NO934431L - Boven herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnostiske sett for paavisning av bovin herpesvirus type 1 - Google Patents

Boven herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnostiske sett for paavisning av bovin herpesvirus type 1

Info

Publication number
NO934431L
NO934431L NO934431A NO934431A NO934431L NO 934431 L NO934431 L NO 934431L NO 934431 A NO934431 A NO 934431A NO 934431 A NO934431 A NO 934431A NO 934431 L NO934431 L NO 934431L
Authority
NO
Norway
Prior art keywords
herpesvirus type
bovine herpesvirus
well
diagnostic kits
gene
Prior art date
Application number
NO934431A
Other languages
English (en)
Inventor
Franciscus Antonius Rijsewijk
Van Johannes Theodoru Oirschot
Roger Kamiel Maes
Original Assignee
Stichting Centr Diergeneeskund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19859344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO934431(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stichting Centr Diergeneeskund filed Critical Stichting Centr Diergeneeskund
Publication of NO934431L publication Critical patent/NO934431L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/265—Infectious rhinotracheitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/087—Herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16732—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16741—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Delesjonsmutant av bovin herpesvirus type 1 som har en delesjon i glykoprotein-gE-genet. Mutanten kan videre ha en delesjon i tymidin kinasegenet og/eller glykoprotein-gl-genet, eller ha et innskudd av et heterologt gen. Rekombinante nukleinsyrer som omfatter gE-genet eller en del derav. Glykoprotein-gE, peptider basert på dette og komplekser av glykoproteinene gE og gl, samt antistoff • mot disse. Vaksiner og diagnostiske sett omfatter ethvert av disse materialer.
NO934431A 1991-06-07 1993-12-06 Boven herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnostiske sett for paavisning av bovin herpesvirus type 1 NO934431L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9100989A NL9100989A (nl) 1991-06-07 1991-06-07 Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1.
PCT/NL1992/000097 WO1992021751A1 (en) 1991-06-07 1992-06-05 Bovine herpesvirus type 1 deletion mutants, vaccines based thereon, diagnostic kits for detection of bovine herpesvirus type 1

Publications (1)

Publication Number Publication Date
NO934431L true NO934431L (no) 1994-02-07

Family

ID=19859344

Family Applications (2)

Application Number Title Priority Date Filing Date
NO934431A NO934431L (no) 1991-06-07 1993-12-06 Boven herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnostiske sett for paavisning av bovin herpesvirus type 1
NO934431D NO934431D0 (no) 1991-06-07 1993-12-06 Bovin herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnosti ske sett for paavisning av bovin herpesvirus type 1

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO934431D NO934431D0 (no) 1991-06-07 1993-12-06 Bovin herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnosti ske sett for paavisning av bovin herpesvirus type 1

Country Status (20)

Country Link
US (3) US5676951A (no)
EP (1) EP0587805B2 (no)
JP (3) JPH06508032A (no)
KR (1) KR100293761B1 (no)
AT (1) ATE143412T1 (no)
AU (1) AU671802B2 (no)
CA (1) CA2110519C (no)
CZ (1) CZ283283B6 (no)
DE (1) DE69214146T3 (no)
DK (1) DK0587805T4 (no)
ES (1) ES2097340T5 (no)
FI (1) FI110060B (no)
GR (1) GR3022138T3 (no)
HU (1) HU219602B (no)
NL (1) NL9100989A (no)
NO (2) NO934431L (no)
RU (1) RU2170254C2 (no)
SK (1) SK280862B6 (no)
UA (1) UA40571C2 (no)
WO (1) WO1992021751A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783195A (en) * 1991-07-18 1998-07-21 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus S-IBR-052 and uses thereof
US6410033B1 (en) 1987-07-27 2002-06-25 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
FR2693472B1 (fr) * 1992-06-26 1994-12-23 Rhone Merieux Mutants du virus de la rhinotrachéite infectieuse bovine, délétés dans l'un des gènes des glycoprotéines mineures, vaccins préparés à partir de ces souches, méthodes de production et méthodes d'utilisation.
ATE196163T1 (de) * 1990-10-04 2000-09-15 Res Corp Technologies Inc Varicella-zoster virusantigen
NL9100989A (nl) * 1991-06-07 1993-01-04 Stichting Centr Diergeneeskund Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1.
CA2113641A1 (en) * 1991-07-18 1993-02-04 Mark D. Cochran Recombinant infectious bovine rhinotracheitis virus
DE4141400A1 (de) * 1991-12-16 1993-06-17 Bayer Ag Impfstoffe auf basis geaenderter boviner herpesviren typ 1
AU676471B2 (en) * 1992-03-20 1997-03-13 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Fungus-responsive chimaeric gene
WO1994024296A2 (en) * 1993-04-19 1994-10-27 University Of Saskatchewan Recombinant bovine herpesvirus type 1 vaccines
CA2136381A1 (en) * 1993-11-23 1995-05-24 Gunther Keil Vector vaccines of bovine herpesvirus 1
ES2074965B1 (es) * 1994-01-31 1996-05-01 Hipra Lab Sa Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.
ES2088371B1 (es) * 1995-02-01 1997-04-16 Hipra Lab Sa Procedimiento para la produccion en forma recombinante de antigenos de la glicoproteina ge de herpesvirus bovino tipo 1 y su uso en la diferenciacion serologica entre animales infectados y animales vacunados.
US6284251B1 (en) * 1996-02-26 2001-09-04 Kansas State University Research Foundation BHV-1 gene-deleted virus vaccine
US6221360B1 (en) * 1996-02-26 2001-04-24 Kansas State University Research Foundation Infectious bovine rhinotracheitis vaccines and methods
EP2365082A1 (en) 2000-06-27 2011-09-14 Pfizer Animal Health S.A. BVDV virus-like particles
US6935866B2 (en) * 2002-04-02 2005-08-30 Adc Telecommunications, Inc. Card edge coaxial connector
EP1594537B1 (en) 2003-02-19 2012-10-24 Merial Vaccination or immunization using a prime-boost regimen against brsv, bhv-1, bvdv, bpi-3
US8383115B2 (en) * 2007-07-19 2013-02-26 Azad Kumar Kaushik Engineered scFv against bovine herpes virus type I
EP2108375A1 (de) * 2008-04-10 2009-10-14 Riemser Arzneimittel AG Lebendimpfstoffzusammensetzung
CN102649948B (zh) * 2011-02-23 2016-05-25 华中农业大学 牛传染性鼻气管炎ΔTK/ΔgE基因缺失标志活疫苗及制备方法
US8877211B2 (en) 2011-06-27 2014-11-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Bovine herpes virus vaccine with multiple mutations
AU2012278930B2 (en) * 2011-07-05 2016-01-14 Meat & Livestock Australia Limited Recombinant low virulence bovine herpesvirus 1 (BoHV-1) vaccine vectors
CN103923884B (zh) * 2014-02-21 2017-03-29 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
EP2942628A1 (en) 2014-05-08 2015-11-11 In3diagnostic S.r.l. Kit and in vitro method for identifying Bovine Herpes Virus 1 infections
ES2847203T3 (es) 2014-08-01 2021-08-02 The Board Of Supervisors Of Louisiana State Univ And Agricultural And Mechanical College Detección y tratamiento de herpesvirus bovino

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703011A (en) * 1985-11-12 1987-10-27 Novagene, Inc. Thymidine kinase deletion mutants of bovine herpesvirus-1
US5593873A (en) * 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
US4992051A (en) * 1987-11-03 1991-02-12 Novagene, Inc. Infectious bovine rhinotracheitis virus mutants, methods for the production of same and methods for the use of same
EP0326127A3 (en) * 1988-01-26 1990-03-28 Novagene, Inc. Infectious bovine rhinotracheitis virus insertion mutants, vaccins containing same, and methods for the production and use of same
WO1989010965A2 (en) * 1988-05-03 1989-11-16 The Upjohn Company Glycoprotein h of herpes viruses
NL9100989A (nl) * 1991-06-07 1993-01-04 Stichting Centr Diergeneeskund Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1.
DE4141400A1 (de) * 1991-12-16 1993-06-17 Bayer Ag Impfstoffe auf basis geaenderter boviner herpesviren typ 1

Also Published As

Publication number Publication date
AU2275092A (en) 1993-01-08
JP2010104367A (ja) 2010-05-13
CA2110519C (en) 2001-07-17
FI935459A0 (fi) 1993-12-07
JP4486055B2 (ja) 2010-06-23
ES2097340T3 (es) 1997-04-01
GR3022138T3 (en) 1997-03-31
SK137593A3 (en) 1994-09-07
JP2006296426A (ja) 2006-11-02
ES2097340T5 (es) 2005-04-16
UA40571C2 (uk) 2001-08-15
DE69214146T2 (de) 1997-02-13
FI110060B (fi) 2002-11-29
DK0587805T3 (no) 1997-03-17
AU671802B2 (en) 1996-09-12
HU9303470D0 (en) 1994-04-28
NL9100989A (nl) 1993-01-04
SK280862B6 (sk) 2000-08-14
DE69214146T3 (de) 2005-05-04
FI935459A (fi) 1994-02-07
CA2110519A1 (en) 1992-12-10
JPH06508032A (ja) 1994-09-14
US5789177A (en) 1998-08-04
HU219602B (hu) 2001-05-28
WO1992021751A1 (en) 1992-12-10
ATE143412T1 (de) 1996-10-15
DE69214146D1 (de) 1996-10-31
HUT69602A (en) 1995-09-28
NO934431D0 (no) 1993-12-06
DK0587805T4 (da) 2004-12-20
RU2170254C2 (ru) 2001-07-10
EP0587805A1 (en) 1994-03-23
CZ264693A3 (en) 1994-05-18
EP0587805B2 (en) 2004-09-22
EP0587805B1 (en) 1996-09-25
US5676951A (en) 1997-10-14
KR100293761B1 (ko) 2001-10-22
US6403097B1 (en) 2002-06-11
CZ283283B6 (cs) 1998-02-18

Similar Documents

Publication Publication Date Title
NO934431L (no) Boven herpesvirus type 1 delesjonmutanter, vaksiner basert paa disse, samt diagnostiske sett for paavisning av bovin herpesvirus type 1
DE69430071D1 (de) Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem
ES2177536T3 (es) G-csf exento de metionina, procedente de procariotas.
AU3867789A (en) Recombinant mycobacterial expression vehicles and uses therefor
AU1227295A (en) Melanoma associated antigenic polypeptide, epitopes thereof and vaccines against melanoma
CA2113712A1 (en) Papilloma virus vaccine
DE69435224D1 (de) Rekombinante Alphavirus-Vektoren
TR199501134A2 (tr) Memeli ve viral proteinleri asiri ifade edilmesi.
EP1164195A3 (en) Adeno-associated virus with inverted terminal repeat sequences as promoter
ES555124A0 (es) Procedimiento de preparar particulas que contienen secuencias de aminoacidos y que tienen propiedades inmunogenas
WO1999009186A3 (fr) Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose
PT988391E (pt) Vectores adenovirais recombinantes compreendendo uma sequencia de splicing
WO1995032731A3 (en) Immunogenic pharmaceuticals
AU3594089A (en) Poultry mycoplasma antigens and recombinant vectors containing the gene as well as diagnostics and vaccines utilizing the same
ES2194012T3 (es) Epitopo p1a1 y p1a2 de la gpiii a de plaquetas, su preparacion y uso.
AU6889194A (en) Recombinant adenovirus vaccines
EP0293827A3 (en) Assay for leishmaniasis
EP0385391A3 (de) Expressionsvektoren zur Synthese von Proteinen in der Spalthefe Schizosaccharomyces pombe
MY107451A (en) Cloning and expression of a rhoptry associated protein of p.falciparum
Schindler Weight functions for deep cracks and high stress gradients
IE881016L (en) Stable creatine amidinohydrolase mutants
MX9204969A (es) Mutantes del virus de herpes bovino tipo 1 y vacunas a base de los mismos.
Tischendorf et al. Oz-Markers: Their Occurrence in Subtypes of Human Lambda Immunoglobulin Chains
ZA926193B (en) Bovine herpesvirus type 1 deletion mutants, vaccines based thereon, diagnostic kits for detection of bovine herpesvirus type 1.
ATE88640T1 (de) Verwendung des tumor-nekrose-faktors als adjuvans der immunantwort.