NO943723L - Anvendelse av kinolin-3-karboksamidforbindelser for behandling av diabetes - Google Patents

Anvendelse av kinolin-3-karboksamidforbindelser for behandling av diabetes

Info

Publication number
NO943723L
NO943723L NO943723A NO943723A NO943723L NO 943723 L NO943723 L NO 943723L NO 943723 A NO943723 A NO 943723A NO 943723 A NO943723 A NO 943723A NO 943723 L NO943723 L NO 943723L
Authority
NO
Norway
Prior art keywords
diabetes
quinoline
hydrogen atoms
treatment
compound
Prior art date
Application number
NO943723A
Other languages
English (en)
Other versions
NO943723D0 (no
Inventor
Shimon Slavin
Lola Weiss
David Gross
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of NO943723L publication Critical patent/NO943723L/no
Publication of NO943723D0 publication Critical patent/NO943723D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Anvendelse av en anti-diabetisk kinolin-3-karboks- amidforbindelse omfattende struktur (I), eventuelt med substituenter for de angitte hydrogenatomer (H1"9), eller et salt av nevnte forbindelse (D hvor (a) ----- representerer at det er to konjugerte dobbeltbindinger mellom atomene innbefattet av den stiplede linje, (b) X^ og X2 er hver valgt blant et oksygenatom eller en NH9-gruppe, idet Xx og X2 er bundet med en enkeltbinding til ringen når de er knyttet til H7 eller H8 og med en dobbeltbinding når de ikke er bundet til H7 og H8, (c) H1'9 er hydrogen- atomer, med det forbehold at H9 bare er nærværende når minst en av Xx eller X2 er en NH9-gruppe, (d) H7 og H8 er hydrogenatomer som er knyttet til forskjel- lige atomer valgt blant xlf X2 og nitrogenatomet (N) i kinolinringen, for fremstilling av en sammensetning som er beregnet på behandling av tilstander forbundet med diabetes av type I. Også beskrevet er behand- lingsmetoder for diabetes, i hvilke metoder disse forbindelser administreres til en pasient. En spesi- elt foretrukken forbindelse er N-metyl-l,2-dihydro-4- hydroksy-l-metyl-2-oksokinolin-3-karboksamid eller et salt derav.
NO943723A 1992-04-06 1994-10-05 Anvendelse av kinolin-3-karboksamidforbindelser for behandling av diabetes NO943723D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9201076A SE9201076L (sv) 1992-04-06 1992-04-06 Användningen av gamla läkemedel för behandling av diabetes
PCT/SE1993/000272 WO1993019756A1 (en) 1992-04-06 1993-03-31 The use of quinoline-3-carboxamide compounds for treatment of diabetes

Publications (2)

Publication Number Publication Date
NO943723L true NO943723L (no) 1994-10-05
NO943723D0 NO943723D0 (no) 1994-10-05

Family

ID=20385863

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943723A NO943723D0 (no) 1992-04-06 1994-10-05 Anvendelse av kinolin-3-karboksamidforbindelser for behandling av diabetes

Country Status (16)

Country Link
US (1) US5594005A (no)
EP (1) EP0634931A1 (no)
JP (1) JPH07506568A (no)
KR (1) KR950700738A (no)
CN (1) CN1081671A (no)
AU (1) AU667362B2 (no)
CA (1) CA2131831C (no)
EE (1) EE03090B1 (no)
HU (1) HUT69710A (no)
IL (1) IL105285A0 (no)
NO (1) NO943723D0 (no)
NZ (1) NZ251494A (no)
PH (1) PH30820A (no)
SE (1) SE9201076L (no)
WO (1) WO1993019756A1 (no)
ZA (1) ZA932450B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133285A (en) * 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
SE9802549D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
SE9802550D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
FR2827600A1 (fr) * 2001-07-20 2003-01-24 Lipha Derives acides de quinolone et leurs applications en therapeutique
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
CN102176906B (zh) * 2008-10-09 2014-07-02 新树株式会社 Panduratin衍生物或提琴形凹唇姜提取物的全新用途
MX2013004169A (es) 2010-10-14 2013-06-05 Immunahr Ab 1, 2-dihidro-4-hidroxi-2-oxo-quinolina-3-carboxanilidas como activadores del receptor de hidrocarburo aromatico.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1034124A (en) * 1973-05-11 1978-07-04 Ciba-Geigy Ag Process for the manufacture of new quinolines
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
DE3134780A1 (de) * 1981-09-02 1983-03-10 Hoechst Ag, 6000 Frankfurt "sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung"
US5310913A (en) * 1989-06-09 1994-05-10 Kabi Pharmacia Aktiebolag Derivatives of quinoline-3-carboxanilide
SE9000624D0 (sv) * 1990-02-22 1990-02-22 Pharmacia Ab New use
SE9001111D0 (sv) * 1990-03-27 1990-03-27 Pharmacia Ab Supportive use

Also Published As

Publication number Publication date
SE9201076L (sv) 1993-10-07
HUT69710A (en) 1995-09-28
CN1081671A (zh) 1994-02-09
EE03090B1 (et) 1998-06-15
NZ251494A (en) 1997-07-27
KR950700738A (ko) 1995-02-20
JPH07506568A (ja) 1995-07-20
US5594005A (en) 1997-01-14
CA2131831C (en) 1999-03-09
PH30820A (en) 1997-10-17
EP0634931A1 (en) 1995-01-25
AU667362B2 (en) 1996-03-21
AU3913193A (en) 1993-11-08
SE9201076D0 (sv) 1992-04-06
ZA932450B (en) 1993-10-20
WO1993019756A1 (en) 1993-10-14
CA2131831A1 (en) 1993-10-14
HU9402854D0 (en) 1995-01-30
IL105285A0 (en) 1993-08-18
NO943723D0 (no) 1994-10-05

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