NO942299D0 - Stabilisert, farmasöytisk preparat som omfatter veksthormon og asparagin - Google Patents
Stabilisert, farmasöytisk preparat som omfatter veksthormon og asparaginInfo
- Publication number
- NO942299D0 NO942299D0 NO942299A NO942299A NO942299D0 NO 942299 D0 NO942299 D0 NO 942299D0 NO 942299 A NO942299 A NO 942299A NO 942299 A NO942299 A NO 942299A NO 942299 D0 NO942299 D0 NO 942299D0
- Authority
- NO
- Norway
- Prior art keywords
- growth hormone
- asparagine
- pharmaceutical preparation
- stabilized pharmaceutical
- dissolved
- Prior art date
Links
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 title abstract 2
- 229960001230 asparagine Drugs 0.000 title abstract 2
- 235000009582 asparagine Nutrition 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK912047A DK204791D0 (da) | 1991-12-20 | 1991-12-20 | Hidtil ukendt farmaceutisk praeparat |
| PCT/DK1992/000378 WO1993012811A1 (en) | 1991-12-20 | 1992-12-16 | A stabilized pharmaceutical formulation comprising growth hormone and asparagine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO942299D0 true NO942299D0 (no) | 1994-06-17 |
| NO942299L NO942299L (no) | 1994-06-17 |
Family
ID=8109696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO942299A NO942299L (no) | 1991-12-20 | 1994-06-17 | Stabilisert, farmasöytisk preparat som omfatter veksthormon og asparagin |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5977069A (fi) |
| EP (1) | EP0618806B1 (fi) |
| JP (1) | JP3662580B2 (fi) |
| KR (1) | KR100270726B1 (fi) |
| AT (1) | ATE177645T1 (fi) |
| AU (1) | AU664416B2 (fi) |
| BG (1) | BG98804A (fi) |
| CA (1) | CA2125856A1 (fi) |
| CZ (1) | CZ282826B6 (fi) |
| DE (1) | DE69228704T2 (fi) |
| DK (1) | DK204791D0 (fi) |
| FI (1) | FI942905A (fi) |
| HU (1) | HUT69682A (fi) |
| NO (1) | NO942299L (fi) |
| NZ (1) | NZ246555A (fi) |
| RO (1) | RO112086B1 (fi) |
| RU (1) | RU2098130C1 (fi) |
| SK (1) | SK73794A3 (fi) |
| WO (1) | WO1993012811A1 (fi) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5849704A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
| US5849700A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| US5652216A (en) * | 1994-05-26 | 1997-07-29 | Novo Nordisk A/S | Pharmaceutical preparation |
| US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5654278A (en) * | 1994-10-13 | 1997-08-05 | Novo Nordisk A/S | Composition and method comprising growth hormone and leucine |
| JPH10511964A (ja) * | 1995-01-13 | 1998-11-17 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン及びＸ−Ｌｙｓを含む安定化医薬製剤 |
| US5705482A (en) * | 1995-01-13 | 1998-01-06 | Novo Nordisk A/S | Pharmaceutical formulation |
| ZA96122B (en) * | 1995-01-13 | 1996-07-24 | Novo Nordisk As | A pharmaceutical formulation |
| US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
| ZA965367B (en) * | 1995-07-12 | 1997-01-23 | Novo Nordisk As | A pharmaceutical formulation |
| EP0858803A4 (en) * | 1995-08-28 | 2000-02-09 | Showa Pharm Chem Ind | COMPOSITION FOR LOCAL ANESTHESIA |
| US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| PT934061E (pt) | 1996-07-24 | 2003-10-31 | Warner Lambert Co | Isobutilgaba e seus derivados para o tratamento da dor |
| US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
| MXPA03001092A (es) * | 2000-08-07 | 2003-09-25 | Nektar Therapeutics Al Corp | Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada. |
| US7271150B2 (en) * | 2001-05-14 | 2007-09-18 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified growth hormone |
| RU2234945C2 (ru) * | 2002-10-15 | 2004-08-27 | Вардосанидзе Ирина Викторовна | Стабилизатор водного раствора и водосодержащего сырья с самопроизвольно изменяющимися окислительно-восстановительными свойствами |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| CA2671850A1 (en) * | 2006-12-08 | 2008-06-19 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
| US20160015789A1 (en) * | 2014-07-17 | 2016-01-21 | Teva Pharmaceutical Industries, Ltd. | FORMULATIONS OF AN ALBUMIN hGH FUSION PROTEIN |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| ES2044941T5 (es) * | 1987-08-21 | 1999-02-16 | Mallinckrodt Group Inc | Estabilizador de hormonas promotoras del crecimiento. |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| US5122512A (en) * | 1988-09-12 | 1992-06-16 | Pitman-Moore, Inc. | Swine growth promoting composition |
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| ES2185625T3 (es) * | 1991-12-20 | 2003-05-01 | Novo Nordisk As | Formulacion farmaceutica estabilizada que incluye hormona de crecimiento e histidina. |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| MD1699F2 (ro) * | 1992-07-31 | 2001-07-31 | Genentech, Inc. | Compoziţie apoasă a hormonului somatotrop uman şi procedeu de prevenire a denaturării ei |
| US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
-
1991
- 1991-12-20 DK DK912047A patent/DK204791D0/da not_active Application Discontinuation
-
1992
- 1992-01-28 US US07/827,178 patent/US5977069A/en not_active Expired - Fee Related
- 1992-12-16 AU AU33445/93A patent/AU664416B2/en not_active Ceased
- 1992-12-16 SK SK737-94A patent/SK73794A3/sk unknown
- 1992-12-16 RU RU9494045921A patent/RU2098130C1/ru active
- 1992-12-16 DE DE69228704T patent/DE69228704T2/de not_active Expired - Fee Related
- 1992-12-16 EP EP93902088A patent/EP0618806B1/en not_active Expired - Lifetime
- 1992-12-16 JP JP51136093A patent/JP3662580B2/ja not_active Expired - Fee Related
- 1992-12-16 WO PCT/DK1992/000378 patent/WO1993012811A1/en active IP Right Grant
- 1992-12-16 NZ NZ246555A patent/NZ246555A/en unknown
- 1992-12-16 RO RO94-01055A patent/RO112086B1/ro unknown
- 1992-12-16 AT AT93902088T patent/ATE177645T1/de not_active IP Right Cessation
- 1992-12-16 CZ CZ941458A patent/CZ282826B6/cs unknown
- 1992-12-16 KR KR1019940702140A patent/KR100270726B1/ko not_active IP Right Cessation
- 1992-12-16 HU HU9401831A patent/HUT69682A/hu unknown
- 1992-12-16 CA CA002125856A patent/CA2125856A1/en not_active Abandoned
-
1994
- 1994-05-30 BG BG98804A patent/BG98804A/bg unknown
- 1994-06-17 NO NO942299A patent/NO942299L/no unknown
- 1994-06-17 FI FI942905A patent/FI942905A/fi not_active Application Discontinuation
-
1995
- 1995-06-06 US US08/469,283 patent/US5851992A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ246555A (en) | 1996-03-26 |
| RU94045921A (ru) | 1996-08-27 |
| HUT69682A (en) | 1995-09-28 |
| JP3662580B2 (ja) | 2005-06-22 |
| CZ282826B6 (cs) | 1997-10-15 |
| EP0618806A1 (en) | 1994-10-12 |
| CZ145894A3 (en) | 1994-12-15 |
| KR100270726B1 (ko) | 2000-11-01 |
| FI942905A0 (fi) | 1994-06-17 |
| US5977069A (en) | 1999-11-02 |
| DE69228704T2 (de) | 1999-09-16 |
| EP0618806B1 (en) | 1999-03-17 |
| SK73794A3 (en) | 1995-03-08 |
| RU2098130C1 (ru) | 1997-12-10 |
| DE69228704D1 (de) | 1999-04-22 |
| WO1993012811A1 (en) | 1993-07-08 |
| CA2125856A1 (en) | 1993-07-08 |
| RO112086B1 (ro) | 1997-05-30 |
| DK204791D0 (da) | 1991-12-20 |
| ATE177645T1 (de) | 1999-04-15 |
| AU3344593A (en) | 1993-07-28 |
| FI942905A (fi) | 1994-06-17 |
| HU9401831D0 (en) | 1994-09-28 |
| BG98804A (bg) | 1995-02-28 |
| JPH07502515A (ja) | 1995-03-16 |
| KR940703689A (ko) | 1994-12-12 |
| NO942299L (no) | 1994-06-17 |
| US5851992A (en) | 1998-12-22 |
| AU664416B2 (en) | 1995-11-16 |
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