NO990671L - Muskarinantagonistiske etere - Google Patents
Muskarinantagonistiske etereInfo
- Publication number
- NO990671L NO990671L NO990671A NO990671A NO990671L NO 990671 L NO990671 L NO 990671L NO 990671 A NO990671 A NO 990671A NO 990671 A NO990671 A NO 990671A NO 990671 L NO990671 L NO 990671L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- formula
- alkyl
- compounds
- cycloalkyl
- Prior art date
Links
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 150000002170 ethers Chemical class 0.000 title 1
- -1 1,4-Disubstituted piperidine Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003149 muscarinic antagonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70072296A | 1996-08-15 | 1996-08-15 | |
| PCT/US1997/013894 WO1998006697A1 (en) | 1996-08-15 | 1997-08-13 | Ether muscarinic antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO990671D0 NO990671D0 (no) | 1999-02-12 |
| NO990671L true NO990671L (no) | 1999-04-15 |
Family
ID=24814614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO990671A NO990671L (no) | 1996-08-15 | 1999-02-12 | Muskarinantagonistiske etere |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0922029B1 (de) |
| JP (1) | JP3390179B2 (de) |
| KR (1) | KR20000029976A (de) |
| CN (1) | CN1155574C (de) |
| AT (1) | ATE297381T1 (de) |
| AU (1) | AU732096B2 (de) |
| BR (1) | BR9711061A (de) |
| CA (1) | CA2263167C (de) |
| CZ (1) | CZ43399A3 (de) |
| DE (1) | DE69733478T2 (de) |
| ES (1) | ES2241053T3 (de) |
| HU (1) | HUP9904363A3 (de) |
| IL (1) | IL128524A0 (de) |
| NO (1) | NO990671L (de) |
| NZ (1) | NZ334017A (de) |
| PL (1) | PL331536A1 (de) |
| SK (1) | SK20199A3 (de) |
| TR (1) | TR199900314T2 (de) |
| WO (1) | WO1998006697A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002509918A (ja) * | 1998-03-31 | 2002-04-02 | アケイディア ファーマスーティカルズ インコーポレイテッド | ムスカリン性レセプタに活性を有する化合物 |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| EP1140061B1 (de) | 1998-12-23 | 2003-05-02 | Orphan Medical Inc. | Mikrobenbeständige und stabilisierte lösungen, die gamma-hydroxybuttersäuresalze zur behandlung von narkolepsie enthalten |
| US6635646B1 (en) | 1999-05-04 | 2003-10-21 | Schering Corporation | Pegylated interferon alfa-CCR5 antagonist combination HIV therapy |
| ATE299866T1 (de) * | 1999-05-04 | 2005-08-15 | Schering Corp | Piperidinderivate verwendbar als ccr5 antagonisten |
| US6387930B1 (en) | 1999-05-04 | 2002-05-14 | Schering Corporation | Piperidine derivatives useful as CCR5 antagonists |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| US7718650B2 (en) | 2001-05-11 | 2010-05-18 | Biovitrum Ab | Aryl sulfonamide compounds for treating obesity |
| PL366619A1 (en) | 2001-05-11 | 2005-02-07 | Biovitrum Ab | Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders |
| ES2258642T3 (es) | 2001-07-02 | 2006-09-01 | Astrazeneca Ab | Derivados de piperidina utiles como moduladores de la actividad del receptor de quimiocina. |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| KR100579813B1 (ko) * | 2001-10-16 | 2006-05-12 | 주식회사 에스티씨나라 | 피페리딘 유도체, 이의 제조방법 및 이를 포함하는 치매치료용 약학적 조성물 |
| DE10201550A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| BRPI0311780B8 (pt) | 2002-06-14 | 2021-05-25 | Toyama Chemical Co Ltd | composição farmacêutica para melhorar a função cerebral |
| SE0202838D0 (sv) * | 2002-09-24 | 2002-09-24 | Astrazeneca Ab | Chemical compounds |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| SE0302956D0 (sv) * | 2003-11-07 | 2003-11-07 | Astrazeneca Ab | Chemical compounds |
| TW200722419A (en) * | 2005-05-27 | 2007-06-16 | Astrazeneca Ab | Chemical compounds |
| US20080200505A1 (en) * | 2005-05-27 | 2008-08-21 | Astrazeneca Ab | Piperidines for the Treatment of Chemokine Mediated Diseases |
| EP2402316A1 (de) | 2005-07-21 | 2012-01-04 | AstraZeneca AB (Publ) | Piperidinderivate |
| DE102008008838A1 (de) | 2008-02-13 | 2009-08-20 | Bayer Healthcare Ag | Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| CN102762554A (zh) | 2010-02-16 | 2012-10-31 | 辉瑞大药厂 | 5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇 |
| CR20180443A (es) | 2016-03-17 | 2018-11-21 | Hoffmann La Roche | Derivado de morfolina |
| WO2018112843A1 (en) * | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112840A1 (en) * | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6, 5-fused heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| JP3064425B2 (ja) * | 1995-09-15 | 2000-07-12 | ノイロサーチ アクティーゼルスカブ | カルシウムチャンネル・ブロッカーとしてのピペリジン化合物 |
-
1997
- 1997-08-13 PL PL97331536A patent/PL331536A1/xx unknown
- 1997-08-13 NZ NZ334017A patent/NZ334017A/xx unknown
- 1997-08-13 BR BR9711061A patent/BR9711061A/pt unknown
- 1997-08-13 AT AT97937152T patent/ATE297381T1/de not_active IP Right Cessation
- 1997-08-13 CN CNB971985588A patent/CN1155574C/zh not_active Expired - Fee Related
- 1997-08-13 AU AU39732/97A patent/AU732096B2/en not_active Ceased
- 1997-08-13 SK SK201-99A patent/SK20199A3/sk unknown
- 1997-08-13 CZ CZ99433A patent/CZ43399A3/cs unknown
- 1997-08-13 CA CA002263167A patent/CA2263167C/en not_active Expired - Fee Related
- 1997-08-13 WO PCT/US1997/013894 patent/WO1998006697A1/en active IP Right Grant
- 1997-08-13 ES ES97937152T patent/ES2241053T3/es not_active Expired - Lifetime
- 1997-08-13 EP EP97937152A patent/EP0922029B1/de not_active Expired - Lifetime
- 1997-08-13 JP JP50985498A patent/JP3390179B2/ja not_active Expired - Fee Related
- 1997-08-13 KR KR1019997001227A patent/KR20000029976A/ko not_active Application Discontinuation
- 1997-08-13 DE DE69733478T patent/DE69733478T2/de not_active Expired - Fee Related
- 1997-08-13 IL IL12852497A patent/IL128524A0/xx unknown
- 1997-08-13 HU HU9904363A patent/HUP9904363A3/hu unknown
- 1997-08-13 TR TR1999/00314T patent/TR199900314T2/xx unknown
-
1999
- 1999-02-12 NO NO990671A patent/NO990671L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9904363A2 (hu) | 2000-11-28 |
| AU3973297A (en) | 1998-03-06 |
| WO1998006697A1 (en) | 1998-02-19 |
| CA2263167A1 (en) | 1998-02-19 |
| TR199900314T2 (xx) | 1999-05-21 |
| BR9711061A (pt) | 1999-08-17 |
| PL331536A1 (en) | 1999-07-19 |
| JP2000500786A (ja) | 2000-01-25 |
| SK20199A3 (en) | 2000-03-13 |
| EP0922029B1 (de) | 2005-06-08 |
| DE69733478D1 (de) | 2005-07-14 |
| NZ334017A (en) | 2000-04-28 |
| JP3390179B2 (ja) | 2003-03-24 |
| ATE297381T1 (de) | 2005-06-15 |
| CN1232453A (zh) | 1999-10-20 |
| ES2241053T3 (es) | 2005-10-16 |
| AU732096B2 (en) | 2001-04-12 |
| HUP9904363A3 (en) | 2000-12-28 |
| EP0922029A1 (de) | 1999-06-16 |
| DE69733478T2 (de) | 2005-11-03 |
| CZ43399A3 (cs) | 1999-07-14 |
| CN1155574C (zh) | 2004-06-30 |
| CA2263167C (en) | 2006-02-14 |
| NO990671D0 (no) | 1999-02-12 |
| IL128524A0 (en) | 2000-01-31 |
| KR20000029976A (ko) | 2000-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |