NO992107L - FremgangsmÕte for pÕvisning av forbindelser som modulerer effekten av fett (OB) proteinet - Google Patents

FremgangsmÕte for pÕvisning av forbindelser som modulerer effekten av fett (OB) proteinet

Info

Publication number
NO992107L
NO992107L NO992107A NO992107A NO992107L NO 992107 L NO992107 L NO 992107L NO 992107 A NO992107 A NO 992107A NO 992107 A NO992107 A NO 992107A NO 992107 L NO992107 L NO 992107L
Authority
NO
Norway
Prior art keywords
cell line
protein
derived cell
compound
response element
Prior art date
Application number
NO992107A
Other languages
English (en)
Other versions
NO992107D0 (no
Inventor
Lee James Beeley
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9622850.7A external-priority patent/GB9622850D0/en
Priority claimed from GBGB9622865.5A external-priority patent/GB9622865D0/en
Priority claimed from GBGB9622849.9A external-priority patent/GB9622849D0/en
Priority claimed from GBGB9622870.5A external-priority patent/GB9622870D0/en
Priority claimed from GBGB9622851.5A external-priority patent/GB9622851D0/en
Priority claimed from GBGB9622866.3A external-priority patent/GB9622866D0/en
Priority claimed from GBGB9622847.3A external-priority patent/GB9622847D0/en
Priority claimed from GBGB9622848.1A external-priority patent/GB9622848D0/en
Priority claimed from GBGB9622868.9A external-priority patent/GB9622868D0/en
Priority claimed from GBGB9622869.7A external-priority patent/GB9622869D0/en
Priority claimed from GBGB9622867.1A external-priority patent/GB9622867D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO992107D0 publication Critical patent/NO992107D0/no
Publication of NO992107L publication Critical patent/NO992107L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/5759Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Det beskrives en fremgangsmåte for påvisning av en forbindelse som etterligner, potensierer eller inhiberer den fysiologiske effekt av ob-proteinet, og som omfatter: (a) for en forbindelse som etterligner den fysiologiske effekt av ob- proteinet, bestemmelse av effekten av forbindelsen på et ob-proteinaktivert STAT- DNA responselement koblet til et rapportørgen (STAT = signaltransducer og aktivator av transkripsjon; eller (b) for en forbindelse som potensierer eller inhiberer den fysiologiske effekt av ob-proteinet, bestemmelse av effekten av forbindelsen på den respons som gis av ob-protein på et ob-proteinaktivert STAT DNA- responselement koblet til et rapportørgen; hvor responselementet og rapportøren uttrykkes i en ob-proteinresponderende cellelinje, hvor cellelinjen er valgt fra følgende liste: en hypothalamus-avledet cellelinje; en feokromocytom-avledet cellelinje; en hematopoetisk avledet cellelinje; en pankreatisk avledet cellelinje; en lever-avledet cellelinje; en preadipocytt-avledet cellelinje; en skjelettmuskel-avledet cellelinje; og en ovarie-avledet cellelinje; eller responselementet og rapportøren uttrykkes i en cellelinje, hvor cellelinjen (den manipulerte cellelinje) også transfekteres med et polypeptid som er i stand til å mediere stimuleringen av ob-protein av et ob- proteinaktivert STAT DNA-responselement og inneholder de passende STAT- proteinene.
NO992107A 1996-11-01 1999-04-30 FremgangsmÕte for pÕvisning av forbindelser som modulerer effekten av fett (OB) proteinet NO992107L (no)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GBGB9622870.5A GB9622870D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622851.5A GB9622851D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622866.3A GB9622866D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622850.7A GB9622850D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622867.1A GB9622867D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622865.5A GB9622865D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622869.7A GB9622869D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622868.9A GB9622868D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622848.1A GB9622848D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622847.3A GB9622847D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622849.9A GB9622849D0 (en) 1996-11-01 1996-11-01 Novel method
PCT/GB1997/002988 WO1998020158A1 (en) 1996-11-01 1997-10-30 Method for the detection of compounds that modulate the effects of the obese (ob) protein

Publications (2)

Publication Number Publication Date
NO992107D0 NO992107D0 (no) 1999-04-30
NO992107L true NO992107L (no) 1999-06-30

Family

ID=27581686

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992107A NO992107L (no) 1996-11-01 1999-04-30 FremgangsmÕte for pÕvisning av forbindelser som modulerer effekten av fett (OB) proteinet

Country Status (13)

Country Link
EP (1) EP0951564A1 (no)
JP (1) JP2001503982A (no)
KR (1) KR20000053007A (no)
AR (1) AR010262A1 (no)
AU (1) AU4789297A (no)
CA (1) CA2270431A1 (no)
CZ (1) CZ149999A3 (no)
IL (1) IL129685A0 (no)
NO (1) NO992107L (no)
NZ (1) NZ335489A (no)
PL (1) PL333187A1 (no)
TR (1) TR199900963T2 (no)
WO (1) WO1998020158A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293533B1 (it) * 1997-07-14 1999-03-01 Angeletti P Ist Richerche Bio Metodo per la selezione di molecole in grado di mimare, inibire o potenziare gli effetti della interazione tra leptina e cellule che
GB9814199D0 (en) * 1998-06-30 1998-08-26 Univ Buckingham Novel method
AU756617B2 (en) 1998-07-28 2003-01-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Leptin-mediated gene-induction
GB9828087D0 (en) * 1998-12-18 1999-02-17 Smithkline Beecham Plc Novel method
DE60112282T2 (de) 2000-05-22 2006-04-20 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Auf rezeptorgrundlage arbeitende screening-verfahren für protein wechselwirkungen
GB0019327D0 (en) * 2000-08-08 2000-09-27 Buchanan Baillie Hamilton Paul Slimming system
CA2585549A1 (en) 2004-11-18 2006-05-26 Vib Vzw Novel type leptin receptor antagonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643748A (en) * 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
US6068976A (en) * 1995-03-20 2000-05-30 Ligand Pharmaceuticals Incorporated Modulators of ob gene and screening methods therefor
US5712094A (en) * 1995-03-27 1998-01-27 Ligand Pharmaceuticals, Inc. Methods for detecting modulators of cytokine action
TR199701469T1 (xx) * 1995-05-30 1998-03-21 Smithkline Beecham P.L.C �i�man (OB) proteinin etkilerini de�i�tiren bile�imlerin meydana ��kar�lmas� i�in y�ntem.
WO1997040380A1 (en) * 1996-04-22 1997-10-30 Merck & Co., Inc. Leptin assay

Also Published As

Publication number Publication date
TR199900963T2 (xx) 1999-08-23
PL333187A1 (en) 1999-11-22
EP0951564A1 (en) 1999-10-27
KR20000053007A (ko) 2000-08-25
AR010262A1 (es) 2000-06-07
JP2001503982A (ja) 2001-03-27
IL129685A0 (en) 2000-02-29
AU4789297A (en) 1998-05-29
CA2270431A1 (en) 1998-05-14
WO1998020158A1 (en) 1998-05-14
NZ335489A (en) 2001-01-26
CZ149999A3 (cs) 1999-10-13
NO992107D0 (no) 1999-04-30

Similar Documents

Publication Publication Date Title
Iontcheva et al. Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins
MX9606404A (es) Composiciones farmaceuticas y metodos para formular trasnduccion de señales.
NO962991D0 (no) Zink-finger-proteinderivater og fremgangsmåter
NO166303C (no) Fremgangsmaate ved kvantitativ bestemmelse av protein c ogaktivatorpreparat til gjennomfoering av fremgangsmaaten.
DE3779706D1 (de) Enzymsensor zur bestimmung von glutaminat-konzentration.
ATE245699T1 (de) Rekombinant pgp3, verfahren zu dessen herstellung,und dessen verwendung in der diagnose und therapie
NO992107L (no) FremgangsmÕte for pÕvisning av forbindelser som modulerer effekten av fett (OB) proteinet
NO165966C (no) Fremgangsmaate for utvinning av chitin fra materialer hvorchitin opptrer sammen med, eller i tilknytning til, proteinsubstanser.
Ueno et al. Identification of storage protein receptor and its precursor in the fat body membrane of Sarcophaga peregrina.
NO975504L (no) Fremgangsmåte for påvisning av forbindelser som modulerer virkningene av fettproteinet
Kristjansson Genetic control of two blood serum proteins in swine
ATE373083T1 (de) Methode und zusammensetzungen zur identifizierung von morphogen-analogen
DE69638341D1 (de) Anzeigeprozessorsystem für eine punktorganisierte Anzeige von Wellenformdaten
AU2172597A (en) Protein phosphatase-1 catalytic subunit interactions
DE69316388D1 (de) CRF Bindungsproteine
ATE309270T1 (de) ßSMOOTHENEDß PROTEINE AUS WIRBELTIEREN
DK0788512T3 (da) Proinsulinpeptidforbindelser til detektion og behandling af Type I-diabetes
Kontani et al. Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis
ATE148744T1 (de) Neue thrombininhibitorische proteine aus landblutegeln
HUP0000034A2 (hu) Eljárás az elhízási (ob) protein hatásait moduláló vegyületek kimutatására
DeLange et al. The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. I. The tryptic peptides from the maleylated protein.
NO20006541L (no) Fremgangsmåte for påvisning av en forbindelse som etterligner, potensierer eller inhiberer den fysiologiske effekten av leptin
FR2509139B1 (fr) Isolement de proteine microbienne d'une teneur reduite en acides nucleiques
Tate et al. Isolation and identification of two learning-induced brain peptides
RU95102036A (ru) Способ определения спонтанной двигательной активности крыс

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application