NO975504L - Method for detecting compounds that modulate the effects of the fat protein - Google Patents

Method for detecting compounds that modulate the effects of the fat protein

Info

Publication number
NO975504L
NO975504L NO975504A NO975504A NO975504L NO 975504 L NO975504 L NO 975504L NO 975504 A NO975504 A NO 975504A NO 975504 A NO975504 A NO 975504A NO 975504 L NO975504 L NO 975504L
Authority
NO
Norway
Prior art keywords
fat protein
compound
effect
fat
modulate
Prior art date
Application number
NO975504A
Other languages
Norwegian (no)
Other versions
NO975504D0 (en
Inventor
Lee James Beeley
Richard Anthony Godwin Smith
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9510857.7A external-priority patent/GB9510857D0/en
Priority claimed from GBGB9511602.6A external-priority patent/GB9511602D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO975504D0 publication Critical patent/NO975504D0/en
Publication of NO975504L publication Critical patent/NO975504L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En fremgangsmåte for deteksjon av en forbindelse som mimikerer, potensierer eller inhiberer den fysiologiske virkningen av fettproteinet, hvor metoden omfatter: (a) for en forbindelse som mimikerer den fysiologiske virkningen av fettproteinet, vurdere virkningen av forbindelsen på en fettproteinaktivert signaltransduser og aktivator av transkripsjon (STAT) DNA-responselement koblet til et rapportørgen; eller (b) for en forbindelse som potensierer eller inhiberer den fysiologiske virkning av fettproteinet, vurdere virkningen av forbindelsen etter responsen frembragt av fett- proteinet på et fettproteinaktivert STAT DNA-responselement koblet til et rapportør- gen; responselementet og rapportøren blir uttrykt i en fettproteinresponsiv cellelinje; et "kit" av deler adaptert til anvendelse i en slik fremgangsmåte og en forbindelse identifisert ved en slik fremgangsmåte.A method for detecting a compound that mimics, potentiates or inhibits the physiological effect of the fat protein, the method comprising: (a) for a compound that mimics the physiological effect of the fat protein, assessing the effect of the compound on a fat protein-activated signal transducer and activator of transcription ( STAT) DNA response element coupled to a reporter gene; or (b) for a compound that potentiates or inhibits the physiological effect of the fat protein, consider the effect of the compound after the response produced by the fat protein on a fat protein-activated STAT DNA response element coupled to a reporter gene; the response element and reporter are expressed in a fat protein responsive cell line; a "kit" of parts adapted for use in such a method and a compound identified by such a method.

NO975504A 1995-05-30 1997-11-28 Method for detecting compounds that modulate the effects of the fat protein NO975504L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9510857.7A GB9510857D0 (en) 1995-05-30 1995-05-30 Novel assay
GBGB9511602.6A GB9511602D0 (en) 1995-06-08 1995-06-08 Novel assay
PCT/EP1996/002291 WO1996038586A1 (en) 1995-05-30 1996-05-28 Method for the detection of compounds that modulate the effects of the obese protein

Publications (2)

Publication Number Publication Date
NO975504D0 NO975504D0 (en) 1997-11-28
NO975504L true NO975504L (en) 1997-11-28

Family

ID=26307107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975504A NO975504L (en) 1995-05-30 1997-11-28 Method for detecting compounds that modulate the effects of the fat protein

Country Status (15)

Country Link
EP (1) EP0832284A1 (en)
JP (1) JPH11505725A (en)
KR (1) KR19990022134A (en)
CN (1) CN1192248A (en)
AU (1) AU715215B2 (en)
BR (1) BR9608686A (en)
CA (1) CA2222409A1 (en)
CZ (1) CZ379097A3 (en)
HU (1) HUP9801744A3 (en)
MX (1) MX9709360A (en)
NO (1) NO975504L (en)
NZ (1) NZ309777A (en)
PL (1) PL323638A1 (en)
TR (1) TR199701469T1 (en)
WO (1) WO1996038586A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6001968A (en) * 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6007998A (en) * 1996-04-22 1999-12-28 Merck & Co., Inc. Leptin assay
WO1997040380A1 (en) * 1996-04-22 1997-10-30 Merck & Co., Inc. Leptin assay
US6001816A (en) * 1996-06-20 1999-12-14 Merck & Co., Inc. Gene therapy for leptin deficiency
WO1998020158A1 (en) * 1996-11-01 1998-05-14 Smithkline Beecham Plc Method for the detection of compounds that modulate the effects of the obese (ob) protein
IT1293533B1 (en) * 1997-07-14 1999-03-01 Angeletti P Ist Richerche Bio METHOD FOR THE SELECTION OF MOLECULES ABLE TO MIMIC, INHIBIT OR ENHANCE THE EFFECTS OF THE INTERACTION BETWEEN LEPTIN AND CELLS THAT
WO1999023493A1 (en) * 1997-10-31 1999-05-14 The Rockefeller University Methods of identifying agents that modulate leptin activity
WO1999040946A2 (en) * 1998-02-11 1999-08-19 Beth Israel Deaconess Medical Center Methods and compositions for modulating leptin activity
GB9814199D0 (en) * 1998-06-30 1998-08-26 Univ Buckingham Novel method
GB9828087D0 (en) * 1998-12-18 1999-02-17 Smithkline Beecham Plc Novel method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008001A1 (en) * 1993-09-15 1995-03-23 New York University Dna sequence which binds transcriptional regulatory proteins activated in response to various cytokines and uses thereof
CA2165057A1 (en) * 1994-04-14 1995-10-26 H. Martin Seidel Dna spacer regulatory elements responsive to cytokines and methods for their use

Also Published As

Publication number Publication date
BR9608686A (en) 1999-07-06
NZ309777A (en) 2000-01-28
HUP9801744A3 (en) 2000-06-28
CA2222409A1 (en) 1996-12-05
NO975504D0 (en) 1997-11-28
JPH11505725A (en) 1999-05-25
CN1192248A (en) 1998-09-02
EP0832284A1 (en) 1998-04-01
CZ379097A3 (en) 1998-05-13
TR199701469T1 (en) 1998-03-21
AU715215B2 (en) 2000-01-20
MX9709360A (en) 1998-02-28
KR19990022134A (en) 1999-03-25
AU6002396A (en) 1996-12-18
PL323638A1 (en) 1998-04-14
WO1996038586A1 (en) 1996-12-05
HUP9801744A2 (en) 1998-10-28

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