FI942905A - Stabiloitu kasvuhormonia ja asparagiinia sisältävä farmaseuttinen formulointi - Google Patents
Stabiloitu kasvuhormonia ja asparagiinia sisältävä farmaseuttinen formulointi Download PDFInfo
- Publication number
- FI942905A FI942905A FI942905A FI942905A FI942905A FI 942905 A FI942905 A FI 942905A FI 942905 A FI942905 A FI 942905A FI 942905 A FI942905 A FI 942905A FI 942905 A FI942905 A FI 942905A
- Authority
- FI
- Finland
- Prior art keywords
- growth hormone
- asparagine
- pharmaceutical formulation
- formulation containing
- containing growth
- Prior art date
Links
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 title abstract 2
- 229960001230 asparagine Drugs 0.000 title abstract 2
- 235000009582 asparagine Nutrition 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK912047A DK204791D0 (da) | 1991-12-20 | 1991-12-20 | Hidtil ukendt farmaceutisk praeparat |
| PCT/DK1992/000378 WO1993012811A1 (en) | 1991-12-20 | 1992-12-16 | A stabilized pharmaceutical formulation comprising growth hormone and asparagine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI942905A true FI942905A (fi) | 1994-06-17 |
| FI942905A0 FI942905A0 (fi) | 1994-06-17 |
Family
ID=8109696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942905A FI942905A0 (fi) | 1991-12-20 | 1994-06-17 | Stabiloitu kasvuhormonia ja asparagiinia sisältävä farmaseuttinen formulointi |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5977069A (fi) |
| EP (1) | EP0618806B1 (fi) |
| JP (1) | JP3662580B2 (fi) |
| KR (1) | KR100270726B1 (fi) |
| AT (1) | ATE177645T1 (fi) |
| AU (1) | AU664416B2 (fi) |
| BG (1) | BG98804A (fi) |
| CA (1) | CA2125856A1 (fi) |
| CZ (1) | CZ282826B6 (fi) |
| DE (1) | DE69228704T2 (fi) |
| DK (1) | DK204791D0 (fi) |
| FI (1) | FI942905A0 (fi) |
| HU (1) | HUT69682A (fi) |
| NO (1) | NO942299D0 (fi) |
| NZ (1) | NZ246555A (fi) |
| RO (1) | RO112086B1 (fi) |
| RU (1) | RU2098130C1 (fi) |
| SK (1) | SK73794A3 (fi) |
| WO (1) | WO1993012811A1 (fi) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| US5849704A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5849700A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| US5652216A (en) * | 1994-05-26 | 1997-07-29 | Novo Nordisk A/S | Pharmaceutical preparation |
| US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5654278A (en) * | 1994-10-13 | 1997-08-05 | Novo Nordisk A/S | Composition and method comprising growth hormone and leucine |
| ZA96122B (en) * | 1995-01-13 | 1996-07-24 | Novo Nordisk As | A pharmaceutical formulation |
| US5705482A (en) * | 1995-01-13 | 1998-01-06 | Novo Nordisk A/S | Pharmaceutical formulation |
| WO1996021460A1 (en) * | 1995-01-13 | 1996-07-18 | Novo Nordisk A/S | A stabilized pharmaceutical formulation comprising a growth hormone and x-lys |
| US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
| ZA965367B (en) * | 1995-07-12 | 1997-01-23 | Novo Nordisk As | A pharmaceutical formulation |
| WO1997007794A1 (fr) * | 1995-08-28 | 1997-03-06 | Showa Yakuhin Kako Co., Ltd. | Composition pour anesthesie locale |
| US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
| EP1309312A2 (en) * | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| WO2002092619A2 (en) * | 2001-05-14 | 2002-11-21 | The Gouvernment Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified growth hormone |
| RU2234945C2 (ru) * | 2002-10-15 | 2004-08-27 | Вардосанидзе Ирина Викторовна | Стабилизатор водного раствора и водосодержащего сырья с самопроизвольно изменяющимися окислительно-восстановительными свойствами |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| US20080213377A1 (en) * | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
| US20160015789A1 (en) * | 2014-07-17 | 2016-01-21 | Teva Pharmaceutical Industries, Ltd. | FORMULATIONS OF AN ALBUMIN hGH FUSION PROTEIN |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| EP0303746B2 (en) * | 1987-08-21 | 1998-12-02 | Mallinckrodt Group Inc. | Stabilization of growth promoting hormones |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| US5122512A (en) * | 1988-09-12 | 1992-06-16 | Pitman-Moore, Inc. | Swine growth promoting composition |
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| NZ246556A (en) * | 1991-12-20 | 1996-03-26 | Novo Nordisk As | Pharmaceutical composition of a growth hormone and histidine |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| DK0955062T3 (da) * | 1992-07-31 | 2007-09-17 | Genentech Inc | Vandig formulering indeholdende humant væksthormon |
| US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
-
1991
- 1991-12-20 DK DK912047A patent/DK204791D0/da not_active Application Discontinuation
-
1992
- 1992-01-28 US US07/827,178 patent/US5977069A/en not_active Expired - Fee Related
- 1992-12-16 JP JP51136093A patent/JP3662580B2/ja not_active Expired - Fee Related
- 1992-12-16 KR KR1019940702140A patent/KR100270726B1/ko not_active IP Right Cessation
- 1992-12-16 RU RU9494045921A patent/RU2098130C1/ru active
- 1992-12-16 AT AT93902088T patent/ATE177645T1/de not_active IP Right Cessation
- 1992-12-16 CZ CZ941458A patent/CZ282826B6/cs unknown
- 1992-12-16 RO RO94-01055A patent/RO112086B1/ro unknown
- 1992-12-16 AU AU33445/93A patent/AU664416B2/en not_active Ceased
- 1992-12-16 EP EP93902088A patent/EP0618806B1/en not_active Expired - Lifetime
- 1992-12-16 DE DE69228704T patent/DE69228704T2/de not_active Expired - Fee Related
- 1992-12-16 HU HU9401831A patent/HUT69682A/hu unknown
- 1992-12-16 NZ NZ246555A patent/NZ246555A/en unknown
- 1992-12-16 WO PCT/DK1992/000378 patent/WO1993012811A1/en active IP Right Grant
- 1992-12-16 CA CA002125856A patent/CA2125856A1/en not_active Abandoned
- 1992-12-16 SK SK737-94A patent/SK73794A3/sk unknown
-
1994
- 1994-05-30 BG BG98804A patent/BG98804A/bg unknown
- 1994-06-17 NO NO942299A patent/NO942299D0/no unknown
- 1994-06-17 FI FI942905A patent/FI942905A0/fi not_active Application Discontinuation
-
1995
- 1995-06-06 US US08/469,283 patent/US5851992A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CZ145894A3 (en) | 1994-12-15 |
| JP3662580B2 (ja) | 2005-06-22 |
| RO112086B1 (ro) | 1997-05-30 |
| CA2125856A1 (en) | 1993-07-08 |
| DE69228704T2 (de) | 1999-09-16 |
| US5977069A (en) | 1999-11-02 |
| EP0618806A1 (en) | 1994-10-12 |
| DK204791D0 (da) | 1991-12-20 |
| RU94045921A (ru) | 1996-08-27 |
| US5851992A (en) | 1998-12-22 |
| WO1993012811A1 (en) | 1993-07-08 |
| FI942905A0 (fi) | 1994-06-17 |
| ATE177645T1 (de) | 1999-04-15 |
| BG98804A (bg) | 1995-02-28 |
| HU9401831D0 (en) | 1994-09-28 |
| EP0618806B1 (en) | 1999-03-17 |
| HUT69682A (en) | 1995-09-28 |
| CZ282826B6 (cs) | 1997-10-15 |
| DE69228704D1 (de) | 1999-04-22 |
| NZ246555A (en) | 1996-03-26 |
| KR100270726B1 (ko) | 2000-11-01 |
| KR940703689A (ko) | 1994-12-12 |
| AU3344593A (en) | 1993-07-28 |
| AU664416B2 (en) | 1995-11-16 |
| SK73794A3 (en) | 1995-03-08 |
| NO942299L (no) | 1994-06-17 |
| NO942299D0 (no) | 1994-06-17 |
| RU2098130C1 (ru) | 1997-12-10 |
| JPH07502515A (ja) | 1995-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |