MX9702088A - Medios de contraste de rayos x, yodados. - Google Patents

Medios de contraste de rayos x, yodados.

Info

Publication number
MX9702088A
MX9702088A MX9702088A MX9702088A MX9702088A MX 9702088 A MX9702088 A MX 9702088A MX 9702088 A MX9702088 A MX 9702088A MX 9702088 A MX9702088 A MX 9702088A MX 9702088 A MX9702088 A MX 9702088A
Authority
MX
Mexico
Prior art keywords
group
groups
moiety
iodinated
denotes
Prior art date
Application number
MX9702088A
Other languages
English (en)
Other versions
MXPA97002088A (es
Inventor
Anna Rydbeck
Torsten Almen
Mikkel Thaning
Sven Andersson
Lars-Goeran Wistrand
Klaes Golman
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of MXPA97002088A publication Critical patent/MXPA97002088A/es
Publication of MX9702088A publication Critical patent/MX9702088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Liquid Crystal (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)

Abstract

La invencion proporciona los compuestos de bis-fenilo yodados, utiles como agentes de contraste de rayos X, de la formula y (en donde cada porcion C6R5 puede ser la misma o diferente; cada R denota un átomo de hidrogeno o de yodo, o un grupo M, dos o tres grupos R no adyacentes sobre cada porcion C6R5 denotanátomos de yodo y 1, 2 o 3, grupos R sobre cada porcion C6R5 denotan grupos M; X denota un grupo que proporciona una cadena de 1, 2 o 3 átomos que enlazan los dos grupos C6R5, preferentemente donde X es o contiene la cadena que forma el puente, un grupo carboniloxi, siendo cada grupo C6R5 un grupo triyodofenilo o un grupo en el cual cada R es diferente de hidrogeno; y cada M es independientemente una porcion hidrofílica no ionica, M es preferentemente una porcion hidrofílica no ionica que comprende un grupo monohidroxi- o polihidroxi-alquilo) e isomeros, especialmente esteroisomeros y rotámeros de los mismos.
MX9702088A 1994-09-23 1995-09-22 Medios de contraste de rayos x, yodados. MX9702088A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9419206A GB9419206D0 (en) 1994-09-23 1994-09-23 Contrast media
GB9419206.9 1994-09-23
PCT/GB1995/002264 WO1996009285A1 (en) 1994-09-23 1995-09-22 Iodinated x-ray-contrast media

Publications (2)

Publication Number Publication Date
MXPA97002088A MXPA97002088A (es) 1997-06-01
MX9702088A true MX9702088A (es) 1997-06-28

Family

ID=10761799

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702088A MX9702088A (es) 1994-09-23 1995-09-22 Medios de contraste de rayos x, yodados.

Country Status (21)

Country Link
US (2) US5958375A (es)
EP (1) EP0782565B1 (es)
JP (1) JP3606583B2 (es)
AT (1) ATE178592T1 (es)
AU (1) AU710934B2 (es)
CA (1) CA2200752A1 (es)
CZ (1) CZ89497A3 (es)
DE (2) DE69508949T4 (es)
DK (1) DK0782565T3 (es)
EE (1) EE9700054A (es)
ES (1) ES2130650T3 (es)
FI (1) FI971200A (es)
GB (1) GB9419206D0 (es)
GR (1) GR3030425T3 (es)
HU (1) HUT77170A (es)
MX (1) MX9702088A (es)
NO (1) NO971318L (es)
NZ (1) NZ292974A (es)
PL (1) PL319367A1 (es)
SK (1) SK35597A3 (es)
WO (1) WO1996009285A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
ATE298320T1 (de) * 1999-04-30 2005-07-15 Amersham Health As Kontrastmittel
EP1372551B1 (en) 2001-03-08 2008-09-17 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents
EP2471526A3 (en) 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Facially amphiphillic polymers and oligomers and uses thereof
WO2009056555A1 (en) * 2007-10-30 2009-05-07 Ge Healthcare As Contrast agents
US8445725B2 (en) 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
JP5164755B2 (ja) * 2008-09-09 2013-03-21 キヤノン株式会社 ビス−アセチルアミノフェニル化合物の結晶の製造方法
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776241A (en) * 1952-08-06 1957-01-01 Schering Ag Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid
US2708678A (en) * 1954-01-15 1955-05-17 Schering Corp Iodinated acyl derivatives of 2, 4, 6-trhodometa-aminobenzoic acid
GB1033777A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Bis-anilide derivatives
US3794729A (en) * 1971-07-16 1974-02-26 Schering Corp Inhibiting blood platelet aggregation
CH576255A5 (es) * 1972-11-17 1976-06-15 Bracco Ind Chimica Spa
DE2737802A1 (de) * 1977-08-22 1979-03-08 Henning Berlin Gmbh Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung
DE3037858A1 (de) * 1980-10-07 1982-05-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von reaktiven, kupplungsfaehigen derivaten der schilddruesenhormone t (pfeil abwaerts)3(pfeil abwaerts) und t (pfeil abwaerts)4(pfeil abwaerts) und deren verwendung
IE63232B1 (en) * 1987-05-22 1995-04-05 Bracco Int Bv A process for the preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
NZ250063A (en) * 1992-12-14 1996-03-26 Eastman Kodak Co Iodinated aromatic acid ester derivatives; x-ray contrast compositions
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x

Also Published As

Publication number Publication date
EP0782565A1 (en) 1997-07-09
AU3529395A (en) 1996-04-09
ES2130650T3 (es) 1999-07-01
EP0782565B1 (en) 1999-04-07
PL319367A1 (en) 1997-08-04
NZ292974A (en) 1999-03-29
DE69508949D1 (de) 1999-05-12
DE69508949T2 (de) 1999-09-09
JPH10505856A (ja) 1998-06-09
US5958375A (en) 1999-09-28
CA2200752A1 (en) 1996-03-28
WO1996009285A1 (en) 1996-03-28
JP3606583B2 (ja) 2005-01-05
EE9700054A (et) 1997-08-15
DK0782565T3 (da) 1999-10-18
NO971318D0 (no) 1997-03-20
ATE178592T1 (de) 1999-04-15
DE69508949T4 (de) 1999-12-09
FI971200A0 (fi) 1997-03-21
FI971200A (fi) 1997-05-19
GB9419206D0 (en) 1994-11-09
HUT77170A (hu) 1998-03-02
GR3030425T3 (en) 1999-09-30
US5958376A (en) 1999-09-28
NO971318L (no) 1997-08-11
CZ89497A3 (en) 1997-09-17
SK35597A3 (en) 1997-11-05
AU710934B2 (en) 1999-09-30

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