NO944121L - Epoksyravsyrederivater - Google Patents

Epoksyravsyrederivater

Info

Publication number
NO944121L
NO944121L NO944121A NO944121A NO944121L NO 944121 L NO944121 L NO 944121L NO 944121 A NO944121 A NO 944121A NO 944121 A NO944121 A NO 944121A NO 944121 L NO944121 L NO 944121L
Authority
NO
Norway
Prior art keywords
group
hydrocarbon residue
optionally substituted
substituted
optionally
Prior art date
Application number
NO944121A
Other languages
English (en)
Other versions
NO944121D0 (no
Inventor
Shigetoshi Tsubotani
Masayuki Takizawa
Mikio Shirasaki
Yukio Fujisawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO944121D0 publication Critical patent/NO944121D0/no
Publication of NO944121L publication Critical patent/NO944121L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En forbindelse med den generelle formel:. hvor. Rstår for en karbokeylgruppe som eventuelt kan være esterifisert eller amldert;. Rstår for en cykllsk gruppe som eventuelt kan være substituert eller en polar gruppe;. n er et helt tall på 0 til 6;. Rstår for hydrogen eller en hydrokarbonrest som eventuelt kan være substituert;. Rstår for (1) en hydrokarbonrest som kan være substituert med en eventuelt beskyttet amlnogruppe eller (2) en alkenylgruppe; eller. Rog Rkan være kombinert med det hosllggende nltrogenatom for å danne en heterocykllsk gruppe Inneholdende minst to heteroatomer, eller et salt derav.Forbindelsene eller deres salter hemmer tlolprotease slik som catepsin L og B og tjener så vel som pro-fylaktisk som terapeutisk middel for bensykdommer slik osteoporose.
NO944121A 1993-10-29 1994-10-28 Epoksyravsyrederivater NO944121L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27283593 1993-10-29
JP27280693 1993-10-29
JP18616594 1994-08-08

Publications (2)

Publication Number Publication Date
NO944121D0 NO944121D0 (no) 1994-10-28
NO944121L true NO944121L (no) 1995-05-02

Family

ID=27325696

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944121A NO944121L (no) 1993-10-29 1994-10-28 Epoksyravsyrederivater

Country Status (9)

Country Link
US (1) US5556853A (no)
EP (1) EP0655447A1 (no)
KR (1) KR950011429A (no)
CN (1) CN1112555A (no)
AU (1) AU7755294A (no)
CA (1) CA2134627A1 (no)
FI (1) FI945092A (no)
HU (1) HUT72319A (no)
NO (1) NO944121L (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2537695A (en) * 1994-05-31 1995-12-21 Takeda Chemical Industries Ltd. Epoxysuccinic acid derivatives, their production and use
WO1997003060A1 (fr) * 1995-07-13 1997-01-30 Senju Pharmaceutical Co., Ltd. Derives de la piperazine et leurs utilisations
EP0808839B1 (en) * 1995-12-12 2001-05-23 Taiho Pharmaceutical Co., Ltd. Epoxysuccinamide derivatives or salts thereof, and drugs containing the same
DE69814800T2 (de) * 1997-04-18 2003-12-18 Taiho Pharmaceutical Co Ltd Epoxysuccinamid-derivate oder ihre salze
DE69815137T2 (de) * 1997-09-04 2004-04-08 Nippon Chemiphar Co. Ltd. Epoxybernsteinsäureamid-derivate
US7132539B2 (en) * 2002-10-23 2006-11-07 The Procter & Gamble Company Melanocortin receptor ligands
WO2007038772A1 (en) * 2005-09-28 2007-04-05 American Life Science Pharmaceuticals Novel drugs for dementia
AU2007305138A1 (en) * 2006-06-13 2008-04-10 The Board Of Trustees Of The Leland Stanford Junior University Epoxide inhibitors of cysteine proteases
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease
US20100331545A1 (en) * 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
CN107151236B (zh) 2016-03-03 2021-04-30 中国人民解放军军事医学科学院毒物药物研究所 一种2,3-环氧丁二酰衍生物及其制备方法和用途
CN113387909B (zh) * 2020-03-13 2023-11-14 中国人民解放军军事科学院军事医学研究院 2,3-环氧丁二酰衍生物的医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55115878A (en) * 1979-02-27 1980-09-06 Taisho Pharmaceut Co Ltd Epoxysuccinic acid derivative
JPS55153778A (en) * 1979-05-17 1980-11-29 Taisho Pharmaceut Co Ltd Epoxysuccinylamino acid derivative
JPS5772913A (en) * 1980-10-22 1982-05-07 Nippon Chemiphar Co Ltd Remedy for cardiac infraction
JPS57169478A (en) * 1981-04-10 1982-10-19 Nippon Chemiphar Co Ltd Piperazine derivative
JPS5855478A (ja) * 1981-09-25 1983-04-01 Nippon Chemiphar Co Ltd エチレンジアミン誘導体と，心筋梗塞の予防および治療剤
JPS58126879A (ja) * 1982-01-25 1983-07-28 Nippon Chemiphar Co Ltd 光学活性なピペラジン誘導体ならびに心筋梗塞の予防および治療剤
JPS608223A (ja) * 1983-06-28 1985-01-17 Taisho Pharmaceut Co Ltd 抗アレルギ−剤
EP0269311A3 (en) * 1986-11-17 1990-06-06 Merck & Co. Inc. Methods of treating bone diseases by administration of a cysteine proteinase inhibitor
JPH02218610A (ja) * 1989-02-21 1990-08-31 Toyo Jozo Co Ltd 骨疾患の予防および治療剤
JPH02304074A (ja) * 1989-05-18 1990-12-17 Taisho Pharmaceut Co Ltd エポキシコハク酸誘導体

Also Published As

Publication number Publication date
HUT72319A (en) 1996-04-29
US5556853A (en) 1996-09-17
AU7755294A (en) 1995-05-18
FI945092A0 (fi) 1994-10-28
HU9403116D0 (en) 1994-12-28
EP0655447A1 (en) 1995-05-31
FI945092A (fi) 1995-04-30
CN1112555A (zh) 1995-11-29
KR950011429A (ko) 1995-05-15
NO944121D0 (no) 1994-10-28
CA2134627A1 (en) 1995-04-30

Similar Documents

Publication Publication Date Title
NO944121L (no) Epoksyravsyrederivater
TW200407309A (en) 1,2-Azole derivatives
SG159380A1 (en) Heteroaryl compounds useful as inhibitors of gsk-3
DK1325910T3 (da) Aliphatiske nitrogenholdige femleddede ringforbindelser
CA2203942A1 (en) A pyrrolidylthiocarbapenem derivative
EA200601830A1 (ru) Ортозамещённые арильные или гетероарильные амидные соединения
DK1008592T3 (da) Cykliske amidderivater, som inhiberer cathepsin K
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
EP1241528A3 (en) Radical polymerizable compounds for image forming materials
DK0915859T3 (da) Visse substituerede benzylaminderivater; en ny klasse af Neuropeptid Y1-specifikke ligander
NO20060703L (no) Fremgangsmate for fremstilling av cis-4-fluor-1-prolinderivater
TW245716B (no)
GR3006247T3 (no)
IL116401A0 (en) Amid s of ono a d dic rboxy ic acids with aminoalcohols selectively active on the cannabinoid peripheral receptor
HK1036802A1 (en) Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
NO20002589L (no) Bifenylamidinderivater
EA200200108A1 (ru) Производные стрептограминов, способ их получения и композиции на их основе
DE602004003948D1 (de) Herstellung von 2-18f-2-desoxy-d-glucose durch festphasensynthese
YU3099A (sh) Novi derivati eritromicina, postupak za njihovo dobijanje i njihova primena
EA199900528A1 (ru) Новые производные эритромицина, способ их получения и применения в качетве медикаментов
NO993124L (no) Nye erytromycinderivater, fremgangsmåte for fremstilling av disse samt deres anvendelse som medisiner
AP2001002314A0 (en) Substituted benzolactam compounds.
MY136065A (en) Prodrugs to nmda receptor ligands
BG101287A (en) Microbicidal composition
ES2060545A1 (es) Un procedimiento para producir un derivado de benzo(b)tiofen-5-ilo opticamente activo.