NO985820L - Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse - Google Patents
Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disseInfo
- Publication number
- NO985820L NO985820L NO985820A NO985820A NO985820L NO 985820 L NO985820 L NO 985820L NO 985820 A NO985820 A NO 985820A NO 985820 A NO985820 A NO 985820A NO 985820 L NO985820 L NO 985820L
- Authority
- NO
- Norway
- Prior art keywords
- cytokine production
- heteroaryl
- aryl
- formula
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Det er beskrevet en cytokinproduksjonsinhibitor omfattende en forbindelse med formel (O N B [U hvor R1 er aryl eller heteroaryl; B er en gruppe med formel (a) eller (b) N ¿ C¿ R / (aj /V2 hvor R2 er hydrogenatom, hydroksy, halogenatom og lignende; R4 er hydrogenatom eller halogenatom, eller R2 og R4 i kombinasjon danner karbonyl; R3 er lavere alkoksy, cykloalkyl, aryl, heteroaryl, -X-Y og lignende, hvor X er -(CH2)m-, -CO-, -COCH2-, -NHCHr, -CH2NH-, -OCH2- og lignende; Y er halogenatom, cykloalkyl, aryl eller hete- roaryl; R51 er -NHCONHR57 og lignende; R52 er hydrogenatom eller -COOR53; A er benzenring eller tiofenring, ny triazepinforbindelse og mellomprodukter for fremstilling av disse triazepinforbindelsene. Forbindelser med formel (I) undertrykker produksjonen av cytokin så som IL-6, TNF-ct, IL-8, IFNy, IL-2, GM-CSF og lignende, og er nyttig som cytokinproduksjonsinhibitorer eller antiinflammatoriske medikamenter.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17426896 | 1996-06-12 | ||
JP9523797 | 1997-03-28 | ||
PCT/JP1997/002016 WO1997047622A1 (fr) | 1996-06-12 | 1997-06-11 | Inhibiteurs de production de cytokines, composes triazepine et intermediaires correspondants |
Publications (2)
Publication Number | Publication Date |
---|---|
NO985820D0 NO985820D0 (no) | 1998-12-11 |
NO985820L true NO985820L (no) | 1999-02-01 |
Family
ID=26436510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO985820A NO985820L (no) | 1996-06-12 | 1998-12-11 | Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0934940A1 (no) |
CN (1) | CN1227555A (no) |
AU (1) | AU3106197A (no) |
BR (1) | BR9710453A (no) |
CA (1) | CA2258053A1 (no) |
IL (1) | IL127516A0 (no) |
NO (1) | NO985820L (no) |
PL (1) | PL330635A1 (no) |
WO (1) | WO1997047622A1 (no) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4071636B2 (ja) * | 2001-04-03 | 2008-04-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シクロオクタノン誘導体およびシクロデカノン誘導体、およびその用途 |
US20070238677A1 (en) * | 2004-03-17 | 2007-10-11 | Locomogene, Inc. | Pharmaceutical Composition Containing Hshrd3 |
GB0919426D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
WO2011054851A1 (en) | 2009-11-05 | 2011-05-12 | Glaxosmithkline Llc | Novel process |
ES2564318T3 (es) * | 2009-11-05 | 2016-03-21 | Glaxosmithkline Llc | Inhibidor de bromodominio de benzodiazepina |
AU2010314395B2 (en) * | 2009-11-05 | 2015-04-09 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
AU2015203454B2 (en) * | 2009-11-05 | 2017-02-23 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
HUE031073T2 (en) * | 2010-05-14 | 2017-06-28 | Dana Farber Cancer Inst Inc | Thieno triazolo-diazepine compounds for the treatment of neoplasia |
US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
JP5715241B2 (ja) * | 2010-05-14 | 2015-05-07 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 |
AU2015201727B2 (en) * | 2010-05-14 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
EP2569434B1 (en) | 2010-05-14 | 2019-09-04 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia and related disorders |
ES2526671T3 (es) | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
TWI549955B (zh) * | 2010-08-04 | 2016-09-21 | 達納 法柏癌症學院有限公司 | 治療腫瘤形成、發炎疾病及其他病症之組成物及方法 |
AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
DE102011082013A1 (de) | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
CN102603743B (zh) * | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
CA2881996A1 (en) | 2012-08-16 | 2014-02-20 | Bayer Pharma Aktiengesellschaft | 2,3-benzodiazepines |
ES2625959T3 (es) | 2012-09-28 | 2017-07-21 | Bayer Pharma Aktiengesellschaft | 5-Aril-triazolo-azepinas inhibidoras de la proteína BET |
KR20160034379A (ko) | 2013-07-25 | 2016-03-29 | 다나-파버 캔서 인스티튜트 인크. | 전사 인자의 억제제 및 그의 용도 |
WO2015070020A2 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
AU2015222805B2 (en) | 2014-02-28 | 2020-05-21 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
EP3157928B1 (en) | 2014-06-20 | 2019-02-13 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
CA2955077A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
BR112017006342A2 (pt) * | 2014-10-02 | 2017-12-19 | Glaxosmithkline Ip No 2 Ltd | composto de sal de ácido benzenossulfônico, forma em estado sólido cristalino, composição farmacêutica, produto farmacêutico de combinação, método de tratamento de doenças ou condições, uso de um composto de sal de ácido benzenossulfônico, e, processo para preparação de um composto de sal de ácido benzenossulfônico. |
BR112017008714A2 (pt) | 2014-10-27 | 2017-12-19 | Tensha Therapeutics Inc | inibidores de bromodomínio |
AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
PE20181086A1 (es) | 2015-09-11 | 2018-07-05 | Dana Farber Cancer Inst Inc | Acetamida tienotrizolodiazepinas y usos de las mismas |
WO2017044849A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
EP3518898A4 (en) * | 2016-10-03 | 2020-06-17 | The Children's Medical Center Corporation | PREVENTION AND TREATMENT OF DIABETIC NEPHROPATHY |
CA3064845A1 (en) | 2017-05-31 | 2018-12-06 | Ayumi Pharmaceutical Corporation | 6h-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives |
KR20210020889A (ko) * | 2018-06-13 | 2021-02-24 | 디블라이 아게 | 응축된 트리아제핀 유도체의 제조 및 이의 bet 억제제로서 용도 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1489979A (en) * | 1975-01-20 | 1977-10-26 | Upjohn Co | Triazolo benzo-diazepines and triazolo benzodiazocines |
US4144233A (en) * | 1977-02-16 | 1979-03-13 | The Dow Chemical Company | Method for preparing benzo-(1,3,4)-benzotriazepines |
JP2622673B2 (ja) * | 1994-11-18 | 1997-06-18 | 日本たばこ産業株式会社 | 骨粗鬆症治療薬およびトリアゼピン化合物 |
CA2205173A1 (en) * | 1994-11-18 | 1996-05-30 | Takeshi Nakamura | Therapeutic agent for osteoporosis and triazepine compound |
-
1997
- 1997-06-11 EP EP97926224A patent/EP0934940A1/en not_active Withdrawn
- 1997-06-11 IL IL12751697A patent/IL127516A0/xx unknown
- 1997-06-11 WO PCT/JP1997/002016 patent/WO1997047622A1/ja not_active Application Discontinuation
- 1997-06-11 BR BR9710453A patent/BR9710453A/pt unknown
- 1997-06-11 CN CN97197090.4A patent/CN1227555A/zh active Pending
- 1997-06-11 AU AU31061/97A patent/AU3106197A/en not_active Abandoned
- 1997-06-11 PL PL97330635A patent/PL330635A1/xx unknown
- 1997-06-11 CA CA002258053A patent/CA2258053A1/en not_active Abandoned
-
1998
- 1998-12-11 NO NO985820A patent/NO985820L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1227555A (zh) | 1999-09-01 |
NO985820D0 (no) | 1998-12-11 |
EP0934940A1 (en) | 1999-08-11 |
IL127516A0 (en) | 1999-10-28 |
BR9710453A (pt) | 1999-08-17 |
PL330635A1 (en) | 1999-05-24 |
WO1997047622A1 (fr) | 1997-12-18 |
AU3106197A (en) | 1998-01-07 |
CA2258053A1 (en) | 1997-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO985820L (no) | Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse | |
DK135791A (da) | 1h-imidazooe4,5-caaquinolin-4-amin, farmaceutisk praeparat indeholdende en saadan forbindelse og fremga ngsmaade til fremstilling af forbindelsen | |
DE69903976T2 (de) | Heteroaryl-zyklische acetale | |
FI935672A0 (fi) | Substituerade pyrazoler | |
DK633088A (da) | Kollagenaseinhibitorer | |
PL307090A1 (en) | Derivatives of o-benzyl oxime ether and their application as pesticides | |
NO986180L (no) | Nye amidinoderivater og deres anvendelse som trombininhibitorer | |
EP1468990A4 (en) | piperazine derivative | |
NZ333957A (en) | Compounds able to displace tritiated cis-N-cyclohexyl-N-ethyl[3-(3-chloro-4-cyclohexyphenyl)-allyl]amine | |
MXPA04002570A (es) | Compuestos que inhiben la liberacion de citocinas inflamatorias. | |
EA200100090A2 (ru) | Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции | |
ES2154605A1 (es) | Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3 | |
ES2106936T3 (es) | Derivados de carbazolona y procedimientos para su preparacion. | |
DK0763024T3 (da) | Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater | |
NZ227400A (en) | Thiol-ketone and thiol-aldehyde derivatives, intermediates thereof and pharmaceutical compositions | |
HRP20020440B1 (en) | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | |
DE3687385D1 (de) | 2-substituierte-1,4-dihydropyridine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
FI834410A0 (fi) | Foerfarande foer framstaellning av pyrimidinonderivat | |
DK67582A (da) | Fremgangsmaade til fremstilling af aroylimidazol-2-oner | |
CA2203850A1 (en) | Novel n-phenyl-n-phenyliminonethylbenzamidines and their analogues as muscarinic receptor agonists | |
ATE201412T1 (de) | Pteridinderivate als no synthase-hemmer | |
IT1255207B (it) | Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatrice | |
NO20023513L (no) | Anvendelse av et ekstraheringsmiddel som et antiskummiddel ved fremstilling av vannfri maursyre | |
DE3560829D1 (de) | Enkephalinase inhibitors | |
KR20000016732A (en) | Cytokine production inhibitors, triazepine compounds, and intermediates thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |