NO972228L - Nytt tumorsuppresor-gen, HIC-1 - Google Patents

Nytt tumorsuppresor-gen, HIC-1

Info

Publication number
NO972228L
NO972228L NO972228A NO972228A NO972228L NO 972228 L NO972228 L NO 972228L NO 972228 A NO972228 A NO 972228A NO 972228 A NO972228 A NO 972228A NO 972228 L NO972228 L NO 972228L
Authority
NO
Norway
Prior art keywords
hic
tumor suppressor
suppressor gene
new tumor
prognostically
Prior art date
Application number
NO972228A
Other languages
English (en)
Other versions
NO972228D0 (no
Inventor
Stephen B Baylin
Michele Makos Wales
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Publication of NO972228D0 publication Critical patent/NO972228D0/no
Publication of NO972228L publication Critical patent/NO972228L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)

Abstract

Det beskrives polynukleotid- og polypeptidsekvenser som koder for en ny tumorsuppressor, HIC-1. Det beskrives også en fremgangsmåte for påvisning av en celleproliferaliv forstyrrelse assosiert med HIC-1. HIC-1 er en markør som kan benyttes diagnostisk, prognostisk og terapeutisk under slike forstyrrelser.
NO972228A 1994-11-15 1997-05-14 Nytt tumorsuppresor-gen, HIC-1 NO972228L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/340,203 US5756668A (en) 1994-11-15 1994-11-15 Hypermethylated in cancer polypeptide, HIC-1
PCT/US1995/014996 WO1996014877A1 (en) 1994-11-15 1995-11-15 Novel tumor suppressor gene, hic-1

Publications (2)

Publication Number Publication Date
NO972228D0 NO972228D0 (no) 1997-05-14
NO972228L true NO972228L (no) 1997-07-14

Family

ID=23332327

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972228A NO972228L (no) 1994-11-15 1997-05-14 Nytt tumorsuppresor-gen, HIC-1

Country Status (12)

Country Link
US (4) US5756668A (no)
EP (1) EP0792168A4 (no)
JP (1) JPH10510145A (no)
KR (1) KR970706849A (no)
CN (1) CN1171743A (no)
AU (1) AU4407196A (no)
BR (1) BR9509674A (no)
CA (1) CA2205414A1 (no)
FI (1) FI972066A (no)
NO (1) NO972228L (no)
NZ (1) NZ298554A (no)
WO (1) WO1996014877A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617434B1 (en) 1996-05-31 2003-09-09 North Shore Long Island Jewish Research Institute Identificiaton of differentially methylated and mutated nucleic acids
US5871917A (en) 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US6287854B1 (en) 1996-10-22 2001-09-11 Imperial Cancer Research Technology Limited Diagnosis of susceptibility to cancer and treatment thereof
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
DE69737788T2 (de) * 1996-10-31 2008-03-13 Abbott Laboratories, Abbott Park Reagenzien und methoden zum nachweis von erkrankungen der brust
GB9710995D0 (en) * 1997-05-28 1997-07-23 Marie Curie Research Inst Tumour suppressor locus and gene at 9q32-33
US6251594B1 (en) 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
WO1999002714A1 (en) * 1997-07-07 1999-01-21 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
EP1032689A1 (en) * 1997-11-17 2000-09-06 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
SE513149C2 (sv) * 1997-12-05 2000-07-17 Katarina Edwards Läkemedelsdistributionssystem med tvåstegsmålsökning, till specifika celler eller vävnad och till dess cellkärna
US6994991B1 (en) 1998-11-18 2006-02-07 North Shore - Long Island Jewish Research Institute Identification of differentially methylated multiple drug resistance loci
US6783933B1 (en) * 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
US6911306B1 (en) * 1999-10-18 2005-06-28 Emory University TMS1 compositions and methods of use
US6468789B1 (en) 2000-02-02 2002-10-22 University Of Pittsburgh Oxygen sensing and hypoxic selection for tumors
EP1294947A2 (en) * 2000-06-30 2003-03-26 Epigenomics AG Method and nucleic acids for pharmacogenomic methylation analysis
WO2002068694A1 (en) * 2001-02-23 2002-09-06 The Johns Hopkins University School Of Medicine Differentially methylated sequences in pancreatic cancer
EP1373499B1 (en) * 2001-02-23 2017-09-20 Dana-Farber Cancer Institute, Inc. Hin-1, a tumor suppressor gene
AU2002341264B2 (en) * 2001-10-03 2007-07-12 Bioniche Life Sciences Inc. Therapeutically useful triethyleneglycol cholesteryl oligonucleotides
JP2007119359A (ja) * 2005-10-25 2007-05-17 Fujifilm Corp 癌抑制剤
WO2009079208A2 (en) * 2007-12-17 2009-06-25 Siemens Healthcare Diagnostics Inc. Methylation markers for cancer
US20140274757A1 (en) 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2001815C (en) * 1988-10-31 2002-09-03 Wen-Hwa Lee Products and methods for controlling the suppression of the neoplastic phenotype
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors

Also Published As

Publication number Publication date
AU4407196A (en) 1996-06-06
CA2205414A1 (en) 1996-05-23
US5756668A (en) 1998-05-26
KR970706849A (ko) 1997-12-01
US5846712A (en) 1998-12-08
BR9509674A (pt) 1997-09-16
FI972066A (fi) 1997-07-14
US6103877A (en) 2000-08-15
CN1171743A (zh) 1998-01-28
NO972228D0 (no) 1997-05-14
FI972066A0 (fi) 1997-05-14
JPH10510145A (ja) 1998-10-06
MX9703582A (es) 1997-10-31
EP0792168A4 (en) 1999-10-20
NZ298554A (en) 2000-01-28
US5922590A (en) 1999-07-13
EP0792168A1 (en) 1997-09-03
WO1996014877A1 (en) 1996-05-23

Similar Documents

Publication Publication Date Title
NO972228L (no) Nytt tumorsuppresor-gen, HIC-1
DK0771362T3 (da) Genetisk diagnose og farmaceutiske præparater til behandling af prostatacancer
ATE364089T1 (de) Reagenzien und methoden zum nachweis von erkrankungen der brust
NO975508L (no) DNA-sekvens og kodet bryst- spesifikt brystkreftprotein
DK32589D0 (da) Fremgangsmaade og apparat til foring af roer.
NZ332634A (en) Isolated autophosphorylating polypeptide having phosphoinositide-3-kinase activity
WO1999036550A3 (en) Human protease molecules
DE3871037D1 (de) Methode und apparat zum auskleiden von rohrleitungen.
TR199802676A2 (xx) T�m�rlerin, t�m�rle ilgili hastal�klar�n ve ka�eksinin tedavisi ve �nlenmesi i�in y�ntem.
NO903718D0 (no) Fremgangsmaate og apparat for bestemmelse av underjordiskestrukturer.
WO2000012711A3 (en) Human membrane channel proteins
DK0760010T3 (da) Fremgangsmåder til screening for Crohn's sygdom under anvendelse af TNF-mikrosatellit-alleler
NO882229D0 (no) Fremgangsmaate til hydrokrakking av hydrokarboner og apparat til utfoerelse av fremgangsmaaten.
NO855206L (no) Fremgangsmaate og apparat for regulering av vaeskenivaa.
IL92956A0 (en) Gene sequences which encode acylpeptide hydrolase and methods for detecting cancer utilizing the same
MX9705025A (es) Proteinas de matriz nuclear de vejiga y su uso para detectar y tratar trastornos proliferativos celulares.
DK0471687T3 (da) Fremgangsmåder og nucleinsyresekvenser til ekspression af cellulosesynthase-operonen
DK388889D0 (da) Fremgangsmaade og apparat til erosionsbestemmelse, isaer af havbunden
WO1999031128A3 (en) Human tumor necrosis factor-r2-like proteins
WO2000009526A3 (en) Method for dpc4 (smad4) nuclear localization
DE68920564D1 (de) Apparat zum optischen Profilieren eines Gegenstands.
EP0846263A4 (en) METHOD AND KIT FOR EVALUATING THE METASTATIC TREND OF TUMORS
DE3871006D1 (de) Apparat zum nachweisen der an- oder abwesenheit von wasserleck an wasserrohrleitungen.
AU7300998A (en) Receptor tyrosine kinase genes
AU3941002A (en) Cyp1b1 nucleic acids and methods of use

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application