NO960710L - Nye tripeptider nyttige i immun- og CNS-terapi - Google Patents

Nye tripeptider nyttige i immun- og CNS-terapi

Info

Publication number
NO960710L
NO960710L NO960710A NO960710A NO960710L NO 960710 L NO960710 L NO 960710L NO 960710 A NO960710 A NO 960710A NO 960710 A NO960710 A NO 960710A NO 960710 L NO960710 L NO 960710L
Authority
NO
Norway
Prior art keywords
pro
carbon atoms
immune
tripeptides
asp
Prior art date
Application number
NO960710A
Other languages
English (en)
Other versions
NO960710D0 (no
Inventor
Gideon Goldstein
Ponniah Shenbagamurthi
James I Koenig
Original Assignee
Immunobiology Res Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunobiology Res Inst Inc filed Critical Immunobiology Res Inst Inc
Publication of NO960710D0 publication Critical patent/NO960710D0/no
Publication of NO960710L publication Critical patent/NO960710L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det blir fremskaffet tripeptider som er istand til å regulere funksjonen til celler l det mammalske immun- og/eller sentralnervesystemet, farmasøytiske sammen- setninger inneholdende peptldene og fremgangsmåter for anvendelse. Tripeptidene har formelen: R-X-y-Z-KHRj. eller et farmaseytlsk akseptabelt syre- eller baseaddlsjons- salt derav, karakterisert ved at X er D- L-formen av Arg eller desamlno Arg: R er B. en laverealkyl eller laverealkanoyl; 1 er en D- eller L-form av Pro. dehydro-Pro eller hydroksy- Pro; Z er en D- eller L-form av en aminosyre valgt fra Ser, Thr, Asp. Glu, Gin, Aen, beta-Asp, Val eller Ile; og R! er valgt fra gruppen omfattende en rettkjedet eller forgrenet alkyl eller alkenyl med l til 6 karbonatomer. eventuelt substituert med en arylgruppe eller aryl sub- stituert enten med et halogen eller en rettkjedet. forgrenet alkyl eller elkenyl med l til 6 karbonatomer, eller en cykllsk metylengruppe med 3 til 7 karbonatomer.
NO960710A 1993-08-26 1996-02-22 Nye tripeptider nyttige i immun- og CNS-terapi NO960710L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/112,413 US5639729A (en) 1993-08-26 1993-08-26 Tripeptides useful in immune and CNS therapy
PCT/US1994/009290 WO1995005841A1 (en) 1993-08-26 1994-08-17 Novel tripeptides useful in immune and cns therapy

Publications (2)

Publication Number Publication Date
NO960710D0 NO960710D0 (no) 1996-02-22
NO960710L true NO960710L (no) 1996-02-22

Family

ID=22343770

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960710A NO960710L (no) 1993-08-26 1996-02-22 Nye tripeptider nyttige i immun- og CNS-terapi

Country Status (17)

Country Link
US (1) US5639729A (no)
EP (1) EP0723454B1 (no)
JP (1) JPH09502175A (no)
KR (1) KR960703612A (no)
CN (1) CN1133563A (no)
AT (1) ATE207757T1 (no)
BR (1) BR9407357A (no)
CA (1) CA2169072A1 (no)
CZ (1) CZ55496A3 (no)
DE (1) DE69428909D1 (no)
FI (1) FI960839A (no)
HU (1) HUT73777A (no)
IL (1) IL110585A0 (no)
NO (1) NO960710L (no)
PL (1) PL313257A1 (no)
WO (1) WO1995005841A1 (no)
ZA (1) ZA946008B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4727770B2 (ja) * 1997-09-26 2011-07-20 カルピス株式会社 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤
US7605177B2 (en) * 2001-05-24 2009-10-20 Neuren Pharmaceuticals Limited Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
US20070004641A1 (en) * 2001-05-24 2007-01-04 Neuren Pharmaceuticals Limited Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate
US7714020B2 (en) * 2001-05-24 2010-05-11 Neuren Pharmaceuticals Limited Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
ES2325983T3 (es) 2001-05-24 2009-09-28 Neuren Pharmaceuticals Limited Analogos y peptidomimeticos de gpe.
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
US5028592A (en) * 1986-08-08 1991-07-02 Lipton James M Antipyretic and anti-inflammatory peptides
IT1216908B (it) * 1987-03-19 1990-03-14 Eniricerche Spa Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
NZ229004A (en) * 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity
HU201095B (en) * 1988-06-14 1990-09-28 Richter Gedeon Vegyeszet New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions
WO1990003180A1 (en) * 1988-09-30 1990-04-05 Immunobiology Research Institute, Inc. Peptides having t cell suppressor activity
DD296084A5 (de) * 1989-07-27 1991-11-21 Adw Verfahren zur herstellung von humanen spleninderivaten

Also Published As

Publication number Publication date
FI960839A0 (fi) 1996-02-23
HU9600432D0 (en) 1996-04-29
HUT73777A (en) 1996-09-30
NO960710D0 (no) 1996-02-22
ATE207757T1 (de) 2001-11-15
CN1133563A (zh) 1996-10-16
IL110585A0 (en) 1994-11-11
KR960703612A (ko) 1996-08-31
AU682898B2 (en) 1997-10-23
BR9407357A (pt) 1996-10-29
ZA946008B (en) 1995-03-29
CZ55496A3 (en) 1996-08-14
EP0723454B1 (en) 2001-10-31
EP0723454A1 (en) 1996-07-31
AU7868194A (en) 1995-03-21
DE69428909D1 (de) 2001-12-06
CA2169072A1 (en) 1995-03-02
WO1995005841A1 (en) 1995-03-02
EP0723454A4 (en) 1998-07-29
US5639729A (en) 1997-06-17
PL313257A1 (en) 1996-06-24
JPH09502175A (ja) 1997-03-04
FI960839A (fi) 1996-02-23

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