NO980814D0 - Nye 2,3-diokso-1,2,3,4-tetrahydro-quinoyksalinyl-derivater - Google Patents

Nye 2,3-diokso-1,2,3,4-tetrahydro-quinoyksalinyl-derivater

Info

Publication number
NO980814D0
NO980814D0 NO980814A NO980814A NO980814D0 NO 980814 D0 NO980814 D0 NO 980814D0 NO 980814 A NO980814 A NO 980814A NO 980814 A NO980814 A NO 980814A NO 980814 D0 NO980814 D0 NO 980814D0
Authority
NO
Norway
Prior art keywords
tetrahydroquinoxalinyl
dioxo
derivatives
new
tetrahydroquinoxalinyl derivatives
Prior art date
Application number
NO980814A
Other languages
English (en)
Other versions
NO310236B1 (no
NO980814L (no
Inventor
Pierre Acklin
Hans Allgeier
Yves Auberson
Michel Biollaz
Robert Moretti
Silvio Ofner
Siem Jacob Veenstra
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO980814D0 publication Critical patent/NO980814D0/no
Publication of NO980814L publication Critical patent/NO980814L/no
Publication of NO310236B1 publication Critical patent/NO310236B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19980814A 1995-08-31 1998-02-26 Nye 2,3-diokso-1,2,3,4-tetrahydro-quinoksalinylderivater og farmasöytisk sammensetning omfattende samme NO310236B1 (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH247995 1995-08-31
CH273495 1995-09-27
CH274795 1995-09-28
CH121396 1996-05-10
CH163096 1996-06-28
PCT/EP1996/003644 WO1997008155A1 (en) 1995-08-31 1996-08-19 Novel 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives

Publications (3)

Publication Number Publication Date
NO980814D0 true NO980814D0 (no) 1998-02-26
NO980814L NO980814L (no) 1998-04-21
NO310236B1 NO310236B1 (no) 2001-06-11

Family

ID=27508939

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980814A NO310236B1 (no) 1995-08-31 1998-02-26 Nye 2,3-diokso-1,2,3,4-tetrahydro-quinoksalinylderivater og farmasöytisk sammensetning omfattende samme

Country Status (26)

Country Link
US (1) US6080743A (no)
EP (1) EP0853617B1 (no)
JP (1) JP3159711B2 (no)
KR (1) KR100462337B1 (no)
CN (1) CN1137886C (no)
AR (1) AR005229A1 (no)
AT (1) ATE260902T1 (no)
AU (1) AU705871B2 (no)
BR (1) BRPI9603626B8 (no)
CA (1) CA2227851C (no)
CZ (1) CZ56298A3 (no)
DE (1) DE69631774T2 (no)
DK (1) DK0853617T3 (no)
ES (1) ES2217324T3 (no)
HK (1) HK1010196A1 (no)
HU (1) HUP9801676A3 (no)
IL (1) IL122987A (no)
MY (1) MY132385A (no)
NO (1) NO310236B1 (no)
NZ (1) NZ316497A (no)
PL (1) PL189637B1 (no)
PT (1) PT853617E (no)
SI (1) SI0853617T1 (no)
SK (1) SK25298A3 (no)
TR (1) TR199800349T2 (no)
WO (1) WO1997008155A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191134B1 (en) * 1996-06-05 2001-02-20 Warner-Lambert Company Amide derivatives of substituted quinoxaline 2, 3-diones as glutamate receptor antagonists
SK282548B6 (sk) * 1996-10-24 2002-10-08 Novartis Ag Substituované aminoalkánfosfónové kyseliny, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie
AU5367598A (en) * 1996-11-25 1998-06-22 Warner-Lambert Company Urea and thiourea derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
US6172065B1 (en) 1997-03-04 2001-01-09 Warner-Lambert Company Urea and thiourea derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US6340758B1 (en) 1997-05-16 2002-01-22 Warner-Lambert Company Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
US6096744A (en) * 1998-05-04 2000-08-01 Warner-Lambert Company Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
AU2001216218A1 (en) 2000-05-25 2001-12-11 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
CA2440284A1 (en) * 2001-03-08 2002-09-19 Emory University Ph-dependent nmda receptor antagonists
TW200403066A (en) * 2002-04-30 2004-03-01 Novartis Ag New uses of substituted aminoalkanephosphonic acids
GB0310868D0 (en) * 2003-05-12 2003-06-18 Novartis Ag Organic compounds
US7524837B2 (en) * 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
CA2540638A1 (en) * 2003-09-30 2005-04-14 Janssen Pharmaceutica N.V. Quinoxaline compounds
US20060020029A1 (en) * 2004-07-02 2006-01-26 Shimasaki Craig D Pharmaceutical compositions from ethnobotanicals
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
CA2693032A1 (en) * 2007-06-29 2009-01-08 Emory University Nmda receptor antagonists for neuroprotection
CN102906085A (zh) * 2010-05-20 2013-01-30 诺瓦提斯公司 2,4-二氧代-1,4-二氢-2h-喹唑啉-3-基-磺酰胺衍生物
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
JO3225B1 (ar) * 2012-11-27 2018-03-08 Lilly Co Eli 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8
CN103435561B (zh) * 2013-08-19 2016-08-10 上海交通大学 一种新型d-氨基酸氧化酶抑制剂及其制备和应用
JP7068322B2 (ja) 2017-01-27 2022-05-16 ジェンフィ 自己免疫疾患を治療するためのrorガンマモジュレーターとしてのn-{[2-(ピペリジン-1-イル)フェニル](フェニル)メチル}-2-(3-オキソ-3,4-ジヒドロ-2h-1,4-ベンゾオキサジン-7-イル)アセトアミド誘導体及び関連化合物
KR102609676B1 (ko) 2017-06-12 2023-12-05 글리테크 엘엘씨. Nmda 길항제 및 d2/5ht2a 또는 선택적 5ht2a 길항제를 이용한 우울증의 치료

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
EP0484437A4 (en) * 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) * 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
WO1997008155A1 (en) 1997-03-06
CN1193968A (zh) 1998-09-23
JPH11511444A (ja) 1999-10-05
DK0853617T3 (da) 2004-07-05
US6080743A (en) 2000-06-27
AU6874296A (en) 1997-03-19
TR199800349T2 (xx) 1998-09-21
KR100462337B1 (ko) 2005-02-28
PT853617E (pt) 2004-06-30
CA2227851A1 (en) 1997-03-06
CA2227851C (en) 2009-01-06
HK1010196A1 (en) 1999-06-17
JP3159711B2 (ja) 2001-04-23
KR19990044275A (ko) 1999-06-25
DE69631774T2 (de) 2005-01-13
EP0853617A1 (en) 1998-07-22
CN1137886C (zh) 2004-02-11
BRPI9603626B1 (pt) 2016-08-23
PL189637B1 (pl) 2005-09-30
ES2217324T3 (es) 2004-11-01
MY132385A (en) 2007-10-31
EP0853617B1 (en) 2004-03-03
IL122987A (en) 2001-08-08
NO310236B1 (no) 2001-06-11
NO980814L (no) 1998-04-21
DE69631774D1 (de) 2004-04-08
IL122987A0 (en) 1998-08-16
BRPI9603626B8 (pt) 2021-07-06
NZ316497A (en) 2000-01-28
HUP9801676A2 (hu) 1999-03-29
AR005229A1 (es) 1999-04-28
MX9801643A (es) 1998-08-30
CZ56298A3 (cs) 1998-06-17
SI0853617T1 (en) 2004-08-31
SK25298A3 (en) 1998-09-09
AU705871B2 (en) 1999-06-03
HUP9801676A3 (en) 1999-04-28
PL324992A1 (en) 1998-07-06
ATE260902T1 (de) 2004-03-15

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