ATE178592T1 - Iodierte röntgenkontrastmittel - Google Patents

Iodierte röntgenkontrastmittel

Info

Publication number
ATE178592T1
ATE178592T1 AT95932108T AT95932108T ATE178592T1 AT E178592 T1 ATE178592 T1 AT E178592T1 AT 95932108 T AT95932108 T AT 95932108T AT 95932108 T AT95932108 T AT 95932108T AT E178592 T1 ATE178592 T1 AT E178592T1
Authority
AT
Austria
Prior art keywords
group
groups
moiety
contrast agents
iodinated
Prior art date
Application number
AT95932108T
Other languages
English (en)
Inventor
Anna Rydbeck
Torsten Almen
Mikkel Thaning
Sven Andersson
Lars-Goeran Wistrand
Klaes Golman
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Application granted granted Critical
Publication of ATE178592T1 publication Critical patent/ATE178592T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Liquid Crystal (AREA)
AT95932108T 1994-09-23 1995-09-22 Iodierte röntgenkontrastmittel ATE178592T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9419206A GB9419206D0 (en) 1994-09-23 1994-09-23 Contrast media

Publications (1)

Publication Number Publication Date
ATE178592T1 true ATE178592T1 (de) 1999-04-15

Family

ID=10761799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95932108T ATE178592T1 (de) 1994-09-23 1995-09-22 Iodierte röntgenkontrastmittel

Country Status (21)

Country Link
US (2) US5958375A (de)
EP (1) EP0782565B1 (de)
JP (1) JP3606583B2 (de)
AT (1) ATE178592T1 (de)
AU (1) AU710934B2 (de)
CA (1) CA2200752A1 (de)
CZ (1) CZ89497A3 (de)
DE (2) DE69508949D1 (de)
DK (1) DK0782565T3 (de)
EE (1) EE9700054A (de)
ES (1) ES2130650T3 (de)
FI (1) FI971200A (de)
GB (1) GB9419206D0 (de)
GR (1) GR3030425T3 (de)
HU (1) HUT77170A (de)
MX (1) MX9702088A (de)
NO (1) NO971318L (de)
NZ (1) NZ292974A (de)
PL (1) PL319367A1 (de)
SK (1) SK35597A3 (de)
WO (1) WO1996009285A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
DE60020960T2 (de) * 1999-04-30 2006-05-24 Amersham Health As Kontrastmittel
JP4170214B2 (ja) 2001-03-08 2008-10-22 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 抗感染用剤としての表面両親媒性ポリマー
CN102432511B (zh) 2003-03-17 2016-06-08 宾夕法尼亚州大学理事会 表面两亲聚合物和低聚物及其应用
WO2009056555A1 (en) * 2007-10-30 2009-05-07 Ge Healthcare As Contrast agents
EP2240432B1 (de) 2008-01-14 2012-07-04 Mallinckrodt LLC Verfahren zur herstellung von iosimenol
JP5164755B2 (ja) * 2008-09-09 2013-03-21 キヤノン株式会社 ビス−アセチルアミノフェニル化合物の結晶の製造方法
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776241A (en) * 1952-08-06 1957-01-01 Schering Ag Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid
US2708678A (en) * 1954-01-15 1955-05-17 Schering Corp Iodinated acyl derivatives of 2, 4, 6-trhodometa-aminobenzoic acid
GB1033776A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Iodinated acid amides and esters and salts thereof
US3794729A (en) * 1971-07-16 1974-02-26 Schering Corp Inhibiting blood platelet aggregation
CH576255A5 (de) * 1972-11-17 1976-06-15 Bracco Ind Chimica Spa
DE2737802A1 (de) * 1977-08-22 1979-03-08 Henning Berlin Gmbh Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung
DE3037858A1 (de) * 1980-10-07 1982-05-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von reaktiven, kupplungsfaehigen derivaten der schilddruesenhormone t (pfeil abwaerts)3(pfeil abwaerts) und t (pfeil abwaerts)4(pfeil abwaerts) und deren verwendung
CA1327600C (en) * 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
NZ250063A (en) * 1992-12-14 1996-03-26 Eastman Kodak Co Iodinated aromatic acid ester derivatives; x-ray contrast compositions
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x

Also Published As

Publication number Publication date
NO971318L (no) 1997-08-11
NZ292974A (en) 1999-03-29
FI971200A (fi) 1997-05-19
ES2130650T3 (es) 1999-07-01
WO1996009285A1 (en) 1996-03-28
FI971200A0 (fi) 1997-03-21
EP0782565A1 (de) 1997-07-09
AU3529395A (en) 1996-04-09
EP0782565B1 (de) 1999-04-07
GB9419206D0 (en) 1994-11-09
JP3606583B2 (ja) 2005-01-05
EE9700054A (et) 1997-08-15
DE69508949T4 (de) 1999-12-09
DK0782565T3 (da) 1999-10-18
NO971318D0 (no) 1997-03-20
MX9702088A (es) 1997-06-28
US5958376A (en) 1999-09-28
US5958375A (en) 1999-09-28
SK35597A3 (en) 1997-11-05
CA2200752A1 (en) 1996-03-28
GR3030425T3 (en) 1999-09-30
DE69508949T2 (de) 1999-09-09
JPH10505856A (ja) 1998-06-09
PL319367A1 (en) 1997-08-04
HUT77170A (hu) 1998-03-02
CZ89497A3 (en) 1997-09-17
DE69508949D1 (de) 1999-05-12
AU710934B2 (en) 1999-09-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee