NO952959L - Aza-alifatiske broinneholdende chinolin-2,3-dion - Google Patents

Aza-alifatiske broinneholdende chinolin-2,3-dion

Info

Publication number
NO952959L
NO952959L NO952959A NO952959A NO952959L NO 952959 L NO952959 L NO 952959L NO 952959 A NO952959 A NO 952959A NO 952959 A NO952959 A NO 952959A NO 952959 L NO952959 L NO 952959L
Authority
NO
Norway
Prior art keywords
optionally
stands
esterified
hydroxy
formula
Prior art date
Application number
NO952959A
Other languages
English (en)
Other versions
NO952959D0 (no
Inventor
Robert Moretti
Kaspar Zimmermann
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO952959D0 publication Critical patent/NO952959D0/no
Publication of NO952959L publication Critical patent/NO952959L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Aza-allfatlske broinneholdende chlnoksalln-2,3-dloner ! med formel I, (I) hvor -AI står for laverealkyllden eller en gruppe med formelen >CH-A4-R4 (la), A2 står for laverealkyliden eller en gruppe med formlene >CH-A4-R4 (la) eller >C-0 (lb) eller >CH(OH)-A5-R4 (Ic), A3 står for en ! gruppe med formelen ZN-A^-R5 (Id), A4 står for lavere- !, alkylen, A$ og A£ står uavhengig av hverandre for lave- realkylen eller en direkte binding, n står for O eller l, Rj og R£ står uavhengig av hverandre for hydrogen, 1 i eventuelt med laverealkyl og/eller laverealkanoylsubs- i. tltuert amlno, nltro, laverealkanoyl, eventuelt foret- ret hydroksy, eventuelt forestret karboksy, karbamoyl, 1 cyano, eventuelt halogenert laverealkyl eller halogen, || R3 står for hydrogen eller hydroksy, R4 står eventuelt for forestret eller amldert karboksy, eventuelt for- estret fosfono eller 5-tetrazolyl og RS står for hydro- gen, laverealkyl, laverealkenyl, laverealklnyl, aryl, laverealkanoyl, eventuelt forestret eller amidert kar- boksy, cyano, 5-tetrazolyl, eventuelt foretret eller forestret hydroksy eller dlhydroksylaverealkyl og deres salter, har antagonistiske egenskaper og overfor eksi- tatoriske aminosyre, og kan bil anvendt som antlkonvul- slv og antl-neurodegeneratlve legemiddelvlrkestoffer. Det blir dessuten beskrevet fremgangsmåter for frem- tilllng av disse forbindelsene, farmasøytiske prepa- rater Inneholdende dem samt deres anvendelse som lege- middelvirkestoff .
NO952959A 1994-07-27 1995-07-26 Aza-alifatiske broinneholdende chinolin-2,3-dion NO952959L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH236694 1994-07-27

Publications (2)

Publication Number Publication Date
NO952959D0 NO952959D0 (no) 1995-07-26
NO952959L true NO952959L (no) 1996-01-29

Family

ID=4232111

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952959A NO952959L (no) 1994-07-27 1995-07-26 Aza-alifatiske broinneholdende chinolin-2,3-dion

Country Status (13)

Country Link
EP (1) EP0705834A1 (no)
JP (1) JPH0873465A (no)
KR (1) KR960004346A (no)
CN (1) CN1117493A (no)
AU (1) AU2711695A (no)
BR (1) BR9503458A (no)
CA (1) CA2154624A1 (no)
FI (1) FI953549A (no)
HU (1) HUT73438A (no)
IL (1) IL114729A0 (no)
NO (1) NO952959L (no)
NZ (1) NZ272639A (no)
ZA (1) ZA956209B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063774A (en) * 1996-12-16 2000-05-16 Warner-Lambert Company Tricyclic quinoxaline derivatives as neuroprotective agents
CN1285834A (zh) 1997-11-11 2001-02-28 小野药品工业株式会社 稠合吡嗪化合物
EP2493905B1 (en) 2009-10-26 2016-11-30 Warner Chilcott Company, LLC Bisphosphonate compounds for treating bone metabolism disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK715888D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
JP2955358B2 (ja) * 1989-06-09 1999-10-04 ファルマシア・アンド・アップジョン・カンパニー 中枢神経系活性を有する複素環系アミン
JPH05117276A (ja) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd 新規な３環性キノキサリンジオン誘導体
AU672617B2 (en) * 1992-06-22 1996-10-10 Regents Of The University Of California, The Glycine receptor antagonists and the use thereof
ES2109516T3 (es) * 1992-10-13 1998-01-16 Warner Lambert Co Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores.
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones

Also Published As

Publication number Publication date
BR9503458A (pt) 1996-02-27
FI953549A (fi) 1996-01-28
HU9502240D0 (en) 1995-09-28
CA2154624A1 (en) 1996-01-28
IL114729A0 (en) 1995-11-27
NO952959D0 (no) 1995-07-26
CN1117493A (zh) 1996-02-28
NZ272639A (en) 1997-05-26
HUT73438A (en) 1996-07-29
FI953549A0 (fi) 1995-07-24
AU2711695A (en) 1996-02-08
JPH0873465A (ja) 1996-03-19
EP0705834A1 (de) 1996-04-10
ZA956209B (en) 1996-01-29
KR960004346A (ko) 1996-02-23

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