NZ193469A - Hybridoma for producing monoclonal antibody to human t cells and cutaneous t lymphoma cells;antibody;therapeutic compositions and diagnostic methods - Google Patents
Hybridoma for producing monoclonal antibody to human t cells and cutaneous t lymphoma cells;antibody;therapeutic compositions and diagnostic methodsInfo
- Publication number
- NZ193469A NZ193469A NZ193469A NZ19346980A NZ193469A NZ 193469 A NZ193469 A NZ 193469A NZ 193469 A NZ193469 A NZ 193469A NZ 19346980 A NZ19346980 A NZ 19346980A NZ 193469 A NZ193469 A NZ 193469A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cells
- antibody
- hybridoma
- normal human
- monoclonal antibody
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Public Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/033,669 US4361549A (en) | 1979-04-26 | 1979-04-26 | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ193469A true NZ193469A (en) | 1984-07-06 |
Family
ID=21871750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ193469A NZ193469A (en) | 1979-04-26 | 1980-04-17 | Hybridoma for producing monoclonal antibody to human t cells and cutaneous t lymphoma cells;antibody;therapeutic compositions and diagnostic methods |
Country Status (22)
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582797A (en) * | 1980-09-25 | 1986-04-15 | The Salk Institute For Biological Studies | Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins |
| DE3105150A1 (de) * | 1981-02-12 | 1982-08-19 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Herstellung von anti-t-lymphozyten-globulin. |
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4657852A (en) * | 1982-04-02 | 1987-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | Method for B cell typing of total human lymphocyte sample |
| US4471056A (en) * | 1982-04-02 | 1984-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for HLA-DR typing of total human lymphocyte sample |
| US4511662A (en) * | 1982-06-18 | 1985-04-16 | Bio-Rad Laboratories, Inc. | Simultaneous assay for T and B lymphocyte populations and subpopulations |
| US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
| US4500637A (en) * | 1982-07-19 | 1985-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | Prevention of graft versus host disease following bone marrow transplantation |
| US4714613A (en) * | 1982-09-30 | 1987-12-22 | The Albert Einstein College Of Medicine Of Yeshiva University | Method of suppressing cell growth by immunotherapy |
| US4550086A (en) * | 1983-02-16 | 1985-10-29 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies that recognize human T cells |
| US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
| US4797475A (en) * | 1983-05-20 | 1989-01-10 | The Regents Of The University Of California | Method and composition for isolating white cell elements |
| US4645738A (en) * | 1983-09-30 | 1987-02-24 | Memorial Sloan-Kettering Institute Cancer Center | Method for differential diagnosis of T cell leukemias using monoclonal antibodies |
| US4468346A (en) * | 1983-10-27 | 1984-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Monoclonal antibodies to porcine immunoglobulins |
| JPS60231699A (ja) * | 1983-11-09 | 1985-11-18 | Aichiken | 正常及び悪性ヒト造血器細胞に対するモノクローナル抗体 |
| US4672044A (en) * | 1984-08-24 | 1987-06-09 | Scripps Clinic & Research Foundation | Murine monoclonal antibody combining site to human C3b receptor (CR1) |
| US4661446A (en) * | 1985-02-19 | 1987-04-28 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies and method of immunizing therewith |
| US5431897A (en) * | 1985-04-19 | 1995-07-11 | Sloan-Kettering Institute For Cancer Research | Method of imaging colorectal carcinoma lesion and composition for use therein |
| US5091178A (en) * | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
| US4970299A (en) * | 1986-07-03 | 1990-11-13 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies selective for prostate cancer |
| CA1306430C (en) * | 1987-10-16 | 1992-08-18 | Kenneth Francis Bradstock | Monoclonal antibody |
| US5601819A (en) * | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| CA2003455C (en) * | 1988-11-23 | 2000-02-22 | Craig B. Thompson | Immunotherapy involving cd28 stimulation |
| JPH0291833U (US06623731-20030923-C00012.png) * | 1988-12-29 | 1990-07-20 | ||
| JPH0277212U (US06623731-20030923-C00012.png) * | 1989-01-25 | 1990-06-13 | ||
| US6406696B1 (en) | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| CA2071478A1 (en) * | 1989-10-27 | 1991-04-28 | Jeffery A. Bluestone | Methods and compositions for promoting immunopotentiation |
| JPH0420550U (US06623731-20030923-C00012.png) * | 1990-06-11 | 1992-02-20 | ||
| US5444155A (en) * | 1991-09-10 | 1995-08-22 | The Scripps Research Institute | Molecules with antibody combining sites that induce asymmetry |
| US5250426A (en) * | 1991-10-22 | 1993-10-05 | The Scripps Research Institute | Molecules with antibody combining sites that induce asymmetry |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| US20030108548A1 (en) * | 1993-06-01 | 2003-06-12 | Bluestone Jeffrey A. | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| EP2057999A3 (en) | 1995-12-22 | 2009-07-29 | Immunomedics, Inc. | Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines |
| PT963377E (pt) | 1996-08-30 | 2009-05-11 | Human Genome Sciences Inc | Interleucina 19 |
| US6498006B2 (en) | 1997-11-24 | 2002-12-24 | Johnson T. Wong | Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy |
| GB9815909D0 (en) | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
| US7678836B2 (en) * | 1999-11-04 | 2010-03-16 | Fxs Ventures, Llc | Method for rendering a contact lens wettable |
| US8557868B2 (en) * | 2000-11-04 | 2013-10-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions using low molecular weight amines |
| US20070104744A1 (en) * | 2000-11-08 | 2007-05-10 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing forms of vitamin b |
| US20060148665A1 (en) * | 2000-11-08 | 2006-07-06 | Bioconcept Laboratories | Ophthalmic and contact lens solutions containing forms of vitamin b |
| CN1245166C (zh) | 2000-11-08 | 2006-03-15 | 生物概念实验室 | 改进的含有单糖类作为防腐增强剂的眼科和隐形眼镜用溶液 |
| US9308264B2 (en) | 2000-11-08 | 2016-04-12 | Fxs Ventures, Llc | Ophthalmic contact lens solutions containing forms of vitamin B |
| US20060127496A1 (en) * | 2000-11-08 | 2006-06-15 | Bioconcept Laboratories | L-histidine in ophthalmic solutions |
| JP2004525865A (ja) * | 2000-11-08 | 2004-08-26 | バイオ−コンセプト・ラボラトリーズ | 過酸化物源およびカチオン性ポリマー防腐剤を含有する改良した眼科用およびコンタクトレンズ用溶液 |
| US9492582B2 (en) * | 2000-11-08 | 2016-11-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US20070110782A1 (en) * | 2000-11-08 | 2007-05-17 | Fxs Ventures, Llc | L-histidine in ophthalmic solutions |
| WO2004091438A2 (en) * | 2003-04-15 | 2004-10-28 | Fxs Ventures, Llc | Improved ophthalmic and contact lens solutions containing peptides as representative enhancers |
| NZ546173A (en) * | 2003-10-16 | 2009-04-30 | Micromet Ag | Multispecific deimmunized CD3-binders |
| EP1687066B1 (en) * | 2003-11-14 | 2012-08-29 | Brigham and Women's Hospital, Inc. | Methods of modulating immunity |
| CA2614640A1 (en) * | 2005-07-11 | 2007-01-18 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| SG177907A1 (en) * | 2006-06-14 | 2012-02-28 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| WO2008079713A2 (en) * | 2006-12-21 | 2008-07-03 | Macrogenics Inc. | Methods for the treatment of lada and other adult-onset autoimmune diabetes using immunosuppressive monoclonal antibodies with reduced toxicity |
| SG10201700096VA (en) | 2009-07-17 | 2017-02-27 | Bioatla Llc | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts |
| US20130078238A1 (en) | 2010-04-29 | 2013-03-28 | Hadasit Medical Research Services & Decvelopment Co. Ltd. | Methods and Compositions for Treating Hepatitis with Anti-CD3 Immune Molecule Therapy |
| ES2966088T3 (es) | 2010-07-16 | 2024-04-18 | Bioatla Inc | Nuevos métodos de evolución de proteínas |
| US20130273055A1 (en) | 2010-11-16 | 2013-10-17 | Eric Borges | Agents and methods for treating diseases that correlate with bcma expression |
| EP2659270A4 (en) | 2010-12-31 | 2014-05-21 | Bioatla Llc | GENERATION OF WHOLE MONOCLONAL ANTIBODIES |
| EP2658970B1 (en) | 2010-12-31 | 2016-09-28 | Bioatla LLC | Express humanization of antibodies |
| KR102023401B1 (ko) | 2012-05-10 | 2019-11-04 | 바이오아트라, 엘엘씨 | 다중-특이적 모노클로날 항체 |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| EP3447493B1 (en) | 2014-01-07 | 2020-05-13 | Bioatla, LLC | Proteins targeting orthologs |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| MY184699A (en) | 2014-04-16 | 2021-04-18 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| EP3172235A2 (en) | 2014-07-25 | 2017-05-31 | Cytomx Therapeutics Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
| KR102614189B1 (ko) | 2014-11-17 | 2023-12-18 | 리제너론 파아마슈티컬스, 인크. | Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법 |
| CN107428835B (zh) | 2015-01-23 | 2021-11-26 | 赛诺菲 | 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体 |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| JP7195141B2 (ja) | 2015-10-22 | 2022-12-23 | ジュノ セラピューティクス ゲーエムベーハー | 形質導入のための方法、キット、作用物質および装置 |
| CA3003969A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
| EP4059957A1 (en) | 2016-02-05 | 2022-09-21 | Orionis Biosciences BV | Bispecific signaling agents and uses thereof |
| TWI790206B (zh) | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白 |
| WO2018144999A1 (en) | 2017-02-06 | 2018-08-09 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| NZ758485A (en) | 2017-04-27 | 2024-02-23 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| JP2022512913A (ja) | 2018-11-06 | 2022-02-07 | ジュノー セラピューティクス インコーポレイテッド | 遺伝子操作されたｔ細胞を作製するための方法 |
| US20220348660A1 (en) | 2019-10-02 | 2022-11-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of adult t-cell leukemia/lymphoma |
| AU2020377043A1 (en) | 2019-10-30 | 2022-06-02 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| CN115768443A (zh) | 2020-02-12 | 2023-03-07 | 朱诺治疗学股份有限公司 | Cd19定向嵌合抗原受体t细胞组合物和方法及其用途 |
| BR112022015968A2 (pt) | 2020-02-12 | 2022-10-11 | Juno Therapeutics Inc | Composições de células t do receptor de antígeno quimérico direcionado a bcma e métodos e usos das mesmas |
| US20210284743A1 (en) | 2020-03-10 | 2021-09-16 | Tiziana Life Sciences Plc | Compositions of il-6/il-6r antibodies and methods of use thereof |
| WO2021231661A2 (en) | 2020-05-13 | 2021-11-18 | Juno Therapeutics, Inc. | Process for producing donor-batched cells expressing a recombinant receptor |
| CN115768878A (zh) | 2020-06-17 | 2023-03-07 | 迪赞纳生命科学公开有限公司 | 用于增强嵌合抗原受体(car) t细胞疗法的组合物和方法 |
| EP4188440A2 (en) | 2020-07-30 | 2023-06-07 | Tiziana Life Sciences PLC | Cd-3 antibodies for the treatment of coronavirus |
| EP4323404A1 (en) | 2021-04-16 | 2024-02-21 | Tiziana Life Sciences PLC | Subcutaneous administration of antibodies for the treatment of disease |
| CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
| WO2023064942A1 (en) | 2021-10-14 | 2023-04-20 | Tiziana Life Sciences Plc | Methods of suppressing microglial activation |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023147331A1 (en) | 2022-01-26 | 2023-08-03 | Mabswitch Inc. | Bispecific molecule with tunable affinity to a targetted antigen |
| WO2023147510A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Chromatography arrays and related methods and kits |
| WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR956062A (US06623731-20030923-C00012.png) * | 1950-01-24 | |||
| GB824492A (en) * | 1955-10-07 | 1959-12-02 | Frederick William Beinlich | Process and apparatus for the generation of power |
| US3988895A (en) * | 1974-01-11 | 1976-11-02 | Itzhak Sheinbaum | Power generation from hot brines |
| US3986362A (en) * | 1975-06-13 | 1976-10-19 | Petru Baciu | Geothermal power plant with intermediate superheating and simultaneous generation of thermal and electrical energy |
| US4089175A (en) * | 1975-06-23 | 1978-05-16 | Occidental Petroleum Corporation | Process and system for recovery of energy from geothermal brines and other water containing sources by direct contact with a working fluid below the critical pressure |
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| BE875277A (fr) * | 1979-04-02 | 1979-10-02 | Jourdain Leon J | Machine motrice |
| US4284412A (en) * | 1979-07-13 | 1981-08-18 | Ortho Diagnostics, Inc. | Method and apparatus for automated identification and enumeration of specified blood cell subclasses |
-
1979
- 1979-04-26 US US06/033,669 patent/US4361549A/en not_active Expired - Lifetime
-
1980
- 1980-04-01 CA CA000348978A patent/CA1182406A/en not_active Expired
- 1980-04-17 NZ NZ193469A patent/NZ193469A/en unknown
- 1980-04-24 JP JP5369180A patent/JPS55145617A/ja active Granted
- 1980-04-24 PT PT71147A patent/PT71147B/pt active IP Right Revival
- 1980-04-24 AU AU57757/80A patent/AU544791B2/en not_active Expired
- 1980-04-24 IL IL59917A patent/IL59917A/xx unknown
- 1980-04-25 EP EP80301357A patent/EP0018795B2/en not_active Expired - Lifetime
- 1980-04-25 NO NO801214A patent/NO159221C/no unknown
- 1980-04-25 DE DE198080301357T patent/DE18795T1/de active Pending
- 1980-04-25 DK DK180380A patent/DK154769C/da not_active IP Right Cessation
- 1980-04-25 DE DE8080301357T patent/DE3070803D1/de not_active Expired
- 1980-04-25 ZA ZA00802525A patent/ZA802525B/xx unknown
- 1980-04-25 IE IE840/80A patent/IE50422B1/en not_active IP Right Cessation
- 1980-04-25 ES ES490944A patent/ES8105152A1/es not_active Expired
- 1980-04-25 FI FI801342A patent/FI75183C/fi not_active IP Right Cessation
- 1980-04-25 PH PH23955A patent/PH16642A/en unknown
- 1980-04-25 AT AT80301357T patent/ATE14023T1/de not_active IP Right Cessation
- 1980-04-25 YU YU114680A patent/YU48442B/sh unknown
-
1986
- 1986-01-21 SG SG66/86A patent/SG6686G/en unknown
- 1986-04-03 HK HK238/86A patent/HK23886A/xx not_active IP Right Cessation
- 1986-12-30 MY MY514/86A patent/MY8600514A/xx unknown
-
1988
- 1988-04-26 JP JP63101498A patent/JPH0198478A/ja active Granted
-
1993
- 1993-07-02 NL NL930131C patent/NL930131I2/nl unknown
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