NO972461L - Fremstilling av cefem- og isooxacefemderivater - Google Patents
Fremstilling av cefem- og isooxacefemderivaterInfo
- Publication number
- NO972461L NO972461L NO972461A NO972461A NO972461L NO 972461 L NO972461 L NO 972461L NO 972461 A NO972461 A NO 972461A NO 972461 A NO972461 A NO 972461A NO 972461 L NO972461 L NO 972461L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- aryl
- formula
- heterocyclyl
- cycloalkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- -1 carboxy, amino Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Oppfinnelsen vedrører en ny fremgangsmåte ved fremstilling av forbindelser med formel OR. hvor COOH wer trityl, acetyl, tetrahydropyranyl eller syklopentyl,er hydrogen, hydroksy, lavere alkyl, sykloalkyl, lavere alkoksy, lavere alkenyl, lavere alkynyl, aryl, aryloksy, aryl-lavere alkyl, aryl-lavere alkoksy eller heterosyklyl, eller heterosyklyl-lavere alkyl, den lavere alkyl, sykloalkyl, lavere alkoksy, lavere alkenyl, sykloalkenyl, lavere alkynyl, aryl-lavere alkyl, aryl, aryloksy, aryl-lavere alkoksy, heterosyklyl bindinger usubstituert eller substituert med i det minste en gruppe valgt fra kar-boksy, amino, nitro, cyano, lavere alkyl, lavere alkoksy, hydroksy, halogen, -CONR22, -(2)COO23,CO-, ROCO- eller2COO-, hfor Rer hydrogen, lavere alkyl, eller sykloalkyl;er lavere alkyl, lavere alkenyl eller en karboksylsyre beskyttende gruppe: Y er -S- og Z er -CH- eller Y er -CH- og Z er -0-, ved å acylere en forbindelse med formelmed et aktivert karboksylsyrederivat med formel1x 1 x hvor RJ er lavere alkyl, R , R',X,Y og Z har betydningene angitt ovenfor: og den vedrorer videre forbindelser med formel III.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96109239 | 1996-06-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO972461D0 NO972461D0 (no) | 1997-05-29 |
| NO972461L true NO972461L (no) | 1997-12-11 |
Family
ID=8222876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO972461A NO972461L (no) | 1996-06-10 | 1997-05-29 | Fremstilling av cefem- og isooxacefemderivater |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5883247A (no) |
| EP (1) | EP0812846B1 (no) |
| JP (1) | JP2950795B2 (no) |
| KR (1) | KR100258652B1 (no) |
| CN (1) | CN1167766A (no) |
| AT (1) | ATE204282T1 (no) |
| AU (1) | AU697970B2 (no) |
| BR (1) | BR9703517A (no) |
| CA (1) | CA2206199A1 (no) |
| CZ (1) | CZ176997A3 (no) |
| DE (1) | DE69706099T2 (no) |
| DK (1) | DK0812846T3 (no) |
| ES (1) | ES2162158T3 (no) |
| HU (1) | HUP9701013A3 (no) |
| IL (1) | IL120991A (no) |
| NO (1) | NO972461L (no) |
| NZ (1) | NZ314991A (no) |
| PL (1) | PL320452A1 (no) |
| TR (1) | TR199700481A2 (no) |
| TW (1) | TW434244B (no) |
| ZA (1) | ZA974885B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT403049B (de) | 1995-08-14 | 1997-10-27 | Biochemie Gmbh | Abreicherung von 7-adca in 3-vinyl-aca |
| EP0841339B1 (en) | 1996-11-06 | 2007-02-21 | Basilea Pharmaceutica AG | Vinylpyrrolidinon cephalosporin derivatives |
| AU1654900A (en) * | 1998-12-03 | 2000-06-19 | F. Hoffmann-La Roche Ag | Bi-pyrrolidinylvinl (carba) cephalosporins |
| KR100320671B1 (ko) * | 1999-11-04 | 2002-01-17 | 이균철 | 방폭 방탄 안전 전투화 |
| US6504025B2 (en) * | 2000-05-24 | 2003-01-07 | Basilea Pharmaceutica Ag | Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives |
| KR101058135B1 (ko) | 2008-04-04 | 2011-08-24 | 대웅바이오 주식회사 | 세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법 |
| WO2011029596A1 (en) | 2009-09-11 | 2011-03-17 | Lonza Ltd | Process for preparing 2-aminothiazol-4-yl-acetic acid derivates |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3971778A (en) * | 1972-05-12 | 1976-07-27 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position |
| DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
| CH648317A5 (de) * | 1977-06-10 | 1985-03-15 | Yamanouchi Pharma Co Ltd | 7alpha-methoxy-7betha-(1,3-dithietan-2- carboxamido)cephalosporansaeurederivate und verfahren zu ihrer herstellung. |
| FR2439785A1 (fr) * | 1978-10-23 | 1980-05-23 | Roussel Uclaf | Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique |
| US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| US4576749A (en) * | 1983-10-03 | 1986-03-18 | E. R. Squibb & Sons, Inc. | 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones |
| TW212181B (no) * | 1992-02-14 | 1993-09-01 | Hoechst Ag | |
| KR950013578B1 (ko) * | 1993-04-10 | 1995-11-09 | 주식회사럭키 | 신규 티아(디아)졸 초산의 반응성 티오포스페이트 유도체 및 그의 제조방법 |
| US5523400A (en) * | 1993-04-16 | 1996-06-04 | Hoffmann-La Roche Inc. | Cephalosporin antibiotics |
| EP0620225B1 (en) * | 1993-04-16 | 2002-11-13 | Basilea Pharmaceutica AG | Cephalosporin derivatives |
| WO1996012712A1 (en) * | 1994-10-24 | 1996-05-02 | Miwon Co., Ltd. | Reactive phosphate derivatives of thiazolylacetic acid and process for preparing cephalosporin antibiotics using the same |
| WO1996026943A1 (en) * | 1995-02-27 | 1996-09-06 | F.Hoffmann-La Roche Ag | Derivatives of 3-pyrrolidylidene-2-one-cephalosporines |
| JP3948628B2 (ja) * | 1995-12-27 | 2007-07-25 | ハンミ ファーマシューティカル シーオー．，エルティーディー． | セフディニルの製造方法 |
-
1997
- 1997-05-14 US US08/856,070 patent/US5883247A/en not_active Expired - Fee Related
- 1997-05-23 TW TW086106970A patent/TW434244B/zh active
- 1997-05-27 CA CA002206199A patent/CA2206199A1/en not_active Abandoned
- 1997-05-29 NO NO972461A patent/NO972461L/no not_active Application Discontinuation
- 1997-06-03 ZA ZA974885A patent/ZA974885B/xx unknown
- 1997-06-03 NZ NZ314991A patent/NZ314991A/xx unknown
- 1997-06-04 IL IL12099197A patent/IL120991A/xx not_active IP Right Cessation
- 1997-06-05 EP EP97109069A patent/EP0812846B1/en not_active Expired - Lifetime
- 1997-06-05 AT AT97109069T patent/ATE204282T1/de not_active IP Right Cessation
- 1997-06-05 DE DE69706099T patent/DE69706099T2/de not_active Expired - Fee Related
- 1997-06-05 DK DK97109069T patent/DK0812846T3/da active
- 1997-06-05 ES ES97109069T patent/ES2162158T3/es not_active Expired - Lifetime
- 1997-06-06 AU AU24746/97A patent/AU697970B2/en not_active Ceased
- 1997-06-06 HU HU9701013A patent/HUP9701013A3/hu unknown
- 1997-06-09 KR KR1019970023548A patent/KR100258652B1/ko not_active IP Right Cessation
- 1997-06-09 CZ CZ971769A patent/CZ176997A3/cs unknown
- 1997-06-09 JP JP9151131A patent/JP2950795B2/ja not_active Expired - Fee Related
- 1997-06-09 CN CN97105447A patent/CN1167766A/zh active Pending
- 1997-06-09 TR TR97/00481A patent/TR199700481A2/xx unknown
- 1997-06-09 PL PL97320452A patent/PL320452A1/xx unknown
- 1997-06-10 BR BR9703517A patent/BR9703517A/pt active Search and Examination
-
1998
- 1998-05-20 US US09/081,759 patent/US5919939A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW434244B (en) | 2001-05-16 |
| CZ176997A3 (en) | 1997-12-17 |
| CA2206199A1 (en) | 1997-12-10 |
| KR100258652B1 (ko) | 2000-07-01 |
| MX9704258A (es) | 1998-07-31 |
| NO972461D0 (no) | 1997-05-29 |
| HUP9701013A1 (hu) | 1998-08-28 |
| ZA974885B (en) | 1998-08-26 |
| ATE204282T1 (de) | 2001-09-15 |
| DE69706099D1 (de) | 2001-09-20 |
| EP0812846B1 (en) | 2001-08-16 |
| IL120991A0 (en) | 1997-11-20 |
| ES2162158T3 (es) | 2001-12-16 |
| AU697970B2 (en) | 1998-10-22 |
| JPH1059978A (ja) | 1998-03-03 |
| KR980002053A (ko) | 1998-03-30 |
| AU2474697A (en) | 1997-12-18 |
| BR9703517A (pt) | 1998-12-29 |
| CN1167766A (zh) | 1997-12-17 |
| IL120991A (en) | 2000-07-26 |
| DK0812846T3 (da) | 2001-11-12 |
| HUP9701013A3 (en) | 2001-04-28 |
| EP0812846A1 (en) | 1997-12-17 |
| US5919939A (en) | 1999-07-06 |
| PL320452A1 (en) | 1997-12-22 |
| US5883247A (en) | 1999-03-16 |
| NZ314991A (en) | 2000-01-28 |
| HU9701013D0 (en) | 1997-07-28 |
| DE69706099T2 (de) | 2002-05-02 |
| TR199700481A2 (xx) | 1997-12-21 |
| JP2950795B2 (ja) | 1999-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |