NO20065918L - Tetrahydroioskinolonderivater, fremstilling derav og anvendelse som terapeutisk middel - Google Patents

Tetrahydroioskinolonderivater, fremstilling derav og anvendelse som terapeutisk middel

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Publication number
NO20065918L
NO20065918L NO20065918A NO20065918A NO20065918L NO 20065918 L NO20065918 L NO 20065918L NO 20065918 A NO20065918 A NO 20065918A NO 20065918 A NO20065918 A NO 20065918A NO 20065918 L NO20065918 L NO 20065918L
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NO
Norway
Prior art keywords
group
alkylidene
alkyl
hydrogen atom
optionally substituted
Prior art date
Application number
NO20065918A
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English (en)
Other versions
NO338104B1 (no
Inventor
Juan Antonio Diaz Martin
Maria Dolores Jimenez Bargueno
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Sanofi Aventis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34944870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20065918(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20065918L publication Critical patent/NO20065918L/no
Publication of NO338104B1 publication Critical patent/NO338104B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Det er beskrevet en forbindelse av formel (I), hvori n kan bety en verdi mellom 1 og 6; -(C)n- betyr en C1-6 alkyliden gruppe, eventuelt substituert med mellom 1 og 4 substitu-enter; RI betyr et hydrogenatom eller en C1-6 alkyl gruppe; R2 betyr et hydrogenatom, en C1-6 alkyl eller C3.6 sykloalkyl gruppe, eventuelt substituert med mellom 1 og 4 substituenter; og B betyr NR3R4, idet R3 og R4 uavhengig av hverandre betyr en C1-6 alkyl gruppe eller et hydrogenatom, eller betyr sammen en Q.6 alkyliden gruppe, en C2-8 alkenyliden gruppe, en C 1.3 alkyliden-O-Ci-3 alkyliden gruppe eller en C 1.3 alkyliden-N(R5)-Ci-3 alkyliden gruppe, hvor R5 betyr et hydrogenatom, eller en C1-3 alkyl eller C1-6 alkylkarbonylgruppe, idet nevnte C1.3 alkyl og C1-6 alkylkarbonyl grupper er sub stituerbare, eller en aminosyklus som er forbundet via et karbonatom til gruppen -NR1-(C)n-, så som aziridin, azetidin, pyrrolidin, piperidin eller morfolin, idet gruppene R3, R4, aminosyklusen og nitrogenatomet eventuelt er substituerte. Oppfinnelsen kan anvendes innenfor terapi.
NO20065918A 2004-05-25 2006-12-19 Tetrahydroisoquinolin-sulfonamid-derivater, farmasøytiske preparater inneholdende slike og anvendelse derav som terapeutisk middel NO338104B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0405607A FR2870846B1 (fr) 2004-05-25 2004-05-25 Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
PCT/FR2005/001279 WO2005118547A1 (fr) 2004-05-25 2005-05-24 Derives de tetrahydroisoquinolilsulfonamides, leur preparation et leur utilisation en therapeutique

Publications (2)

Publication Number Publication Date
NO20065918L true NO20065918L (no) 2006-12-19
NO338104B1 NO338104B1 (no) 2016-08-01

Family

ID=34944870

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065918A NO338104B1 (no) 2004-05-25 2006-12-19 Tetrahydroisoquinolin-sulfonamid-derivater, farmasøytiske preparater inneholdende slike og anvendelse derav som terapeutisk middel

Country Status (41)

Country Link
US (3) US7833999B2 (no)
EP (1) EP1753725B1 (no)
JP (1) JP4861979B2 (no)
KR (1) KR101176675B1 (no)
CN (1) CN1956962B (no)
AR (1) AR050250A1 (no)
AU (1) AU2005250197B2 (no)
BR (1) BRPI0511581A (no)
CA (1) CA2565293C (no)
CR (1) CR8735A (no)
CY (1) CY1114240T1 (no)
DK (1) DK1753725T3 (no)
DO (1) DOP2005000103A (no)
EA (1) EA010234B1 (no)
EC (1) ECSP067020A (no)
ES (1) ES2407140T3 (no)
FR (1) FR2870846B1 (no)
GT (1) GT200500126A (no)
HK (1) HK1106229A1 (no)
HN (1) HN2005000239A (no)
HR (1) HRP20130431T1 (no)
IL (1) IL179021A (no)
JO (1) JO2877B1 (no)
MA (1) MA28720B1 (no)
MX (1) MXPA06013629A (no)
MY (1) MY148980A (no)
NI (1) NI200600279A (no)
NO (1) NO338104B1 (no)
NZ (1) NZ551509A (no)
PA (1) PA8634501A1 (no)
PE (1) PE20060273A1 (no)
PL (1) PL1753725T3 (no)
PT (1) PT1753725E (no)
SI (1) SI1753725T1 (no)
SV (1) SV2006002126A (no)
TN (1) TNSN06356A1 (no)
TW (1) TWI360540B (no)
UA (1) UA84771C2 (no)
UY (1) UY28917A1 (no)
WO (1) WO2005118547A1 (no)
ZA (1) ZA200609820B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2870846B1 (fr) * 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
EP1790646A1 (fr) * 2005-11-24 2007-05-30 Sanofi-Aventis Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
KR101571176B1 (ko) 2007-11-13 2015-11-23 다이쇼 세이야꾸 가부시끼가이샤 페닐피라졸 유도체
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
CA2766154C (en) * 2009-06-26 2015-04-07 Beverly C. Langevin Novel fumarate salts of a histamine h3 receptor antagonist
AR080374A1 (es) * 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
AU2012349290B2 (en) 2011-12-08 2017-03-23 Taisho Pharmaceutical Co., Ltd. Phenylpyrrole derivative
US20150045553A1 (en) 2011-12-27 2015-02-12 Taisho Pharmaceutical Co., Ltd Phenyltriazole derivative
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
SG11201601306QA (en) * 2013-09-09 2016-03-30 Sanofi Sa An h3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease
CN110642854A (zh) * 2019-11-20 2020-01-03 成都克莱蒙医药科技有限公司 一种稠环化合物的多晶型、其组合物、制备方法及其应用
WO2022113008A1 (en) 2020-11-27 2022-06-02 Richter Gedeon Nyrt. Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder

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Also Published As

Publication number Publication date
JP4861979B2 (ja) 2012-01-25
CN1956962A (zh) 2007-05-02
SI1753725T1 (sl) 2013-06-28
EP1753725B1 (fr) 2013-02-27
ES2407140T3 (es) 2013-06-11
CY1114240T1 (el) 2016-08-31
TNSN06356A1 (en) 2008-02-22
CR8735A (es) 2007-08-28
DK1753725T3 (da) 2013-05-27
TWI360540B (en) 2012-03-21
DOP2005000103A (es) 2006-02-15
MY148980A (en) 2013-06-28
MA28720B1 (fr) 2007-07-02
KR20070021223A (ko) 2007-02-22
AU2005250197B2 (en) 2010-09-23
MXPA06013629A (es) 2007-03-23
ZA200609820B (en) 2008-06-25
WO2005118547A1 (fr) 2005-12-15
US7833999B2 (en) 2010-11-16
CA2565293A1 (fr) 2005-12-15
US20110028475A1 (en) 2011-02-03
NI200600279A (es) 2008-01-22
FR2870846B1 (fr) 2006-08-04
HRP20130431T1 (en) 2013-06-30
UY28917A1 (es) 2005-12-30
JO2877B1 (en) 2015-03-15
PE20060273A1 (es) 2006-04-22
HN2005000239A (es) 2009-04-27
SV2006002126A (es) 2006-01-13
CA2565293C (fr) 2012-10-30
PT1753725E (pt) 2013-05-21
UA84771C2 (uk) 2008-11-25
JP2008500313A (ja) 2008-01-10
KR101176675B1 (ko) 2012-08-23
HK1106229A1 (en) 2008-03-07
EP1753725A1 (fr) 2007-02-21
US8524700B2 (en) 2013-09-03
AR050250A1 (es) 2006-10-11
AU2005250197A1 (en) 2005-12-15
IL179021A (en) 2012-04-30
NO338104B1 (no) 2016-08-01
EA010234B1 (ru) 2008-06-30
ECSP067020A (es) 2006-12-29
FR2870846A1 (fr) 2005-12-02
US20120323003A1 (en) 2012-12-20
IL179021A0 (en) 2007-03-08
US20070105834A1 (en) 2007-05-10
GT200500126A (es) 2006-02-17
US8273733B2 (en) 2012-09-25
TW200609220A (en) 2006-03-16
CN1956962B (zh) 2014-08-20
EA200602176A1 (ru) 2007-04-27
NZ551509A (en) 2009-12-24
PL1753725T3 (pl) 2013-07-31
PA8634501A1 (es) 2006-05-16
BRPI0511581A (pt) 2008-01-02

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