NO943739L - Vaksiner inneholdende vesikler basert på ikke-ioniske overflate-aktive midler - Google Patents
Vaksiner inneholdende vesikler basert på ikke-ioniske overflate-aktive midlerInfo
- Publication number
- NO943739L NO943739L NO943739A NO943739A NO943739L NO 943739 L NO943739 L NO 943739L NO 943739 A NO943739 A NO 943739A NO 943739 A NO943739 A NO 943739A NO 943739 L NO943739 L NO 943739L
- Authority
- NO
- Norway
- Prior art keywords
- nonionic surfactants
- vesicles
- vaccines containing
- containing vesicles
- vesicles based
- Prior art date
Links
- 239000002736 nonionic surfactant Substances 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- QHZLMUACJMDIAE-UHFFFAOYSA-N 1-monopalmitoylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 150000002314 glycerols Chemical class 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/45—Toxoplasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Vesikler basert på ikke-ioniske overflate-aktive midler (NSIV) med innesluttet antigen, virker som potente immuno- logiske adjuvanser og kan frembringe antistoff-titere av samme størrelsesorden som de hvor Freunds' komplette adjuvans benyttes. Oppfinnelsen tilveiebringer vaksiner som omfatter slike vesikler. Fortrinnsvis er de ikke-ioniske overflate- aktive midlene glycerolestere, særlig 1-monopalmitoylglycerol. Vesiklene kan administreres ved injeksjon eller via slim- hinner, hvorav peroral administrering foretrekkes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929207731A GB9207731D0 (en) | 1992-04-07 | 1992-04-07 | Improvements in or relating to vaccines |
PCT/GB1993/000716 WO1993019781A1 (en) | 1992-04-07 | 1993-04-06 | Vaccines containing non-ionic surfactant vesicles |
Publications (2)
Publication Number | Publication Date |
---|---|
NO943739D0 NO943739D0 (no) | 1994-10-05 |
NO943739L true NO943739L (no) | 1994-10-05 |
Family
ID=10713695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO943739A NO943739L (no) | 1992-04-07 | 1994-10-05 | Vaksiner inneholdende vesikler basert på ikke-ioniske overflate-aktive midler |
Country Status (16)
Country | Link |
---|---|
US (1) | US5679355A (no) |
EP (1) | EP0634937B1 (no) |
JP (1) | JP2690620B2 (no) |
KR (1) | KR950700758A (no) |
CN (1) | CN1085449A (no) |
AT (1) | ATE158185T1 (no) |
AU (1) | AU3899793A (no) |
CA (1) | CA2132547C (no) |
DE (1) | DE69314020T2 (no) |
FI (1) | FI944676A0 (no) |
GB (1) | GB9207731D0 (no) |
HU (1) | HUT69935A (no) |
NO (1) | NO943739L (no) |
NZ (1) | NZ251402A (no) |
WO (1) | WO1993019781A1 (no) |
ZA (1) | ZA932491B (no) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995003035A1 (en) * | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Polymerized liposomes with enhanced stability for oral delivery |
US5919466A (en) * | 1993-10-01 | 1999-07-06 | Gerbu Biotechnik Gmbh | Method for improving the yield of immunoantibodies in the vaccination of animals and humans |
GB9320597D0 (en) * | 1993-10-06 | 1993-11-24 | Proteus Molecular Design | Improvements in and realting to vaccines |
JPH09510433A (ja) * | 1993-12-17 | 1997-10-21 | マイクロパック インコーポレイテッド | 生物学的に活性な物質を細胞に送達する方法 |
US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
GB9515868D0 (en) * | 1995-08-02 | 1995-10-04 | Proteus Molecular Design | Therapeutic method |
GB9600471D0 (en) * | 1996-01-10 | 1996-03-13 | Univ London Pharmacy | Drug delivery system |
WO1999052549A1 (en) * | 1998-04-09 | 1999-10-21 | Smithkline Beecham Biologicals S.A. | Adjuvant compositions |
US6494865B1 (en) * | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
FR2802422B1 (fr) * | 1999-12-21 | 2002-08-09 | Capsulis | Structures mixtes resultant de l'incorporation d'une macromolecule biologique, en particulier d'adn, dans une phase structuree d'amphiphiles et vesicules obtenues a partir de ces structures |
GB9930591D0 (en) * | 1999-12-23 | 2000-02-16 | Univ London | Component for vaccine |
FI112825B (fi) * | 2001-07-11 | 2004-01-15 | Antti Nissinen | Menetelmä alkoholinkulutuksen osoittamiseksi, menetelmässä käytettäviä välineitä sekä niiden valmistus |
US20040208920A1 (en) * | 2002-07-03 | 2004-10-21 | Dov Michaeli | Liposomal vaccine |
WO2004045583A1 (ja) * | 2002-11-15 | 2004-06-03 | Nipro Corporation | リポソーム |
FR2850872A1 (fr) * | 2003-02-12 | 2004-08-13 | Ethypharm Sa | Composition vaccinale destinee a induire une reponse immunitaire contre le virus responsable du sida |
CN100509072C (zh) | 2003-08-28 | 2009-07-08 | 贝克顿·迪金森公司 | 皮内注射装置 |
US8202523B2 (en) * | 2005-09-22 | 2012-06-19 | ProSci, Inc. | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
KR101701198B1 (ko) | 2008-06-19 | 2017-02-01 | 배리에이션 바이오테크놀로지스 아이엔씨. | 인플루엔자를 치료하기 위한 조성물 및 방법 |
WO2010014686A1 (en) | 2008-07-30 | 2010-02-04 | Aleva Neurotherapeutics, S.A. | Apparatus and method for optimized stimulation of a neurological target |
WO2010055421A1 (en) | 2008-11-12 | 2010-05-20 | Aleva Neurotherapeutics, S.A. | Microfabricated neurostimulation device |
CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
WO2011067297A1 (en) | 2009-12-01 | 2011-06-09 | ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE | Microfabricated neurostimulation device and methods of making and using the same |
US9549708B2 (en) | 2010-04-01 | 2017-01-24 | Ecole Polytechnique Federale De Lausanne | Device for interacting with neurological tissue and methods of making and using the same |
US9238796B2 (en) | 2010-06-04 | 2016-01-19 | Toagosei Co. Ltd. | Cell growth-promoting peptide and use thereof |
AU2011276223C1 (en) | 2010-07-06 | 2016-05-12 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
WO2012093732A1 (ja) * | 2011-01-07 | 2012-07-12 | セイコーエプソン株式会社 | アミロイド前駆体タンパク質のシグナルペプチドに対する抗体 |
US9506933B2 (en) | 2011-01-07 | 2016-11-29 | Toagosei Co., Ltd. | Method of preparing antigen for acquiring anti-hydrophobic peptide antibody |
MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
EP2663288B1 (en) * | 2011-01-13 | 2022-12-21 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
CN104302323A (zh) | 2012-01-12 | 2015-01-21 | 变异生物技术公司 | 用于治疗病毒感染的组合物和方法 |
RU2698906C2 (ru) * | 2012-01-27 | 2019-09-02 | Вэриэйшн Биотекнолоджиз, Инк. | Способы и композиции для терапевтических агентов |
JP6066222B2 (ja) | 2012-05-28 | 2017-01-25 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
WO2014061749A1 (ja) | 2012-10-18 | 2014-04-24 | 東亞合成株式会社 | 2型tnf受容体の発現を抑制する合成ペプチド及びその利用 |
US11311718B2 (en) | 2014-05-16 | 2022-04-26 | Aleva Neurotherapeutics Sa | Device for interacting with neurological tissue and methods of making and using the same |
WO2015173787A1 (en) | 2014-05-16 | 2015-11-19 | Aleva Neurotherapeutics Sa | Device for interacting with neurological tissue and methods of making and using the same |
US9474894B2 (en) | 2014-08-27 | 2016-10-25 | Aleva Neurotherapeutics | Deep brain stimulation lead |
US9403011B2 (en) | 2014-08-27 | 2016-08-02 | Aleva Neurotherapeutics | Leadless neurostimulator |
WO2017134587A1 (en) | 2016-02-02 | 2017-08-10 | Aleva Neurotherapeutics, Sa | Treatment of autoimmune diseases with deep brain stimulation |
GB201612108D0 (en) * | 2016-07-12 | 2016-08-24 | Univ Strathclyde | Preperation of non-ionic surfactant vesicles and variants |
US10702692B2 (en) | 2018-03-02 | 2020-07-07 | Aleva Neurotherapeutics | Neurostimulation device |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2408387A2 (fr) * | 1975-06-30 | 1979-06-08 | Oreal | Compositions a base de dispersions aqueuses de spherules lipidiques |
FR2571963B1 (fr) * | 1984-10-24 | 1987-07-10 | Oreal | Composition a usage cosmetique ou pharmaceutique contenant des niosomes et au moins un polyamide hydrosoluble et procede de preparation de cette composition. |
SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
FR2597346B1 (fr) * | 1986-04-22 | 1989-08-18 | Oreal | Procede pour faciliter la formation de niosomes en dispersion dans une phase aqueuse et pour ameliorer leur stabilite et leur taux d'encapsulation, et dispersions correspondantes. |
US4855090A (en) * | 1987-03-13 | 1989-08-08 | Micro-Pak, Inc. | Method of producing high aqueous volume multilamellar vesicles |
EP0349579B1 (en) * | 1987-03-13 | 1992-01-08 | Micro Vesicular Systems, Inc. | Lipid vesicles formed of surfactants and steroids |
GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
LU87449A1 (fr) * | 1989-02-09 | 1990-09-19 | Oreal | Procede de fabrication de mousses utilisables dans les domaines cosmetique et pharmaceutique et mousses obtenues par ce procede |
IT1238343B (it) * | 1989-10-16 | 1993-07-13 | Cesalpino Andrea Fond | Procedimento per la preparazione di vaccini capaci di generare non solo la risposta immune dei linfociti t helper,ma anche un'efficace risposta di linfociti t citotossici,e vaccini con queste caratteristiche |
EP0577751B1 (en) * | 1991-03-28 | 1998-11-11 | Micro-Pak, Inc. | Lipid vesicle containing water-in-oil emulsions |
-
1992
- 1992-04-07 GB GB929207731A patent/GB9207731D0/en active Pending
-
1993
- 1993-04-06 NZ NZ251402A patent/NZ251402A/en unknown
- 1993-04-06 US US08/302,915 patent/US5679355A/en not_active Expired - Fee Related
- 1993-04-06 AU AU38997/93A patent/AU3899793A/en not_active Abandoned
- 1993-04-06 EP EP93908000A patent/EP0634937B1/en not_active Expired - Lifetime
- 1993-04-06 HU HU9402904A patent/HUT69935A/hu unknown
- 1993-04-06 WO PCT/GB1993/000716 patent/WO1993019781A1/en active IP Right Grant
- 1993-04-06 AT AT93908000T patent/ATE158185T1/de active
- 1993-04-06 JP JP5517269A patent/JP2690620B2/ja not_active Expired - Fee Related
- 1993-04-06 DE DE69314020T patent/DE69314020T2/de not_active Expired - Fee Related
- 1993-04-06 CA CA002132547A patent/CA2132547C/en not_active Expired - Fee Related
- 1993-04-07 ZA ZA932491A patent/ZA932491B/xx unknown
- 1993-04-07 CN CN93105224A patent/CN1085449A/zh active Pending
-
1994
- 1994-10-05 NO NO943739A patent/NO943739L/no unknown
- 1994-10-06 FI FI944676A patent/FI944676A0/fi not_active Application Discontinuation
- 1994-10-07 KR KR1019940703545A patent/KR950700758A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR950700758A (ko) | 1995-02-20 |
NO943739D0 (no) | 1994-10-05 |
NZ251402A (en) | 1996-10-28 |
ATE158185T1 (de) | 1997-10-15 |
JPH07505389A (ja) | 1995-06-15 |
US5679355A (en) | 1997-10-21 |
HUT69935A (en) | 1995-09-28 |
CA2132547C (en) | 2000-06-06 |
FI944676A (fi) | 1994-10-06 |
AU3899793A (en) | 1993-11-08 |
HU9402904D0 (en) | 1995-01-30 |
DE69314020T2 (de) | 1998-08-06 |
GB9207731D0 (en) | 1992-05-27 |
EP0634937B1 (en) | 1997-09-17 |
JP2690620B2 (ja) | 1997-12-10 |
WO1993019781A1 (en) | 1993-10-14 |
CA2132547A1 (en) | 1993-10-14 |
EP0634937A1 (en) | 1995-01-25 |
ZA932491B (en) | 1993-11-02 |
DE69314020D1 (de) | 1997-10-23 |
CN1085449A (zh) | 1994-04-20 |
FI944676A0 (fi) | 1994-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO943739L (no) | Vaksiner inneholdende vesikler basert på ikke-ioniske overflate-aktive midler | |
UA40597C2 (uk) | Вакцинна композиція,спосіб лікування ссавців, що страждають або сприйнятливі до інфекції, спосіб лікування ссавців, що страждають на рак, спосіб одержання вакцинної композиції, композиція ад'ювантів | |
FI951535A0 (fi) | Immunogeeninen meningokokki -LPS ja siitä saadut ulkomembraanirakkulat ja rokote | |
NO912369D0 (no) | Meningokokk-klasse-1-ytre-membranvaksine. | |
EP0835663A3 (en) | Combined vaccines comprising Hepatitis B surface antigen and other antigens | |
MY134811A (en) | A vaccine composition comprising an antigen, a saponin and a sterol | |
AU1934088A (en) | Saponin adjuvant | |
ATE153071T1 (de) | Neue proteinhaltige partikeln | |
KR970703164A (ko) | 헬리코박터류 감염의 치료 및 예방용 항원 제제(treatment and prevention of helicobacter infection) | |
FI924457A (fi) | Kompositioner och behandlingsfoerfarande foer lunginflammation i djur | |
NZ331557A (en) | Porphyromonas gingivalis antigens for the diagnosis and treatment of periodontitis | |
DE69527986D1 (de) | Antigene arznei zur behandlung oder vorbeugung | |
NO175846C (no) | Fremgangsmåte for å oppnå et immunogen | |
ATE185073T1 (de) | Impfstoff zubereitungen | |
KR930700544A (ko) | 열대열말라리아원충의 16kDa의 표면 단백질 | |
CA2273922A1 (en) | Novel saponin compositions and uses thereof | |
CA2133108A1 (en) | Pasteurella haemolytica type a-1 bacterin-toxoid vaccine | |
CA2133441A1 (en) | Haemophilus somnus immunogenic proteins | |
DE69322960T2 (de) | Empfängnisverhütender impfstoff | |
IT8821666A0 (it) | Coniugato peptidico immunologicamente attivo utile come vaccino antimalaria e metodo di immunizzazione impiegante lo stesso | |
MX9710523A (es) | Vacunas contra hepatitis c. | |
TH32433A (th) | " วัคซีน " |