NO984761L - Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler - Google Patents

Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler

Info

Publication number
NO984761L
NO984761L NO984761A NO984761A NO984761L NO 984761 L NO984761 L NO 984761L NO 984761 A NO984761 A NO 984761A NO 984761 A NO984761 A NO 984761A NO 984761 L NO984761 L NO 984761L
Authority
NO
Norway
Prior art keywords
alkyl
halogen
alkoxy
optionally substituted
hydrogen
Prior art date
Application number
NO984761A
Other languages
English (en)
Norwegian (no)
Other versions
NO984761D0 (no
Inventor
Peter Hamley
James Mcdonald
James Matz
Alan Tinker
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607717.7A external-priority patent/GB9607717D0/en
Priority claimed from GBGB9608678.0A external-priority patent/GB9608678D0/en
Priority claimed from GBGB9610892.3A external-priority patent/GB9610892D0/en
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Publication of NO984761D0 publication Critical patent/NO984761D0/no
Publication of NO984761L publication Critical patent/NO984761L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO984761A 1996-04-13 1998-10-12 Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler NO984761L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9607717.7A GB9607717D0 (en) 1996-04-13 1996-04-13 Pharmaceutically active comounds
GBGB9608678.0A GB9608678D0 (en) 1996-04-26 1996-04-26 Pharmaceuticlly active compounds
GBGB9610892.3A GB9610892D0 (en) 1996-05-24 1996-05-24 Pharmaceutically active compounds
PCT/SE1997/000589 WO1997038977A1 (en) 1996-04-13 1997-04-09 Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
NO984761D0 NO984761D0 (no) 1998-10-12
NO984761L true NO984761L (no) 1998-12-14

Family

ID=27268241

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984761A NO984761L (no) 1996-04-13 1998-10-12 Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler

Country Status (21)

Country Link
US (1) US6063789A (xx)
EP (1) EP0892784A1 (xx)
JP (1) JP2000509028A (xx)
KR (1) KR20000005388A (xx)
CN (1) CN1221407A (xx)
AR (1) AR006619A1 (xx)
AU (1) AU706110B2 (xx)
BR (1) BR9708607A (xx)
CA (1) CA2251681A1 (xx)
CZ (1) CZ327698A3 (xx)
EE (1) EE9800339A (xx)
HU (1) HUP9901739A3 (xx)
ID (1) ID16575A (xx)
IL (1) IL126476A0 (xx)
IS (1) IS4862A (xx)
NO (1) NO984761L (xx)
NZ (1) NZ331932A (xx)
PL (1) PL329308A1 (xx)
SK (1) SK134698A3 (xx)
TR (1) TR199802060T2 (xx)
WO (1) WO1997038977A1 (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011658A1 (en) 1997-08-29 1999-03-11 Proteus Molecular Design Ltd. Meta-benzamidine derivatives as serin protease inhibitors
WO1999011622A1 (en) * 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Amino-substituted compounds, methods, and compositions for inhibiting parp activity
CA2338304A1 (en) 1998-07-24 2000-02-03 Bayer Aktiengesellschaft Substituted benzoylcyclohexandiones
IT1302677B1 (it) * 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
TW575567B (en) * 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
SE9901530D0 (sv) * 1999-04-28 1999-04-28 Astra Pharma Prod Novel compounds
DE19920791A1 (de) 1999-05-06 2000-11-09 Bayer Ag Substituierte Benzoylisoxazole
DE19921424A1 (de) 1999-05-08 2000-11-09 Bayer Ag Substituierte Benzoylketone
DE19946853A1 (de) 1999-09-30 2001-04-05 Bayer Ag Substituierte Arylketone
TW591031B (en) * 2000-02-29 2004-06-11 Takeda Chemical Industries Ltd Thienopyridine derivatives, their production and use
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
CN103936690B (zh) 2005-10-25 2016-06-08 盐野义制药株式会社 氨基二氢噻嗪衍生物
TW200804290A (en) * 2005-11-15 2008-01-16 Astrazeneca Ab Compounds and uses thereof
JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
US8168630B2 (en) 2007-04-24 2012-05-01 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives substituted with a cyclic group
MX2010013256A (es) 2008-06-13 2010-12-21 Shionogi & Co Derivado heterociclico que contiene azufre que tiene actividad inhibitoria de beta-secretasa.
CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
WO2011071135A1 (ja) 2009-12-11 2011-06-16 塩野義製薬株式会社 オキサジン誘導体
CN101863900B (zh) * 2010-06-29 2012-07-25 天津药物研究院 一氧化氮供体型噻吩并吡啶衍生物、其制备方法和用途
EP2634186A4 (en) 2010-10-29 2014-03-26 Shionogi & Co naphthyridine
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
TW201247635A (en) 2011-04-26 2012-12-01 Shionogi & Co Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663550A (en) * 1968-12-25 1972-05-16 Shionogi & Co 2-lower alkyl-2,3-dihydrothieno(3,2-c)quinoline oxides
US3903095A (en) * 1972-02-18 1975-09-02 Merck & Co Inc Certain substituted-thieno{8 3,2-c{9 -pyridines
GB1379111A (en) * 1972-04-13 1975-01-02 Aspro Nicholas Ltd Preparation of fused-ring pyridine and pyrazine derivatives
US4127720A (en) * 1977-09-21 1978-11-28 Bristol-Myers Company Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
JPH04348326A (ja) * 1990-07-09 1992-12-03 Sumitomo Electric Ind Ltd 有機非線形光学材料
EP0724570B1 (en) * 1993-10-21 1999-03-03 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
KR20000005388A (ko) 2000-01-25
EP0892784A1 (en) 1999-01-27
CZ327698A3 (cs) 1999-05-12
TR199802060T2 (xx) 1999-01-18
IL126476A0 (en) 1999-08-17
SK134698A3 (en) 1999-06-11
NZ331932A (en) 2000-02-28
AR006619A1 (es) 1999-09-08
IS4862A (is) 1998-10-07
ID16575A (id) 1997-10-16
BR9708607A (pt) 1999-08-03
US6063789A (en) 2000-05-16
AU2655097A (en) 1997-11-07
PL329308A1 (en) 1999-03-15
CN1221407A (zh) 1999-06-30
AU706110B2 (en) 1999-06-10
JP2000509028A (ja) 2000-07-18
EE9800339A (et) 1999-04-15
WO1997038977A1 (en) 1997-10-23
HUP9901739A3 (en) 2000-06-28
CA2251681A1 (en) 1997-10-23
HUP9901739A2 (hu) 1999-09-28
NO984761D0 (no) 1998-10-12

Similar Documents

Publication Publication Date Title
NO984761L (no) Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler
NO20064089L (no) Kondensert ring 4-oksopyrimidinderivat
NO20072116L (no) Farmasoytiske forbindelser
ATE353870T1 (de) Dibenzylaminverbindung und deren medizinische verwendung
NO20092770L (no) Nye aminopyrimidinderivater som PLK1-inhibitorer
NO20055316L (no) Nye heterocykliske forbindelser som er nyttige ved behandling av inflammatoriske og allergiske forstyrrelser, fremgangsmate for fremstilling derav og farmasoytiske sammensetninger som inneholder slike
PL373888A1 (en) 3-heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides
NO20053483L (no) 4-Anilinokinazolinderivater for behandling av unormal cellevekst
NO20052038L (no) Ny adeninforbindelse og anvendelse derav
NO20083114L (no) Polysykliske indazolderivater som er ERK-inhibitorer
NO20063599L (no) Ytterligere heterosykliske forbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister
KR950003275A (ko) 1-벤젠술포닐-1, 3-디히드로-2h-벤즈이미다졸-2-온 유도체
NO20062370L (no) Amidderivater
NO20064400L (no) Prolin-derivater, og anvendelse av samme som inhibitorer av dipeptidyl peptidase IV
MY142807A (en) Benzimidazole derivative and use thereof.
EP1813270A4 (en) PROTEIN INHIBITORS OF THE HSP90 FAMILY
NO20060147L (no) Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
NO20072806L (no) Aryloksy-substituerte benzimidazolderivater
EP1679069A4 (en) NEW PIPERIDINE DERIVATIVE
EA200601177A1 (ru) Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов
FI942635A (fi) Piperatsiinijohdannaiset 5HT1A-antagonisteina
DE3868301D1 (de) 2-(methyl(4-piperidinyl))-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indolderivate, ihre herstellung und therapeutische verwendung.
NO20072643L (no) Fenylpiperazinmethanonderivater
NO20065918L (no) Tetrahydroioskinolonderivater, fremstilling derav og anvendelse som terapeutisk middel
NO20073283L (no) Nye pyridotienopyrimidinderivater

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application