Expired
- 1980-05-15 CA CA000352011A patent/CA1139671A/en not_active Expired
- 1980-05-16 IE IE1019/80A patent/IE49988B1/en not_active IP Right Cessation
- 1980-05-16 ZA ZA00802916A patent/ZA802916B/xx unknown
- 1980-05-16 PH PH24035A patent/PH15265A/en unknown
- 1980-05-16 IL IL60095A patent/IL60095A/xx unknown
- 1980-05-16 HU HU80801223A patent/HU178867B/hu not_active IP Right Cessation
- 1980-05-17 JP JP6469980A patent/JPS55154917A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE49988B1 (en) | 1986-01-22 |
| JPS55154917A (en) | 1980-12-02 |
| NZ193695A (en) | 1984-05-31 |
| HU178867B (en) | 1982-07-28 |
| DE3061597D1 (en) | 1983-02-17 |
| US4237140A (en) | 1980-12-02 |
| AU529764B2 (en) | 1983-06-16 |
| IL60095A0 (en) | 1980-07-31 |
| CA1139671A (en) | 1983-01-18 |
| IE801019L (en) | 1980-11-18 |
| EP0019282B1 (en) | 1983-01-12 |
| JPH0144684B2 (OSRAM) | 1989-09-29 |
| AU5835180A (en) | 1980-11-20 |
| EP0019282A1 (en) | 1980-11-26 |
| PH15265A (en) | 1982-11-02 |
| ZA802916B (en) | 1981-12-30 |
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