NO950037L - Fotoaktivering av proteiner for konjugasjonsformat - Google Patents
Fotoaktivering av proteiner for konjugasjonsformatInfo
- Publication number
- NO950037L NO950037L NO950037A NO950037A NO950037L NO 950037 L NO950037 L NO 950037L NO 950037 A NO950037 A NO 950037A NO 950037 A NO950037 A NO 950037A NO 950037 L NO950037 L NO 950037L
- Authority
- NO
- Norway
- Prior art keywords
- photoactivation
- proteins
- reactive
- conjugate
- bonds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Et protein som inneholder en eller flere disulfidbindinger, f.eks. et antistoff blir utsatt for ultrafiolett bestråling for å redusere en eller flere slike bindinger til reaktive sulfhydrylgrupper; det resulterende fotoaktiverte protein blir omsatt med andre kjemiske enheter som er reaktive med sulfhydryl, såsom visse radiometaller, chelaterende midler, legemidler og toksiner slik at det oppnås et konjugat som er nyttig i f.eks. in vitro-diagnose in vivo-billeddan- nelse og terapi.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90826192A | 1992-07-06 | 1992-07-06 | |
PCT/US1993/006388 WO1994001773A1 (en) | 1992-07-06 | 1993-07-06 | Photoactivation of proteins for conjugation purposes |
Publications (2)
Publication Number | Publication Date |
---|---|
NO950037D0 NO950037D0 (no) | 1995-01-05 |
NO950037L true NO950037L (no) | 1995-01-05 |
Family
ID=25425471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO950037A NO950037L (no) | 1992-07-06 | 1995-01-05 | Fotoaktivering av proteiner for konjugasjonsformat |
Country Status (9)
Country | Link |
---|---|
US (1) | US6313274B1 (no) |
EP (1) | EP0649532B1 (no) |
JP (1) | JPH08505119A (no) |
AT (1) | ATE160222T1 (no) |
CA (1) | CA2137561C (no) |
DE (1) | DE69315213T2 (no) |
FI (1) | FI950062A (no) |
NO (1) | NO950037L (no) |
WO (1) | WO1994001773A1 (no) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1057020A2 (de) * | 1998-02-14 | 2000-12-06 | GMD Forschungszentrum Informationstechnik GmbH | Fluoreszenz-energie-transfer für die aufklärung der 3d-struktur von biomakromolekülen |
ATE290879T1 (de) * | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
EP1212465A2 (en) * | 1999-09-15 | 2002-06-12 | Miraibio Inc. | Method for processing biological samples |
US20030017164A1 (en) * | 2001-07-03 | 2003-01-23 | Mallinckrodt Inc. | Dye-azide compounds for dual phototherapy |
US20020169107A1 (en) * | 2001-01-19 | 2002-11-14 | Mallinckrodt Inc. | Novel aromatic azides for type I phototherapy |
GB0019412D0 (en) | 2000-08-08 | 2000-09-27 | Univ York | New imaging agent |
US8697109B2 (en) | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
US7914815B2 (en) | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
US20060083684A1 (en) * | 2002-02-12 | 2006-04-20 | Walton Paul H | Method of radio-labelling biomolecules |
ES2326076T3 (es) * | 2002-12-20 | 2009-09-30 | Mitsubishi Tanabe Pharma Corporation | Procedimiento de proteccion de un grupo tiol en un anticuerpo. |
ATE400602T1 (de) | 2002-12-31 | 2008-07-15 | Nektar Therapeutics Al Corp | Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen |
ATE410450T1 (de) * | 2003-01-22 | 2008-10-15 | Bionanophotonics As | Licht-induzierte immobilisierung |
WO2007000163A1 (en) * | 2005-06-27 | 2007-01-04 | Bionanophotonics A/S | Immobilisation of polypeptides by irradiation |
WO2008077406A2 (en) * | 2006-12-22 | 2008-07-03 | Aalborg Universitet | Coupling of elements |
DE102008010436A1 (de) * | 2008-02-21 | 2009-09-03 | Berthold Technologies Gmbh & Co. Kg | Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen |
US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
CA2639003A1 (en) * | 2008-08-20 | 2010-02-20 | Canadian Blood Services | Inhibition of fc.gamma.r-mediated phagocytosis with reduced immunoglobulin preparations |
WO2010147962A1 (en) | 2009-06-15 | 2010-12-23 | Encore Health, Llc | Choline esters |
PL2442647T3 (pl) | 2009-06-15 | 2016-09-30 | Związki ditiolowe, pochodne i ich zastosowania | |
AU2015227307A1 (en) | 2014-03-03 | 2016-10-13 | Encore Vision, Inc. | Lipoic acid choline ester compositions and methods of use |
CZ309221B6 (cs) * | 2018-09-27 | 2022-06-01 | Mendelova Univerzita V Brně | Způsob identifikace přírodních vzorků, zejména kapalných |
TWI754939B (zh) * | 2020-05-26 | 2022-02-11 | 國立清華大學 | 不可逆共價鍵醣蛋白固定方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4202323A (en) * | 1978-04-28 | 1980-05-13 | Herz Matthew L | Drug activation by radiation |
US4424200A (en) * | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
US4612007A (en) | 1981-06-16 | 1986-09-16 | Edelson Richard Leslie | Method and system for externally treating the blood |
US4867973A (en) | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
US4713326A (en) | 1983-07-05 | 1987-12-15 | Molecular Diagnostics, Inc. | Coupling of nucleic acids to solid support by photochemical methods |
US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
US4689310A (en) | 1984-09-21 | 1987-08-25 | Ortho Diagnostic Systems Inc. | Methods for attaching ligands or anti-ligands to a solid phase |
DE3435744C2 (de) | 1984-09-28 | 1986-08-07 | Organogen Medizinisch-Molekularbiologische Forschungsgesellschaft mbH, 6900 Heidelberg | Trägermaterial zur Verwendung für Immunbestimmungen |
US4597999A (en) | 1984-10-04 | 1986-07-01 | The Hospital For Sick Children | Method for coupling a hydrocarbon containing molecular species |
DE3728599A1 (de) | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
US5061641A (en) | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
EP0354543B1 (en) | 1988-08-08 | 1992-11-11 | Biomira, Inc. | Photochemical attachment of chelating groups to biomolecules |
US5078985A (en) | 1989-08-09 | 1992-01-07 | Rhomed, Incorporated | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
-
1993
- 1993-07-06 AT AT93917002T patent/ATE160222T1/de not_active IP Right Cessation
- 1993-07-06 DE DE69315213T patent/DE69315213T2/de not_active Expired - Fee Related
- 1993-07-06 WO PCT/US1993/006388 patent/WO1994001773A1/en active IP Right Grant
- 1993-07-06 JP JP6503482A patent/JPH08505119A/ja active Pending
- 1993-07-06 EP EP93917002A patent/EP0649532B1/en not_active Expired - Lifetime
- 1993-07-06 CA CA002137561A patent/CA2137561C/en not_active Expired - Fee Related
- 1993-07-06 US US08/362,517 patent/US6313274B1/en not_active Expired - Fee Related
-
1995
- 1995-01-05 FI FI950062A patent/FI950062A/fi unknown
- 1995-01-05 NO NO950037A patent/NO950037L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0649532B1 (en) | 1997-11-12 |
DE69315213D1 (de) | 1997-12-18 |
EP0649532A1 (en) | 1995-04-26 |
JPH08505119A (ja) | 1996-06-04 |
CA2137561C (en) | 2001-10-23 |
US6313274B1 (en) | 2001-11-06 |
FI950062A0 (fi) | 1995-01-05 |
AU4666893A (en) | 1994-01-31 |
FI950062A (fi) | 1995-01-05 |
DE69315213T2 (de) | 1998-03-19 |
WO1994001773A1 (en) | 1994-01-20 |
NO950037D0 (no) | 1995-01-05 |
CA2137561A1 (en) | 1994-01-20 |
AU675235B2 (en) | 1997-01-30 |
ATE160222T1 (de) | 1997-11-15 |
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