NO954323L - Heterocykliske derivater - Google Patents

Heterocykliske derivater

Info

Publication number
NO954323L
NO954323L NO954323A NO954323A NO954323L NO 954323 L NO954323 L NO 954323L NO 954323 A NO954323 A NO 954323A NO 954323 A NO954323 A NO 954323A NO 954323 L NO954323 L NO 954323L
Authority
NO
Norway
Prior art keywords
alkyl
alkylcarbamoyl
carbamoyl
alkoxycarbonyl
alkoxy
Prior art date
Application number
NO954323A
Other languages
English (en)
Other versions
NO954323D0 (no
Inventor
George Robert Brown
Paul Robert Owen Whittamore
David Robert Brittain
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939308842A external-priority patent/GB9308842D0/en
Priority claimed from GB939324813A external-priority patent/GB9324813D0/en
Priority claimed from GB9402127A external-priority patent/GB9402127D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of NO954323D0 publication Critical patent/NO954323D0/no
Publication of NO954323L publication Critical patent/NO954323L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel (I) hvor R1 er hydrogen eller hydroksy; R2 er hydrogen; eller R1 og R2 er forbundet slik at CR^CR2 er en dobbeltbinding; X er valgt fra -CH2CH2-, -CH=CH-, -C=C-, -CH20-, -OCH2-, -CH2NH-, -NHCH2-, -CH2CO-, -COCH2/ - . CH2S(O)n- og -S(O)nCH2- (hvor n er O, l eller 2); Ar er en ; fenylgruppe som bærer en eller flere substituenter uavhengig av hverandre valgt fra gruppene (l-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkoksy, (1-6C)alkoksykarbonyl, (1-6C)- alkoksykarbonyl(l-6C)alkyl, (1-6C)alkoksy(l-6C)alkyl, (1- 6C)alkylamino, di-[(1-6C)alkyl]amino, karbamoyl, (1-6C)alkyl- karbamoyl, di-[(1-6C)alkyl]karbamoyl, (1-6C)alkanoyl og deres oksimderivater, og O-(1-6C)alkyletere av nevnte oksimer, (1- GOalkyltio, (1-6C) alkylsulf inyl og (1-6C) alkylsulfonyl når substituert med en eller flere grupper valgt fra (1-6C)- alkoksykarbonyl, (1-6C)alkanoyl og deres oksimderivater, og O- (1-6C)alkyletere av nevnte oksimderivater, (1-6C)alkanoyl- amino, (1-6C)alkanoyloksy, (1-6C)alkanoyloksy(1-6C)alkyl, ¿karbamoyl, N-(1-6C)alkylkarbamoyl, N,N-di[(1-6C)alkyl- 'karbamoyl, amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, (1- i 6C)alkoksy, (2-6C)alkenyloksy, (1-6C)alkyltio, (1-6C)alkyl- i sulfinyl, (1-6C)alkylsulfonyl, halogen(1-6C)alkyl, (2-6C)- | alkenyl, (2-6C)alkynyl, fenyl, fenoksy, cyano, nitro, hydroksy l og karboksy; og hvor Ar kan bære ytterligere substituenter; og | deres farmasøytisk akseptable salter som hemmer skvalensyntese og følgelig kan brukes for å senke cholesterolnivået i blod- plasma. Det er også beskrevet fremgangsmåter for fremstilling av forbindelser med formel I så vel som farmasøytiske preparater som inneholder disse forbindelser, og deres anvendelse i medisin.
NO954323A 1993-04-29 1995-10-27 Heterocykliske derivater NO954323L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939308842A GB9308842D0 (en) 1993-04-29 1993-04-29 Heterocyclic derivatives
GB939324813A GB9324813D0 (en) 1993-12-03 1993-12-03 Heterocyclic compounds
GB9402127A GB9402127D0 (en) 1994-02-04 1994-02-04 Heterocyclic derivatives
PCT/GB1994/000910 WO1994025459A1 (en) 1993-04-29 1994-04-28 Heterocyclic derivatives

Publications (2)

Publication Number Publication Date
NO954323D0 NO954323D0 (no) 1995-10-27
NO954323L true NO954323L (no) 1995-12-21

Family

ID=27266674

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954323A NO954323L (no) 1993-04-29 1995-10-27 Heterocykliske derivater

Country Status (11)

Country Link
US (1) US5919793A (no)
EP (1) EP0696284A1 (no)
JP (1) JPH08509488A (no)
CN (1) CN1121718A (no)
AU (1) AU6576494A (no)
CA (1) CA2160795A1 (no)
FI (1) FI955164A0 (no)
GB (1) GB9408473D0 (no)
IL (1) IL109451A0 (no)
NO (1) NO954323L (no)
WO (1) WO1994025459A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737721B1 (fr) * 1995-08-08 1997-09-05 Roussel Uclaf Nouveaux composes biphenyles, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicament et les compositions pharmaceutiques les contenant
EP1217001B1 (en) 1999-09-28 2005-12-07 Eisai Co., Ltd. Quinuclidine compounds and drugs containing the same as the active ingredient
WO2002016357A2 (en) 2000-08-18 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
EP1381603A2 (en) 2000-08-18 2004-01-21 PHARMACIA & UPJOHN COMPANY Quinuclidine-substituedaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
DE60220997T2 (de) 2001-03-27 2008-03-13 Eisai R&D Management Co., Ltd. N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
MXPA04000779A (es) * 2001-08-24 2004-04-20 Pharmacia & Up John Company 7-aza[2.2.1]bicicloheptanos sustituidos con arilo para el tratamiento de enfermedades.
MXPA04007936A (es) 2002-02-15 2004-11-26 Upjohn Co Compuestos de aril-sustituidos para el tratamiento de enfermedades.
TW200305636A (en) * 2002-04-18 2003-11-01 Merck Patent Gmbh Polymerisable compounds comprising a cinnamic acid group and an acetylene group
US7129268B2 (en) * 2002-10-28 2006-10-31 Novo Nordisk A/S Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
EP1745014B1 (en) * 2004-05-05 2011-07-06 High Point Pharmaceuticals, LLC Novel compounds, their preparation and use
ES2347578T3 (es) * 2004-05-05 2010-11-02 High Point Pharmaceuticals, Llc Derivados del acido fenoxiacetico como agonistas de ppar.
WO2007071766A2 (en) 2005-12-22 2007-06-28 Transtech Pharma Phenoxy acetic acids as ppar delta activators
SA08290475B1 (ar) * 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
AU2021312855A1 (en) 2020-07-22 2023-03-09 Reneo Pharmaceuticals, Inc. Crystalline PPAR-delta agonist
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2067534T3 (es) * 1988-04-01 1995-04-01 Sankyo Co Derivados de 2-(heterocicliltio)carbapenemo, su preparacion y su aplicacion como antibioticos.
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
WO1992015579A1 (en) * 1991-03-08 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
GB9201749D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
WO1993021184A1 (en) * 1992-04-10 1993-10-28 Zeneca Limited Biphenylylquinuclidine derivatives as squalene synthase inhibitors
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds

Also Published As

Publication number Publication date
JPH08509488A (ja) 1996-10-08
CA2160795A1 (en) 1994-11-10
NO954323D0 (no) 1995-10-27
FI955164A (fi) 1995-10-27
WO1994025459A1 (en) 1994-11-10
AU6576494A (en) 1994-11-21
EP0696284A1 (en) 1996-02-14
FI955164A0 (fi) 1995-10-27
CN1121718A (zh) 1996-05-01
IL109451A0 (en) 1994-07-31
US5919793A (en) 1999-07-06
GB9408473D0 (en) 1994-06-22

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application