NO971318L - Jodiserte röntgenkontrastmidler - Google Patents

Jodiserte röntgenkontrastmidler

Info

Publication number
NO971318L
NO971318L NO971318A NO971318A NO971318L NO 971318 L NO971318 L NO 971318L NO 971318 A NO971318 A NO 971318A NO 971318 A NO971318 A NO 971318A NO 971318 L NO971318 L NO 971318L
Authority
NO
Norway
Prior art keywords
group
groups
moiety
contrast agents
ray contrast
Prior art date
Application number
NO971318A
Other languages
English (en)
Other versions
NO971318D0 (no
Inventor
Anna Rydbeck
Torsten Almen
Mikkel Thaning
Sven Andersson
Lars-Goeran Wistrand
Klaes Golman
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO971318D0 publication Critical patent/NO971318D0/no
Publication of NO971318L publication Critical patent/NO971318L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Liquid Crystal (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Oppfinnelsen presenterer jodiserte bisfenylforbindelser, anvendelige som røntgenkontrastmidler, av formel (I) (hvor hver C^Rj-gruppene kan være like eller forskjellige; hvor hver R betegner et hydrogen- eller jodatom eller en gruppe M, to eller tre R- grupper som ikke er naboer på hver C^Rs-enhet betegner jodatomer og en, to eller tre R- grupper på hver C^Rs-enhet betegner M-grupper; hvor X betegner en gruppe med en 1, 2 eller 3 atomer lang kjede som binder de to C^Rj-gruppene sammen - når X er eller inneholder en karbonyloksygruppe i den sammenbindende kjeden er fortrinnsvis begge C^Rj-gruppene en trijodfenylgiuppe eller en gruppe hvor alle R er noe annet enn hydrogen; og hvor hver M er uavhengig av hverandre en ikkeionisk hydrofil gruppe og helst en ikkeionisk hydrofil gruppe som omfatter en monohydroksy- eller polyhydroksy-alkylgruppe) og isomerer, spesielt stereoisomerer og rotamerer av dette.
NO971318A 1994-09-23 1997-03-20 Jodiserte röntgenkontrastmidler NO971318L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9419206A GB9419206D0 (en) 1994-09-23 1994-09-23 Contrast media
PCT/GB1995/002264 WO1996009285A1 (en) 1994-09-23 1995-09-22 Iodinated x-ray-contrast media

Publications (2)

Publication Number Publication Date
NO971318D0 NO971318D0 (no) 1997-03-20
NO971318L true NO971318L (no) 1997-08-11

Family

ID=10761799

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971318A NO971318L (no) 1994-09-23 1997-03-20 Jodiserte röntgenkontrastmidler

Country Status (21)

Country Link
US (2) US5958375A (no)
EP (1) EP0782565B1 (no)
JP (1) JP3606583B2 (no)
AT (1) ATE178592T1 (no)
AU (1) AU710934B2 (no)
CA (1) CA2200752A1 (no)
CZ (1) CZ89497A3 (no)
DE (2) DE69508949D1 (no)
DK (1) DK0782565T3 (no)
EE (1) EE9700054A (no)
ES (1) ES2130650T3 (no)
FI (1) FI971200A (no)
GB (1) GB9419206D0 (no)
GR (1) GR3030425T3 (no)
HU (1) HUT77170A (no)
MX (1) MX9702088A (no)
NO (1) NO971318L (no)
NZ (1) NZ292974A (no)
PL (1) PL319367A1 (no)
SK (1) SK35597A3 (no)
WO (1) WO1996009285A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
WO2000066544A1 (en) * 1999-04-30 2000-11-09 Nycomed Imaging As Contrast media
DK1372674T3 (da) 2001-03-08 2011-09-12 Univ Pennsylvania Facialt amphiphile polymerer som anti-infektive midler
EP1608313A4 (en) 2003-03-17 2009-05-06 Univ Pennsylvania AMPHIPHILIC SURFACE POLYMERS AND OLIGOMERS AND USES THEREOF
US8551449B2 (en) * 2007-10-30 2013-10-08 Ge Healthcare As Contrast agents
JP2011509943A (ja) 2008-01-14 2011-03-31 マリンクロッド・インコーポレイテッド イオシメノールを調製するためのプロセス
JP5164755B2 (ja) * 2008-09-09 2013-03-21 キヤノン株式会社 ビス−アセチルアミノフェニル化合物の結晶の製造方法
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776241A (en) * 1952-08-06 1957-01-01 Schering Ag Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid
US2708678A (en) * 1954-01-15 1955-05-17 Schering Corp Iodinated acyl derivatives of 2, 4, 6-trhodometa-aminobenzoic acid
GB1033776A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Iodinated acid amides and esters and salts thereof
US3794729A (en) * 1971-07-16 1974-02-26 Schering Corp Inhibiting blood platelet aggregation
CH576255A5 (no) * 1972-11-17 1976-06-15 Bracco Ind Chimica Spa
DE2737802A1 (de) * 1977-08-22 1979-03-08 Henning Berlin Gmbh Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung
DE3037858A1 (de) * 1980-10-07 1982-05-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von reaktiven, kupplungsfaehigen derivaten der schilddruesenhormone t (pfeil abwaerts)3(pfeil abwaerts) und t (pfeil abwaerts)4(pfeil abwaerts) und deren verwendung
ATE79368T1 (de) * 1987-05-22 1992-08-15 Bracco Spa Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
NZ250063A (en) * 1992-12-14 1996-03-26 Eastman Kodak Co Iodinated aromatic acid ester derivatives; x-ray contrast compositions
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x

Also Published As

Publication number Publication date
EP0782565A1 (en) 1997-07-09
NO971318D0 (no) 1997-03-20
DE69508949D1 (de) 1999-05-12
ATE178592T1 (de) 1999-04-15
US5958376A (en) 1999-09-28
FI971200A0 (fi) 1997-03-21
DE69508949T2 (de) 1999-09-09
DK0782565T3 (da) 1999-10-18
DE69508949T4 (de) 1999-12-09
SK35597A3 (en) 1997-11-05
ES2130650T3 (es) 1999-07-01
FI971200A (fi) 1997-05-19
GB9419206D0 (en) 1994-11-09
AU710934B2 (en) 1999-09-30
NZ292974A (en) 1999-03-29
US5958375A (en) 1999-09-28
EE9700054A (et) 1997-08-15
PL319367A1 (en) 1997-08-04
CZ89497A3 (en) 1997-09-17
MX9702088A (es) 1997-06-28
JP3606583B2 (ja) 2005-01-05
WO1996009285A1 (en) 1996-03-28
GR3030425T3 (en) 1999-09-30
CA2200752A1 (en) 1996-03-28
HUT77170A (hu) 1998-03-02
AU3529395A (en) 1996-04-09
EP0782565B1 (en) 1999-04-07
JPH10505856A (ja) 1998-06-09

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